Detrimax vitamin D3 tablets p / o 1000ME, No. 30 dietary supplement

As a biologically active food supplement - an additional source of vitamin D.

Adults - 1/2 tab. / Day with meals.

Duration of admission is 1 month.

One tablet contains:

Active ingredient: colecalciferol (vitamin D3) - 25 ?g (1000 IU)

Excipients: 2-substituted calcium ortho-phosphate (carrier), microcrystalline cellulose (E460, anti-caking agent).

Shell composition: hydroxypropyl methylcellulose (E464, carrier), titanium dioxide (E171, dye), polydextrose (E1200, stabilizer), talc (E553, anti-caking agent), maltodextrin, medium-chain triglycerides, magnesium stearic acid (stabilizer).

Individual intolerance to the components of the product.

pharmachologic effect

Detrimax Vitamin D3 contains vitamin D3 (colecalciferol) - a vital fat-soluble vitamin necessary for the functioning of almost all organs and systems of the human body. It is well absorbed in the gastrointestinal tract due to the formation of micellar compounds in the medium of the small intestine.

Vitamin D contributes to:

• maintaining healthy immune function;

• strengthening the musculoskeletal system;

• increasing the energy potential of the body;

• maintaining the normal functioning of the nervous system;

• maintaining normal reproductive function in both women and men.

Vitamin D plays a key role in:

The skeletal system . Participates in the regulation of phosphorus-calcium metabolism: helps to absorb calcium in the intestine, maintains the necessary levels of calcium and phosphorus in the blood, activates bone metabolism. Helps to ensure the strength of bones and teeth, reduce the risk of rickets, osteomalacia1,2.

Muscular system. Helps maintain muscle strength and neuromuscular conduction3, thereby reducing the risk of falls and fractures.

The immune system. Promotes the activation of healthy immune function, positively affecting both innate and acquired immunity. It starts the synthesis of its own antimicrobial peptides in the body: catalicidin and defensin. Helps reduce the risk of developing colds 4. It has a regulatory effect on the growth, development and renewal of cells5,6. Lack of vitamin D in the body leads to a weakening of the body's immune defenses.

Regulation of energy potential. Helps relieve fatigue and increase the tone of the body, regulating the cells' own energy potential As a result of the influence of vitamin D in the mitochondria of cells, the production of ATP (adenosine triphosphate) increases, which is its own universal source of energy for all biochemical processes in the body7.

The nervous system. It has a positive effect on the activity of the nervous system, including the psychoemotional sphere and cognitive functions: mood, memory, attention, performance, general tone of the body, since it participates in the production of neurotransmitters, biologically active substances through which nerve impulses are transmitted between nerve cells8. It is necessary for the conversion of tryptophan (an amino acid that enters the body with food) into serotonin, a neurotransmitter that is of great importance for normal cognitive function and psychoemotional state of a person. Promotes Mood Improvement 9. Vitamin D is able to have a positive effect on pain sensitivity due to a positive effect on the synthesis of neurotransmitters: serotonin, dopamine10.

Broncho-pulmonary system. Helps prevent airway smooth muscle changes, regulates airway smooth muscle contraction and inflammatory response, which contributes to normal lung function11.

Reproductive function. Stimulates the synthesis of female and male sex hormones: estrogen, progesterone, testosterone. It has a positive effect on reproductive function in both women and men12,13. For couples planning a pregnancy or having difficulty conceiving a child. In women with adequate levels of vitamin D3, egg fertilization occurs more frequently. The absence of vitamin D3 deficiency improves the results of IVF. Most likely, this effect is due to the effect of vitamin D3 on the endometrium. In addition, D3 plays an essential role in the correction of obesity and the course of the metabolic syndrome. Studies have found that maternal intake of vitamin D3 is associated with a lower risk of obstructive pulmonary disease in children.

Endocrine system. Vitamin D affects glucose and insulin metabolism, and vitamin D deficiency is a risk factor for the development of insulin resistance, impaired glucose tolerance. Vitamin D can stimulate the secretion of insulin by ?-cells of the pancreas, and also indirectly activates calcium-dependent ?-cell endopeptidase, which converts proinsulin into active insulin. Vitamin D can affect tissue insulin sensitivity by stimulating the expression of insulin receptors in cells14. Vitamin D has a positive effect on lipid metabolism, helping to reduce blood levels of total cholesterol, triglycerides and low-density lipids15.

Cardiovascular system. Vitamin D plays an important role in maintaining cardiovascular function. It has a positive effect on the inner layer and the muscular wall of blood vessels, as well as on the processes of blood coagulation16,17.

Epidemiological studies18 conducted in Russia have established that a reduced concentration of vitamin D in the blood is observed in 50-92% of the adult population of working age and children, regardless of the season of the year.

The reasons for the deficiency of vitamin D in most of the Russian population are both insufficient intake of it with food and a low level of its synthesis in the skin due to the geographical location of the territory of the Russian Federation (low insolation) 18.

Health Disorders Associated with Vitamin D Deficiency:

• the main manifestation of vitamin D deficiency in childhood is rickets, in adults - osteomalacia;

• in the elderly, vitamin D deficiency is primarily associated with muscle weakness and increased bone fragility.

The Food Safety Commission of the European Food Safety Authority has established a link between dietary intake of vitamin D and its contribution to the normal functioning of the immune system by the Commission on Diet, Nutrition and Allergy of the Food Committee of the European Food Safety Authority.

special instructions

It is recommended to consult a doctor before use.

special instructions

It is recommended to consult a doctor before use.

DetrimaxЃ Vitamin D3 has no contraindications for use during pregnancy, but it should be taken with caution.

Storage conditions

The product should be stored out of the reach of children at a temperature not exceeding 25 ? C.

Shelf life

Shelf life is 3 years.