Ekofuril capsules 200mg, No. 16

Acute and chronic diarrhea of ??infectious origin (without signs of helminthic invasion).
Chronic colitis and enterocolitis.

Take internally.
Adults and children over 7 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 4 times a day (800 mg / day).
Children 3-7 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 3 times a day (600 mg / day).
The duration of nifuroxazide therapy is no more than 7 days.

for a dosage of 200 mg:
active substance: nifuroxazide 200.0 mg;
auxiliary substances: lactulose - 300.0 mg, microcrystalline cellulose - 58.0 mg, potato starch - 18.0 mg, magnesium stearate - 6.0 mg, sucrose before obtaining the mass of the contents of the capsule. 630.0 mg.
hard gelatin capsules No. 00 [gelatin (up to 100%), water (14-15%), lid: crimson dye [Ponso 4R] (0.079801%), patented blue dye (0.00165%), sunset dye ( 0.093301%), titanium dioxide (0.813158%),
body: quinoline yellow dye (0.583356%), sunset dye (0.002565%), titanium dioxide (0.974035%)].

Hypersensitivity to nifuroxazide, other components of the drug, other derivatives of 5-nitrofuran. Sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Children's age up to 3 years (for this lekform).

Trade name of the drug

EcofurilЃ

International non-proprietary name

nifuroxazide

Dosage form

capsules

Composition for one capsule

for a dosage of 100 mg:
active substance: nifuroxazide 100.0 mg;
auxiliary substances: lactulose - 300.0 mg, microcrystalline cellulose - 23.0 mg, potato starch - 9.0 mg, magnesium stearate - 4.0 mg, sucrose before obtaining the mass of the contents of the capsule is 460.0 mg.
hard gelatin capsules No. 0 [gelatin (up to 100%, water (14-15%), quinoline yellow dye (0.5834%), sunset dye (0.0026%), titanium dioxide (0.9740%)];

for a dosage of 200 mg:
active substance: nifuroxazide 200.0 mg;
auxiliary substances: lactulose - 300.0 mg, microcrystalline cellulose - 58.0 mg, potato starch - 18.0 mg, magnesium stearate - 6.0 mg, sucrose before obtaining the mass of the contents of the capsule. 630.0 mg.
hard gelatin capsules No. 00 [gelatin (up to 100%), water (14-15%), lid: crimson dye [Ponso 4R] (0.079801%), patented blue dye (0.00165%), sunset dye ( 0.093301%), titanium dioxide (0.813158%),
body: quinoline yellow dye (0.583356%), sunset dye (0.002565%), titanium dioxide (0.974035%)].

Description
Yellow hard gelatin capsules No. 0 (for a dosage of 100 mg) and capsules No. 00 with a yellow body and an orange cap (for a dosage of 200 mg). The contents of the capsules are yellow granular powder with white splashes.

Pharmacotherapeutic group

antimicrobial agent - nitrofuran

Pharmacological properties

Broad-spectrum antimicrobial agent - 5-nitrofuran derivative. Used to treat infections of the gastrointestinal tract. Nifuroxazide blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and other biochemical reactions in the bacterial cell. Destroys the membranes of sensitive bacteria, reduces the production of toxins by microorganisms. It activates the immune system, increases the activity of phagocytes and the titer of complement. Effective against gram-positive microorganisms:
Staphylococcus spp .;
Streptococcus spp.

and gram-negative microorganisms:
Salmonella spp .;
Klebsiella spp .;
Enterobacter spp .;
Escherichia coli;
Shigella spp .;
Proteus spp .;
Haemophilus influenzae;
Campilobacter spp .;
Edwarsiella spp .;
Citrobacter spp .;
Vibrio cholerae;
Yersinia enterocolitica.

Nifuroxazide does not affect the state of the normal microflora of the human intestine. In case of acute bacterial diarrhea, it restores intestinal eubiosis. When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics
After oral administration, nifuroxazide is practically not absorbed in the gastrointestinal tract and has no systemic effect. It exhibits antibacterial activity against susceptible bacterial species only in the intestinal lumen. It is excreted unchanged by the intestines. The rate of elimination depends on the dose of the drug and the motility of the gastrointestinal tract.

Indications for use

Acute and chronic diarrhea of ??infectious origin (without signs of helminthic invasion).
Chronic colitis and enterocolitis.

Contraindications

Hypersensitivity to nifuroxazide, other components of the drug, other derivatives of 5-nitrofuran. Sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Children's age up to 3 years (for this lekform).

Application during pregnancy and during breastfeeding.

There is no evidence of adverse effects on the fetus during pregnancy. If necessary, with caution, the drug can be prescribed to pregnant women and women who are breastfeeding.

Method of administration and dosage

Take internally.
Adults and children over 7 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 4 times a day (800 mg / day).
Children 3-7 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 3 times a day (600 mg / day).
The duration of nifuroxazide therapy is no more than 7 days.

Overdose

Specific symptoms of overdose have not been described. Standard emergency measures are recommended.

Side effect

Allergic reactions.

Interaction with other medicinal products
Data on the interaction of nifuroxazide with other medicinal products have not been published.

special instructions

When treating diarrhea concomitantly with nifuroxazide therapy, rehydration therapy (oral or intravenous) should be carried out in accordance with the patient's condition and the duration of the diarrhea. During therapy with nifuroxazide, alcohol is not allowed.

Influence on the ability to drive vehicles and perform work requiring increased concentration of attention and speed of psychomotor reactions.
The drug does not adversely affect the ability to drive vehicles and / or other mechanisms.

Release form

Capsules 100 mg and 200 mg. 10 capsules (with a dosage of 100 mg) or 5, 7, 8 capsules (with a dosage of 200 mg) are placed in a blister made of polyvinyl chloride film and lacquered aluminum foil. 30 capsules (with a dosage of 100 mg) or 16, 28 or 30 capsules (with a dosage of 200 mg) in a plastic bottle with a screw cap or a polymer jar with a screw cap. 3 blister packs each (for a dosage of 100 mg) or 2 blister packs of 8 capsules each, 4 blister packs of 7 capsules or 6 blister packs of 5 capsules (for a dosage of 200 mg) or 1 bottle or 1 can together with the instructions for use are placed in a cardboard box.

Storage conditions

In a place protected from moisture and light, at a temperature not exceeding 25 ? C. Keep out of the reach of children.

Shelf life :

5 years. Do not use after the expiration date.

Vacation conditions

Without recipe