Dironet 1000 tablets for large breed dogs 6 tablets

DESCRIPTION

Dironet - tablets for the treatment and prevention of nematodes and cestodoses in dogs of large breeds. Tablets from yellow to gray, flat, with a line on one side, on the other - a logo (a cross in the center of the shield).

COMPOSITION

Dironet tablets contain 450 mg of pyrantel pamoate, 150 mg of praziquantel and 18 mg of ivermectin O as active ingredients. The preparation contains lactose and potato starch as auxiliary substances.

PHARMACOLOGICAL PROPERTIES

Dironet has a wide spectrum of anthelmintic action at all stages of the development of round and tape helminths, including Toxocara canis, Toxocara mystax, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma spp., Trichuris vulpis, Echinococloccus granulosus Dipylumus, Echinococloccus granulosus Dipylum caninum, Multiceps multiceps, Taenia spp., parasitizing in dogs and cats. Ivermectin of the drug has a detrimental effect on the larvae (microfilariae) of helminths Dirofilaria immitis and Dirofilaria repens in dogs by changing the current of chlorine ions through the membranes of the parasite's neuromuscular cells. The main targets are glutamate-sensitive chlorine channels as well as GABA receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite. The maximum concentration of ivermectin in blood plasma is observed 9 hours after oral administration of the drug. The mechanism of action of pyrantel pamoate is to block neuromuscular transmission, disrupt the permeability of cell membranes and inhibition of cholinesterase, which also leads to paralysis and death of the helminth. The maximum concentration of pyrantel pamoate in blood plasma is observed after 2? 4 hours. Praziquantel, which is part of the suspension, increases the permeability of the cell membranes of cestodes for calcium ions, causing spastic contraction of the parasite's muscles, which turns into paralysis. All active components of the drug are excreted from the body with waste products during the day. Dironet, according to the degree of impact on the body of warm-blooded animals, belongs to low-hazard substances (IV hazard class according to GOST dated 15.06.

DOSAGE AND APPLICATION

Prevention and treatment of intestinal nematodes and cestodoses in dogs and cats. Prevention of canine dirofilariasis.

In case of nematodes and cestodoses of the gastrointestinal tract, Dironet is used for therapeutic and prophylactic purposes individually orally once in the morning feeding in the following doses: pyrantel pamoat -15 mg / kg, praziquantel -5 mg / kg, ivermectin -0.006 mg / kg, at the rate of 1 tablet: Dironet 1000 per 30 kg weight of large breed dogs.

To reduce the number of microfilariae circulating in the blood of animals infested with D. immitis or D. repens, the drug is prescribed in a therapeutic dose once, once a month.

In order to prevent dirofilariasis in a region unfavorable for the disease, Dironet is used in the spring-summer-autumn period: once before the beginning of summer mosquitoes (March-April), then monthly from April to October, and the last time in the season 1 month after the end of summer mosquitoes (October November).

SIDE EFFECTS

As a rule, there are no side effects and complications when using the drug Dironet tablets in accordance with the instructions.

With increased individual sensitivity of the animal to the active components of the drug and the appearance of allergic reactions, its use is discontinued and antihistamines and symptomatic therapy are prescribed to the animal.

In case of an overdose of the drug, the animal may experience a depression, refusal to feed, excessive salivation, and gastrointestinal upset. In these cases, enterosorbents and symptomatic therapy are used.

CONTRAINDICATIONS

Individual hypersensitivity of the animal to the constituent components of the drug. Do not use the drug: for puppies and kittens under 3 weeks of age; pregnant and lactating animals.

For puppies of the bobtail, collie and sheltie breeds, due to the increased sensitivity of these breeds to macrocyclic lactones, the drug should be used under the supervision of the attending veterinarian.

SPECIAL INSTRUCTIONS

When using Dironet, personal hygiene and instructions for working with medicines for animals are strictly observed.

SHELF LIFE AND STORAGE

The drug should be stored in the manufacturer's sealed packaging, separately from food and feed, protected from light and moisture, out of the reach of children, at temperatures from 0 В° to 25 В° C. Shelf life is 2 years.

Unused medicinal product is disposed of in accordance with legal requirements.

PACKAGING

Available in tablets, packaged in blisters of 6 tablets.

Specifications

Bonus points

0

KolVUP

one hundred

Manufacturer

Agrovetzashita

Temperature regime

from 0 to +25

Teaser

anthelmintic drug for dogs