Diazolin tablets 50mg, No. 10

Prevention and treatment of seasonal and allergic rhinitis, hay fever, urticaria, Quincke's edema, allergic dermatoses accompanied by itching (eczema, neurodermatitis, etc.), allergic conjunctivitis, skin reaction after an insect bite.

Dragee should be taken orally, without chewing, during or immediately after a meal.

Adults and children over 10 years old - 100-300 mg / day. The daily dose for children aged 5-10 years is 100-200 mg; 2-5 years old - 50-150 mg; up to 2 years - 50-100 mg. Adults and children from 12 years old are prescribed 100 mg 1-3 times a day.

Higher doses for adults: single - 300 mg, daily - 600 mg. The duration of the course of treatment is determined by the nature of the disease and the achieved therapeutic effect.

mebhydrolin

Hypersensitivity, prostatic hyperplasia, angle-closure glaucoma, gastric ulcer and duodenal ulcer, other inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, cardiac arrhythmias (with vagolytic action, it can improve atrioventricular conduction and promote the development of supraventricular arrhythmias) age up to 12 years (for this dosage form).

pharmachologic effect

A blocker of histamine H1 receptors, a derivative of ethylenediamine. It has antiallergic, antipruritic, antiexudative and mild sedative effect. Possesses m-anticholinergic properties.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability is 40-60%. Practically does not penetrate the BBB. Metabolized in the liver by methylation. Induction of microsomal liver enzymes. It is excreted by the kidneys.

Indications:

Prevention and treatment of seasonal and allergic rhinitis, hay fever, urticaria, Quincke's edema, allergic dermatoses accompanied by itching (eczema, neurodermatitis, etc.), allergic conjunctivitis, skin reaction after an insect bite.

Contraindications:

Hypersensitivity, prostatic hyperplasia, angle-closure glaucoma, gastric ulcer and duodenal ulcer, other inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, cardiac arrhythmias (possessing vagolytic action, can improve atrioventricular conductivity) , children under 12 years of age (for this dosage form).

Carefully:

Use with caution in patients with hepatic and renal insufficiency (dose adjustment and intervals between doses may be required). Pregnancy and lactation:

It is not recommended to use the drug during pregnancy. During the period of breastfeeding, you should stop taking the drug.

Method of administration and dosage:

Dragee should be taken orally, without chewing, during or immediately after a meal.

Adults and children over 10 years old - 100-300 mg / day. The daily dose for children aged 5-10 years is 100-200 mg; 2-5 years old - 50-150 mg; up to 2 years - 50-100 mg. Adults and children from 12 years old are prescribed 100 mg 1-3 times a day.

Higher doses for adults: single - 300 mg, daily - 600 mg. The duration of the course of treatment is determined by the nature of the disease and the achieved therapeutic effect.

Side effects:

From the gastrointestinal tract: it has an irritating effect on the gastrointestinal mucosa, manifested by dyspeptic symptoms (heartburn, nausea, pain in the epigastric region, etc.).

From the side of the nervous system: dizziness, paresthesia, tremor, increased fatigue, drowsiness, anxiety (at night), slowing down the reaction rate.

Others: dry mouth, urinary retention, allergic reactions, very rarely - granulocytopenia and agranulocytosis.

Children have paradoxical reactions: hyperexcitability, irritability, tremors, sleep disturbances.

Interaction:

Enhances the effect of ethanol, sedatives.

Special instructions:

Ineffective for bronchial asthma and anaphylactic shock.

In children aged 2 to 12 years, it is recommended to use 0.05 mg pills.

Influence on the ability to drive vehicles and mechanisms:

During the period of treatment, it is necessary to refrain from driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.