Dezoksyrybonukleat sodium | Derinat 0.25% bottle, 10 ml

Packing

Bottle of 10 ml.

Pharmacological action

Derinat - immunomodulator.

It has a modulating effect on the cellular, humoral parts of the immune system and nonspecific resistance of the body, which leads to the optimization of the inflammatory response and the specific immune response to bacterial, viral and fungal antigens.

With pronounced lymphotropy, Derinat stimulates the drainage and detoxification function of the lymphatic system, primarily in the focus of the inflammatory reaction.

The drug activates antiviral, antifungal and antimicrobial immunity, stimulates reparative and regenerative processes, has an anti-inflammatory effect, normalizes the state of tissues and organs with dystrophy of vascular origin.

Derinat promotes the healing of trophic ulcers. In gangrenous processes under the influence of the drug, spontaneous rejection of necrotic masses in the lesions is noted (for example, on the phalanges of the fingers). Derinat promotes the rapid healing of infected wounds and deep burns.

Indications

As monotherapy: prevention and treatment of acute respiratory viral infections

ARI

inflammatory and dystrophic diseases of the eyes

inflammatory diseases of the oral mucosa.

As part of complex therapy: chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology

acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis / including frontal sinusitis, sinusitis /)

obliterating diseases of the lower extremities

trophic ulcers

gangrene

infected and nonhealing wounds (including diabetes mellitus)

burns

frostbite

postradiation necrosis of the skin and mucous membranes.

Contraindications

Hypersensitivity to the drug.

Use during pregnancy and lactation

The patient should be warned that a doctor should be consulted before using the drug during pregnancy and lactation. If necessary, the appointment of the drug during pregnancy should evaluate the expected benefits for the mother and the potential risk to the fetus.

Composition

1 ml of the solution contains:

Active ingredient: sodium deoxyribonucleate 2.5 g

Excipients: sodium chloride - 1 g water for injection - up to 1000 ml.

Dosage and Administration

Topically, topically.

The drug is prescribed for children from the first day of life and adults.

For the prevention of acute respiratory viral infections - in each nasal passage, 2 drops 2-4 times a day for 1 month. When symptoms of colds appear, every 1–1.5 hours during the day, then 2-3 drops in each nasal passage 3-4 times a day for 7–10 days (until recovery). In inflammatory diseases of the nasal cavity and paranasal sinuses - 3-5 drops in each nasal passage 3–6 times a day or cotton swabs with the drug are injected into each nasal passage 1-2 times a day for 5–10 minutes, the course duration is 1 –2 weeks

In chronic inflammatory fungal diseases, bacterial and other infections and violations of the integrity of the mucous membrane in gynecological practice - intravaginal administration followed by irrigation of the cervix or intravaginal administration of tampons with the drug, 5 ml per procedure 1-2 times a day for 10-14 days.

Inflammatory eye diseases of a viral and bacterial nature (conjunctivitis, keratitis, adenoviral keratoconjunctivitis, uveitis, maculitis, blepharitis) - 2 drops 4-6 times a day, course - from 10 days to 1-3 months.

Injuries to the organ of vision, to accelerate the healing process during surgical interventions - 2 drops 5 times a day, course - 1-3 months.

Irritation of the eyes (including “computer visual syndrome”), progressive myopia and accommodation spasm - 2 drops 3 times a day for a month.

For diseases of the oral mucosa (stomatitis, gingivitis, aphthous ulcers), rinse the drug 4-6 times a day (1 bottle - 1-2 rinses). The duration of treatment is 5-10 days.

In proctology, it is used in the form of microclysters into the rectum of 15–40 ml, the course is 7–14 days.

In case of post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene - apply dressings (gauze in two layers) to the affected areas with 3-4 times a day, with simultaneous instillation in the nose 1-2 drops 6 times a day (course of treatment - 1-3 months).

Side effects

Local reactions: moderate soreness at the injection site.

Possibly: hypoglycemia (in patients with diabetes mellitus) in some cases - within 1.5-3 hours after injections, short-term hyperthermia, stopped by the use of symptomatic agents.

Drug Interaction

Combined use with other drugs may enhance Derinat's therapeutic effect.

When used together, Derinate may enhance the action of anticoagulants.

Overdose

Not described.

Storage conditions

The drug is recommended to be stored in a dry, dark place at a temperature of 4 ° to 18 РC.

Expiration

5 years.

Terms of delivery from pharmacies

Over-the-counter