Dexafort 50 ml

DESCRIPTION

Dexafort (Dexafort) is a hormonal drug intended for relief of inflammatory processes and diseases with allergic and autoimmune etiology in animals. In appearance it is a white suspension.

COMPOSITION

Dexafort in 1 ml contains 2.67 mg of dexamethasone phenylpropionate and 1.32 mg of dexamethasone sodium phosphate (which is equivalent to 3 mg of dexamethasone) as active ingredients, and as auxiliary substances: sodium chloride - 4.0 mg, sodium citrate - 11.4 mg, benzyl alcohol - 10.4 mg, methylcellulose MH50 - 0.4 mg, tragacanth - 1.0 mg, sodium hydroxide and hydrochloric acid until a pH of 7.0-7.8 is reached, water for injection up to 1 ml.

PHARMACOLOGICAL PROPERTIES

Dexamethasone, which is part of Dexafort, is a synthetic analogue of the glucocorticosteroid hormone of the adrenal cortex - cortisol and has a more pronounced glucocorticosteroid effect, has anti-inflammatory, decongestant, desensitizing, antiallergic effect. The mechanism of action of the hormone is to block the release of inflammatory mediators by eosinophils, including prostaglandins, which potentiate the inflammatory process. Dexafort stimulates steroid receptors of lymphocytes, promoting the biosynthesis of lipocortins, which have anti-edematous activity. It inhibits the proliferation of lymphoid tissue and cellular immunity, and also disrupts the kinetics of T-lymphocytes, reducing their cytotoxic activity.

Dexafort is distinguished by its speed of action and duration of the effect. After intramuscular administration, dexamethasone disodium phosphate is immediately absorbed from the injection site. Dexamethasone phenylpropionate is absorbed more slowly and provides a lasting effect. The maximum concentration of dexamethasone in plasma is detected after 60 minutes.

The therapeutic concentration in blood serum is maintained for 30-96 hours, depending on the type of animal. Intramuscular bioavailability is 100%. Biotransformation occurs in the liver and partially in fibroblasts involved in the metabolic process. Metabolites are mainly excreted through the liver and kidneys.

According to the degree of impact on the body, Dexafort belongs to moderately hazardous substances (hazard class 3 according to GOST 12.1.007).

DOSAGE AND APPLICATION

Dexafort is used to relieve inflammatory processes and diseases with allergic and autoimmune etiology in animals (allergic dermatitis, eczema, post-traumatic edema, bronchial asthma, joint diseases, acute mastitis).

In cattle, horses, sheep, goats, pigs, Dexafort is administered once intramuscularly at a dose of 0.02 ml / kg (0.06 mg / kg), dogs and cats at a dose of 0.05 ml / kg (0.15 mg / kg ) intramuscularly or subcutaneously. Shake Dexafort thoroughly before use.

If necessary, Dexafort is re-injected after 7 days.

In the treatment of inflammations complicated by pathogenic and opportunistic bacterial microflora, Dexafort is prescribed only in combination with antibacterial drugs of a wide spectrum of action.

For the treatment of laminitis in horses, Dexafort is prescribed only in the very early stages of the disease.

SPECIAL INSTRUCTIONS

The peculiarities of the action at the first administration of the drug and at its cancellation were not revealed.

The drug is usually used once.

Overdose may cause drowsiness in horses.

To achieve a quick therapeutic effect in animals with high hypersensitivity or with a high risk of developing anaphylactic shock, it is recommended to use Dexafort together with antihistamines and / or adrenaline.

Slaughter of cattle for meat is allowed after 48 days, sheep, goats, pigs - after 60 days, horses - after 24 days. Milk obtained from animals can be used for food no earlier than after 5 days. In case of forced slaughter earlier than the specified time, animal meat can be used as feed for fur animals.

CONTRAINDICATIONS

Dexafort is contraindicated in viral and fungal infections, diabetes, osteoporosis, hyperadrenocorticism, kidney disease, heart failure. It is forbidden to use in animals with ulcerative lesions in the gastrointestinal tract, with corneal ulcers. Use with caution in the early stages of pregnancy, as this can cause fetal abnormalities.

Use in the last trimester of pregnancy is contraindicated, as this can lead to premature birth or abortion.

Dexafort should not be used concomitantly with vaccines due to the immunosuppressive effect of corticosteroids.

SIDE EFFECTS

As a rule, there are no side effects and complications when using Dexafort in accordance with this instruction. With prolonged use, Cushing's syndrome may develop, which causes redistribution of body fat, muscle weakness, weight loss and osteoporosis. The appearance of polyuria, polydipsia and polyphagia is possible. The use of corticosteroids in lactating cows can cause a short-term decrease in milk production.

SHELF LIFE AND STORAGE

Expiration date 36 months. Store at 15-25 В° C.

PACKAGING

50 ml glass vials packed in individual cardboard boxes.

Specifications

Bonus points

0

KolVUP

ten

Manufacturer

Intervet

Temperature regime

from +15 to +25

Teaser

hormonal drug intended for relief of inflammatory processes and diseases with allergic and autoimmune etiology in animals