Dienomast (20 doses) 100ml

DESCRIPTION

Dienomast is used to treat mastitis in lactating cows.

COMPOSITION

1.0 ml contains 8.75 mg of dioxidine and 17.5 mg of gentamicin sulfate as active ingredients, as well as auxiliary substances: 43.75 mg of beeswax or beeswax and vaseline oil - up to 1 ml.

PHARMACOLOGICAL PROPERTIES

Dienomast belongs to the combined antibacterial drugs for intracisternal administration.

Dioxidine (hydroxymethylquinoxalindioxide) - 2,3-di- (hydroxymethyl) quinoxaline-1,4-dioxide is an antibacterial agent from the quinoxaline group, is active against gram-negative and gram-positive microorganisms, has a bactericidal effect. The action of dioxidine is due to a violation of the biosynthesis of DNA of a microbial cell.

Gentamicin sulfate belongs to antibacterial drugs from the group of aminoglycoside antibiotics, is a mixture of several antibiotics produced by Micromonospora purpurea, has a wide spectrum of antimicrobial action, is active against gram-positive and some gram-negative microorganisms, including Pseudomonas aeruginosa and Escherichia coli, Proteus, Salmonocella affects strains of staphylococci that are resistant to penicillin; does not act on anaerobic bacteria, fungi, viruses and protozoa. The mechanism of bactericidal action is due to the irreversible binding of the antibiotic to specific receptors of bacterial ribosomes and a violation of the synthesis of proteins of cytoplasmic membranes, which leads to the death of bacterial cells.

With intracisternal administration of the drug, gentamicin and dioxidin are poorly absorbed and have an antibacterial effect mainly in the parenchyma of the mammary gland. Gentamicin and dioxidin are excreted from the body of the animal in unchanged form, mainly with milk and to a small extent with urine.

Dienomast according to the degree of impact on the body according to GOST 12.1.007-76 refers to low-hazard substances (hazard class 4). When administered intracisternally into the mammary gland of clinically healthy lactating cows, the drug causes a slight, rapidly passing irritation of the udder tissues.

DOSAGE AND APPLICATION

Dienomast is administered intracisternally: for subclinical, serous and catarrhal mastitis, 5 ml once a day for 3-4 days; with purulent-catarrhal mastitis - the first injection of 10 ml, then 5 ml at intervals of 24 hours for 5-6 days.

Before the introduction of the drug from the diseased quarter of the udder, the secret is milked out, and the nipple is disinfected with 70% ethyl alcohol.

Before use, Dienomast is heated to 36-39 В° C and shaken. The drug is collected from the vial with a sterile syringe and injected into the nipple of the affected quarter of the udder using a catheter. When using a syringe-dispenser, its cannula is tightly pressed against the opening of the nipple canal and the drug is injected. After the introduction, a light massage of the udder is carried out from the bottom up.

Before the introduction of the second dose of the drug remaining in the syringe-dispenser, the cannula of the syringe-dispenser is treated with 70% ethyl alcohol.

SPECIAL INSTRUCTIONS

Overdose symptoms were not revealed in animals.

Skipping the next dose of the drug should be avoided, as this can lead to a decrease in its therapeutic efficacy. If one dose is missed, the use of the drug is resumed in the same dosage and according to the same scheme.

Slaughter of cows for meat is allowed no earlier than 7 days after the last injection of the drug.

The meat of animals that were forcedly killed before the expiration of the specified period can be used as feed for fur animals.

For food purposes, milk is used no earlier than 7 days after the last injection of Dienomast, provided that the signs of mastitis, confirmed by mastitis tests, disappear completely.

During treatment and within 7 days after the last use of the drug, milk from the affected quarters is disposed of, and from the rest, it is used after boiling into animal feed.

CONTRAINDICATIONS

A contraindication to the use of Dienomast is the increased individual sensitivity of the animal to the components of the drug, including a history.

It is forbidden to use Dienomast simultaneously with other oto- and nephrotoxic drugs (streptomycin, kanamycin, neomycin, polymyxin B, diuretic drugs).

SIDE EFFECTS

When using Dienomast in accordance with this instruction, side effects and complications in cows, as a rule, are not observed. In the event of allergic reactions, the use of the drug is discontinued and antihistamines and symptomatic agents are prescribed to the animal.

SHELF LIFE AND STORAGE

Dienomast is stored in a closed manufacturer's packaging in a dry, dark place, separate from food and feed, at a temperature of 5 В° C to 20 В° C. The shelf life of the medicinal product, subject to storage conditions, is 2 years from the date of manufacture.

PACKAGING

Glass bottle 100 ml.

Specifications

KolVUP

80

Manufacturer

AgroFarm

Temperature regime

from +5 to +20

Teaser

for the treatment of cow mastitis caused by staphylococci, streptococci, E. coli and other microorganisms, including antibiotic-resistant