Derinat solution for intramuscular injection 15mg / ml, 5ml No. 5

• Radiation damage;

• violation of hematopoiesis;

• myelodepression and resistance to cytostatics in cancer patients, developed against the background of cytostatic and / or radiation therapy (stabilization of hematopoiesis, reduction of cardio- and myelotoxicity of chemotherapy drugs);

• stomatitis induced by cytostatic therapy;

• peptic ulcer of the stomach and duodenum, erosive gastroduodenitis;

• Ischemic heart disease;

• obliterating diseases of the vessels of the lower extremities of the II-III stage;

• trophic ulcers, long-term non-healing wounds;

• odontogenic sepsis, purulent-septic complications;

• rheumatoid arthritis;

• burn disease;

• preoperative and postoperative periods (in surgical practice);

• chlamydia, ureaplasmosis, mycoplasmosis;

• endometritis, salpingo-oophoritis, endometriosis, fibroids;

• prostatitis, benign prostatic hyperplasia;

• chronic obstructive pulmonary disease;

• pulmonary tuberculosis, inflammatory diseases of the respiratory tract.

DerinatЃ is prescribed for adults intramuscularly (within 1-2 minutes) in an average single dose of 75 mg (5 ml of a solution for intramuscular administration of 15 mg / ml) with an injection interval of 24-72 hours.

With ischemic heart disease, 5 ml of a solution of 15 mg / ml is prescribed in / m after 48-72 hours, the course of treatment is 10 injections.

In case of gastric ulcer and duodenal ulcer, 5 ml of a solution of 15 mg / ml is prescribed in / m after 48 hours, the course of treatment is 5 injections.

For cancer - 5 ml (75 mg / day) intramuscularly after 24-72 hours, the course of treatment is 10 injections.

In gynecology (endometritis, chlamydia, ureaplasmosis, mycoplasmosis, salpingo-oophoritis, fibroids, endometriosis) - intramuscularly 5 ml of a solution of 15 mg / ml after 24-48 hours, the course of treatment is 10 injections.

In andrology (prostatitis, benign prostatic hyperplasia) - intramuscularly 5 ml of a solution of 15 mg / ml after 24-48 hours, the course of treatment is 10 injections.

In case of tuberculosis - intramuscularly 5 ml of a solution of 15 mg / ml after 24-48 hours, the course of treatment is 10-15 injections.

In acute inflammatory diseases - intramuscularly 5 ml of a solution of 15 mg / ml after 24-72 hours, the course of treatment is 3-5 injections.

In chronic inflammatory diseases - intramuscularly 5 ml of a solution of 15 mg / ml: the first 5 injections with an interval of 24 hours each, the next - each with an interval of 72 hours, the general course of treatment is 10 injections.

When using a solution of 15 mg / ml, 2 ml in / m, injections are carried out daily, making a recalculation, until a course dose of 375-750 mg is reached. In children, the frequency of intramuscular administration of the drug is the same as in adults.

For children under 2 years of age, the drug is prescribed in an average single dose of 7.5 mg (0.5 ml of a solution for intramuscular administration of 15 mg / ml);

for children aged 2 to 10 years, a single dose is determined at the rate of 0.5 ml of the drug per year of life;

for children over the age of 10, the average single dose is 75 mg (5 ml of a solution for intramuscular administration of 15 mg / ml), the course dose is up to 5 injections of the drug.

Solution for intramuscular injection is transparent, colorless, without impurities.

1 ml

sodium deoxyribonucleate

Excipients: sodium chloride (0.9 g), water d / and (up to 100 ml).

Hypersensitivity to the components of the drug.

pharmachologic effect

Immunomodulator affecting cellular and humoral immunity. The immunomodulatory effect of Derinat is due to the stimulation of B-lymphocytes, activation of T-helpers. DerinatЃ activates the body's nonspecific resistance, optimizing inflammatory responses and the immune response to bacterial, viral and fungal antigens. DerinatЃ stimulates reparative and regenerative processes. Increases the body's resistance to infections. Regulates hematopoiesis (normalizing the number of leukocytes, lymphocytes, granulocytes, phagocytes, platelets). Possessing a pronounced lymphotropicity, DerinatЃ stimulates the drainage and detoxification function of the lymphatic system. DerinatЃ significantly reduces the sensitivity of cells to the damaging effects of chemotherapy drugs and radiation therapy.

Pharmacokinetics

Absorption and distribution It is rapidly absorbed from the injection site with intramuscular injection and is distributed through the lymphatic tract in organs and tissues. Sodium deoxyribonucleate has a high tropism for the hematopoietic organs, takes an active part in cellular metabolism, integrating into cellular structures. It accumulates to the maximum in the bone marrow, lymph nodes, thymus, spleen, to a lesser extent - in the liver, brain, stomach, small and large intestine. In the phase of intensive drug intake into the blood, there is a redistribution between plasma and blood corpuscles, in parallel with metabolism and excretion. After a single injection, for all pharmacokinetic curves describing the change in the concentration of the drug in the studied organs and tissues,characterized by a rapid phase of increase and a rapid phase of decrease in concentration in the range of 5-24 hours. After intramuscular administration, Cmax is reached after 5 hours. The drug penetrates the BBB. Cmax of the drug in the brain is reached after 30 minutes. Metabolism and excretion Sodium deoxyribonucleate is metabolized in the body. It is excreted mainly by the kidneys and partially with feces. T1 / 2 with intramuscular injection is 72.3 hours.

Side effect

Perhaps: in patients with diabetes mellitus, a hypoglycemic effect is noted, which should be taken into account when controlling the level of glucose in the blood.

Application during pregnancy and lactation

The patient should be warned that a doctor's consultation is required before using the drug during pregnancy and lactation. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed.

Application in children

In children, the frequency of intramuscular administration of the drug is the same as in adults. For children under 2 years of age, the drug is prescribed in an average single dose of 7.5 mg (0.5 ml of a solution for intramuscular administration of 15 mg / ml), in children aged 2 to 10 years, a single dose is determined at the rate of 0.5 ml of the drug per year of life. In children over the age of 10, the average single dose is 75 mg (5 ml of a solution for intramuscular administration of 15 mg / ml), the course dose is up to 5 injections of the drug.

special instructions

The drug has no embryotoxic, teratogenic and carcinogenic effects. Perhaps s / c administration of the drug. The drug potentiates the therapeutic effect of basic therapy for gastric ulcer and duodenal ulcer. DerinatЃ reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis with a 50% and 70% improvement in a number of complex indicators of disease activity. In surgical sepsis, the introduction of Derinat into the complex therapy causes a decrease in the level of intoxication, activation of immunity, normalization of hematopoiesis, improves the functioning of the organs responsible for the processes of detoxification of the internal environment of the body (including lymph nodes, spleen). According to recent clinical studies, the effectiveness of Derinat has been proven in patients with exacerbation of COPD of varying severity against the background of standard therapy.Prescribe in / m 5 ml of a solution of 15 mg / ml after 24-48 hours, the course of treatment - 5-10 injections.

Overdose

Overdose symptoms were not observed.

Drug interactions

The use of Derinat in complex therapy allows to increase the effectiveness and shorten the duration of therapy, with a significant decrease in the doses of antibiotics and antiviral agents with an increase in the periods of remission. DerinatЃ increases the effectiveness of anthracycline antitumor antibiotics, cytostatics.