Dyatsereyn | Diaflex Rompharm capsules 50 mg 30 pcs.

Release form

Capsules.



packaging 30 pcs

Pharmacological action

Diaflex - drug, used in inflammatory and inflammatory-dystrophic diseases of the musculoskeletal system. Diacerein is an anthraquinoline derivative, a diacetylated rhein derivative. Metabolizing to an active metabolite, rhein, inhibits the activity of interleukin-1, which plays an important role in the development of inflammation and cartilage degradation in osteoarthritis. It inhibits the action of other cytokines (including interleukin-6, TNF alpha). The action develops in 2-4 weeks.

Indications

Primary and secondary osteoarthritis.

Contraindications

Hypersensitivity (including to anthraquinone drugs (laxatives)), pregnancy, lactation, age under 18 years. Carefully. CRF, irritation of the lower intestines.

Use during pregnancy and lactation

Contraindicated.

Composition

1 capsule contains diacerein 50 mg.

Dosage and administration of

Diaflex is taken orally, after eating, it is necessary to swallow whole, without chewing, with water, 50 mg 2 times a day (morning and evening).

Continuously for a long time or in courses (at least 4 months).

Diacerein during the first 2 weeks can cause an acceleration of transit in the intestine, so it is recommended to start treatment with one capsule daily in the evening with food for 4 weeks. Then the dose is increased to 100 mg / day.

Side effects of the

Digestive system: diarrhea, nausea, vomiting, abdominal pain, hepatitis.

Allergic reactions: urticaria, fever, bronchospasm, angioedema, anaphylactic shock.

Other: malaise, intense staining of urine (depending on pH) from yellow to brown (has no clinical significance).

Drug Interaction

Antacids reduce the absorption of the drug. At simultaneous reception with the drugs influencing intestinal microflora (including with antibiotics), with substances, altering the quality of the contents of the intestine and the rate of its emptying (fiber), increases the frequency of side effects from the intestine.

drugs containing aluminum hydroxide and / or magnesium hydroxide reduce the bioavailability of diacerein.

Concomitant use with laxatives is not recommended.

Overdose

Symptoms: diarrhea, weakness.

Treatment: symptomatic. With severe diarrhea, control of the plasma electrolyte composition is required.

Storage conditions

The drug should be stored in a dark place, out of the reach of children, at a temperature not exceeding 25 РC.

Expiration

Expiration is 3 years.

Deystvuyuschee substances

Dyatsereyn

Terms of delivery from pharmacies

Prescription

Dosage form

dosage form

capsules

K.O.Rompharm Company S.R.L., Romania