Diara chewable tablets 2mg, No. 12

• Symptomatic treatment of acute and chronic diarrhea of ??various origins (allergic, emotional, drug, radiation); with a change in the diet and the qualitative composition of food, with metabolic and absorption disorders;

• As an adjuvant for infectious diarrhea.

• Stool regulation in patients with ileostomy.

Inside, chewing with water.

For adults with acute and chronic diarrhea, an initial dose of 2 tablets (4 mg) is prescribed; then 1 tablet (2 mg) after each act of defecation (in the case of loose stools); the maximum daily dose is 8 tablets (16 mg).

Children over 6 years of age with acute diarrhea are prescribed 1 tablet (2 mg) in the initial dose, then 1 tablet after each act of defecation (in the case of loose stools); the maximum daily dose is 3 tablets (6 mg).

If stool normalizes or if there is no stool for more than 12 hours, treatment with Diara should be discontinued.

1 chewable tablet contains:

Active ingredient: loperamide hydrochloride - 2.0 mg;

Excipients: polymethylsiloxane, potato starch, lactose (milk sugar), sucrose (sugar) microcrystalline cellulose, colloidal silicon dioxide (aerosil), aspartame, povidone (Kollidon 90), xylitol (Xylitab 300), lactitol, Mentoldon SR stearate, anise oil.

• Hypersensitivity to the drug,

• diverticulosis,

• intestinal obstruction,

• ulcerative colitis in the acute stage,

• diarrhea against the background of acute pseudomembranous enterocolitis, in the form of monotherapy for dysentery and other infections of the gastrointestinal tract (GIT);

• pregnancy (I trimester),

• lactation period,

• children under 6 years old.

With care: liver failure.

Trade name of the drug: DiaraЃ

Dosage form:

Chewable tablets

Composition:

1 chewable tablet contains:

Active ingredient: loperamide hydrochloride 2.0 mg;

Excipients : polymethylsiloxane, potato starch, lactose (milk sugar), sucrose (sugar) microcrystalline cellulose, colloidal silicon dioxide (Aerosil), aspartame, povidone (Kollidon 90), xylitol (Xylitab 300), lactitol, Mentoldon, Magnetide stearate, anise oil.

Description: Tablets of white or white color with a yellowish sheen, flat-cylindrical shape with a risk, with the smell of anise. Light 'marbling' is allowed.

Pharmacotherapeutic group : antidiarrheal agent

ATX CODE: [A07DA03]

Pharmacological properties

Pharmacodynamics:

Loperamide, by binding to opioid receptors of the intestinal wall (modulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins). Slows down peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, helps to retain stool and reduce the urge to defecate. The action occurs quickly and lasts 4-6 hours.

Pharmacokinetics:

Almost completely metabolized by the liver by conjugation. The half-life (T1 / 2) is 9-14 hours. It is excreted mainly in the bile and kidneys (in the form of conjugated metabolites).

Indications for use:

• Symptomatic treatment of acute and chronic diarrhea of ??various origins (allergic, emotional, drug, radiation); with a change in the diet and the qualitative composition of food, with metabolic and absorption disorders;

• As an adjuvant for infectious diarrhea.

• Stool regulation in patients with ileostomy.

Contraindications:

• Hypersensitivity to the drug,

• diverticulosis,

• intestinal obstruction,

• ulcerative colitis in the acute stage,

• diarrhea against the background of acute pseudomembranous enterocolitis, in the form of monotherapy for dysentery and other infections of the gastrointestinal tract (GIT);

• pregnancy (I trimester),

• lactation period,

• children under 6 years old.

With care: liver failure.

Method of administration and dosage:

Inside, chewing with water.

For adults with acute and chronic diarrhea, an initial dose of 2 tablets (4 mg) is prescribed; then 1 tablet (2 mg) after each act of defecation (in the case of loose stools);

The maximum daily dose is 8 tablets (16 mg).

Children over 6 years of age with acute diarrhea are prescribed 1 tablet (2 mg) in the initial dose, then 1 tablet after each act of defecation (in the case of loose stools);

The maximum daily dose is 3 tablets (6 mg).

If stool normalizes or if there is no stool for more than 12 hours, treatment with Diara should be discontinued.

Side effect:

Gastralgia, dry mouth, allergic reactions (skin rash), drowsiness, dizziness, intestinal colic, nausea, vomiting, constipation. It is extremely rare - intestinal obstruction.

Overdose of the drug:

Symptoms: depression of the central nervous system (CNS) - stupor, impaired coordination of movements, drowsiness, miosis, muscle hypertension, respiratory depression; intestinal obstruction.

Treatment: antidote - naloxone; given that the duration of action of loperamide is longer than that of naloxone, it is possible to re-administer the latter.

Symptomatic treatment: activated charcoal, gastric lavage, artificial lung ventilation (ALV). Medical supervision is necessary for at least 48 hours.

Special instructions:

If there is no effect within 48 hours, the drug should be discontinued and a doctor should be consulted.

Release form:

Chewable tablets.

On 4, 6, 7 or 10 tablets in a blister strip packaging from a film of polyvinyl chloride and printed aluminum foil varnished.

1, 2 or 3 blister packs with instructions for use are placed in a cardboard box.

Storage conditions:

In a dry, dark place at a temperature not exceeding 25 ? C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after the expiry date stated on the package.

At the word of leave from pharmacies:

Without recipe.

Manufacturer:

CJSC Pharmaceutical Enterprise Obolenskoe,

142279, Moscow region, Serpukhov district, settlement Obolensk, building 7-8

Tel./fax (4967) 36-01-07

Company accepting claims:

CJSC Pharmaceutical Enterprise Obolenskoe,

142279, Moscow region, Serpukhov district, settlement Obolensk, building 7-8