Dexavet 0.4% 100ml
DESCRIPTION
Dexavet 0.4% (Dexavetum) - solution for injection is used in animals with metabolic disorders. In appearance, the drug is a clear, colorless or slightly yellowish liquid.
COMPOSITION
1.0 cm? the drug contains as active ingredient 0.004 g of dexamethasone phosphate, excipients and fillers up to 1.0 cm.
PHARMACOLOGICAL PROPERTIES
Veterinary drug Dexavet 0.4% belongs to a group of drugs that affect metabolic processes - hormones.
Dexamethasone phosphate is a fluorinated analogue of hydrocortisone, more active than prednisolone and cortisone. It has a pronounced anti-inflammatory, anti-allergic, anti-edematous and gluconeogenetic effect.
The drug blocks the release of inflammatory mediators by eosinophils, including prostaglandins, which are involved in the development of the inflammatory process. Stimulates steroid receptors of lymphocytes, promoting the biosynthesis of lipocortins, which have anti-edematous activity; inhibits the proliferation of lymphoid tissue and cellular immunity, and also disrupts the chemotaxis of T-lymphocytes, reducing their cytotoxic activity.
The maximum concentration of dexamethasone in the blood is detected after 60 minutes. The therapeutic concentration in blood serum is maintained for 30-96 hours, depending on the type of animal. Intramuscular bioavailability is 100%. Biotransformation occurs in the liver and partially in fibroblasts involved in the metabolic process. Metabolites are mainly excreted through the liver and kidneys.
INDICATIONS
Dexavet 0.4% is used in animals with metabolic disorders (ketosis and toxemia after childbirth in ewes and sows); inflammatory processes, especially of the musculoskeletal system (arthritis, periarthritis, tendovaginitis, bursitis, dislocations, myositis, sprains); acute infectious diseases (in combination with antimicrobial agents); allergic conditions (atopic and contact dermatitis, urticaria, pruritus, conjunctivitis); laminitis in horses and cattle; with snake and insect bites; stressful (exhibitions, training) and shock conditions.
DOSAGE AND APPLICATION
Dexavet 0.4% is administered intramuscularly, preferably in the morning: horses and cattle - 5 cm?; pigs - 2-3 cm?; piglets, dogs and cats - 0.5-1 cm? once a day for three days. If necessary, the course of treatment should be continued.
SPECIAL INSTRUCTIONS
Slaughter of cattle and pigs for meat is allowed no earlier than 48 days, horses - after 24 days. Cow's milk can be used for food after 5 days. In the case of forced slaughter before the expiry of the waiting period, animal meat can be used as feed for carnivores.
When working with the veterinary drug Dexavet 0.4%, you should follow the general rules of personal hygiene and safety measures provided for when working with medicines.
SIDE EFFECTS
Subject to the dosage of the duration of use, the drug does not cause side effects. With prolonged use, Cushing's syndrome may develop, which causes redistribution of body fat, muscle weakness, weight loss and osteoporosis. The appearance of polyuria, polydipsia and polyphagia is possible. In the case of latent infections, the drug may exacerbate them.
CONTRAINDICATIONS
The drug is not used for diabetes mellitus, bone fractures, viral and fungal infections.
The drug is not used during the last trimester of pregnancy. The use of corticosteroids in lactating cows can cause a short-term decrease in milk production.
SHELF LIFE AND STORAGE
Shelf life, subject to storage conditions, is 2 years from the date of production. After opening the bottle, the drug is stored for 28 days. It is forbidden to use the drug Veterinary Dexavet 0.4% after the expiration date. The drug is stored according to list B in a dry, dark place at a temperature from + 50 В° C to + 25 В° C. Veterinary drug Dexavet 0.4% should be stored out of the reach of children.
PACKAGING
The drug is produced in sealed glass bottles of 100.0 ml. One transport package contains 50 pcs.
Specifications
KolVUP
50
Manufacturer
Belkarolin
Temperature regime
from +5 to +25
Teaser
used in animals with metabolic disorders