Dibikor tablets 250mg, No. 60

• type 2 diabetes mellitus, incl. with moderate hypercholesterolemia;

• type 1 diabetes mellitus;

• cardiovascular insufficiency of various etiologies;

• intoxication caused by cardiac glycosides;

• as a hepatoprotector in patients taking antifungal drugs.

The drug is taken orally, 20 minutes before meals.

With type 2 diabetes mellitus, incl. with moderate hypercholesterolemia, appoint 500 mg 2 times / day as monotherapy or in combination with other hypoglycemic agents for oral administration; the duration of the course - as recommended by the doctor.

In type 1 diabetes mellitus, it is recommended to take 500 mg 2 times / day in combination with insulin therapy for 3-6 months.

In case of cardiovascular insufficiency , 250-500 mg is prescribed 2 times / day; the course of treatment is 30 days. The dose can be increased to 2-3 g / day or reduced to 125 mg per dose.

In case of intoxication with cardiac glycosides, at least 750 mg / day is prescribed.

As a hepatoprotector, it is recommended to take 500 mg 2 times / day during the entire course of the use of antifungal drugs.

Active substance: taurine

• age up to 18 years (efficacy and safety have not been established);

• hypersensitivity to the drug.

Clinical and pharmacological group: A drug that improves metabolism and energy supply of tissues

Pharmaco-therapeutic group: Metabolic agent

pharmachologic effect

Taurine is a natural metabolic product of sulfur-containing amino acids: cysteine, cysteamine, methionine. Taurine has osmoregulatory and membrane-protective properties, has a positive effect on the phospholipid composition of cell membranes, and normalizes the exchange of calcium and potassium ions in cells. Taurine has the properties of an inhibitory neurotransmitter, it has an anti-stress effect, can regulate the release of GABA, adrenaline, prolactin and other hormones, as well as regulate responses to them. Taking part in the synthesis of proteins of the respiratory chain in mitochondria, taurine regulates oxidative processes and exhibits antioxidant properties; affects enzymes, such as cytochromes, which are responsible for the metabolism of various xenobiotics.

DibikorЃ improves metabolic processes in the heart, liver and other organs and tissues. In chronic diffuse liver diseases, DibikorЃ increases blood flow and reduces the severity of cytolysis. Treatment with DibikorЃ in cardiovascular insufficiency leads to a decrease in stagnation in the pulmonary and large circulatory systems: intracardiac diastolic pressure decreases, myocardial contractility increases (maximum rate of contraction and relaxation, contractility and relaxation indices). The drug moderately lowers blood pressure in patients with arterial hypertension and practically does not affect its level in patients with cardiovascular insufficiency with low blood pressure. DibicorЃ reduces side effects arising from an overdose of cardiac glycosides and slow calcium channel blockers,reduces the hepatotoxicity of antifungal drugs. Increases performance during heavy physical exertion.

In diabetes mellitus, approximately 2 weeks after the start of taking DibicorЃ, the concentration of glucose in the blood decreases. There was also a significant decrease in the concentration of triglycerides, to a lesser extent - in the concentration of cholesterol, a decrease in atherogenic plasma lipids. With prolonged use of the drug (about 6 months), an improvement in the microcirculatory blood flow of the eye was noted.

Pharmacokinetics

After a single dose of the drug in a dose of 500 mg, taurine is determined in the blood after 15-20 minutes, reaching Cmax in 1.5-2 hours.

Completely excreted in a day.

Indications

• type 2 diabetes mellitus, incl. with moderate hypercholesterolemia;

• type 1 diabetes mellitus;

• cardiovascular insufficiency of various etiologies;

• intoxication caused by cardiac glycosides;

• as a hepatoprotector in patients taking antifungal drugs.

Dosage regimen

The drug is taken orally, 20 minutes before meals.

With type 2 diabetes mellitus, incl. with moderate hypercholesterolemia, appoint 500 mg 2 times / day as monotherapy or in combination with other hypoglycemic agents for oral administration; the duration of the course - as recommended by the doctor.

In type 1 diabetes mellitus, it is recommended to take 500 mg 2 times / day in combination with insulin therapy for 3-6 months.

In case of cardiovascular insufficiency , 250-500 mg is prescribed 2 times / day; the course of treatment is 30 days. The dose can be increased to 2-3 g / day or reduced to 125 mg per dose.

In case of intoxication with cardiac glycosides, at least 750 mg / day is prescribed.

As a hepatoprotector, it is recommended to take 500 mg 2 times / day during the entire course of the use of antifungal drugs.

Side effect

Allergic reactions to the components of the drug are possible .

If the side effects are aggravated or any other side effects are noted that are not indicated in the instructions, the patient must inform the doctor about it.

Contraindications for use

• age up to 18 years (efficacy and safety have not been established);

• hypersensitivity to the drug.

Application during pregnancy and lactation

The use of the drug during pregnancy and during breastfeeding is not recommended due to the lack of clinical experience in this category of patients.

Application in children

Contraindicated under the age of 18 (efficacy and safety have not been established).

special instructions

While taking DibicorЃ, the dose of cardiac glycosides should be reduced sometimes by 2 times, depending on the sensitivity of patients to cardiac glycosides. The same rule applies to slow calcium channel blockers.

In the absence of a decrease or in case of aggravation of the symptoms of the disease, the patient should consult a doctor.

Do not exceed the maximum periods and recommended doses of the drug without consulting your doctor.

Influence on the ability to drive vehicles and use mechanisms

The drug does not affect the performance of potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions (including driving vehicles, working with moving mechanisms, the work of a dispatcher, an operator).

Overdose

There are no data on overdose.

Drug interactions

DibikorЃ can be used with other drugs.

The drug enhances the inotropic effect of cardiac glycosides.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ? C.

Shelf life

Shelf life is 3 years. Do not use after the expiration date printed on the package.

Terms of sale

The drug is dispensed without a prescription.