Derinat solution for external use 0.25%, 10ml

As monotherapy:

• prevention and treatment of ARVI;

• ARI;

• inflammatory and degenerative eye diseases;

• inflammatory diseases of the oral mucosa.

As part of complex therapy:

• chronic inflammatory diseases, fungal, bacterial and other infections of the mucous membranes in gynecology;

• acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis / including frontal sinusitis, sinusitis /);

• obliterating diseases of the lower extremities;

• trophic ulcers;

• gangrene;

• infected and long-term non-healing wounds (including diabetes mellitus);

• burns;

• frostbite;

• post-radiation necrosis of the skin and mucous membranes;

• hemorrhoids.

DerinatЃ in the form of a solution for external and local use is prescribed depending on the localization of the pathological process.

The drug is prescribed for children from the first day of life and for adults.

For the prevention of ARVI, 2 drops are instilled into each nasal passage 2-4 times / day for 1-2 weeks. When symptoms of a respiratory disease appear, the drug is instilled in 2-3 drops into each nasal passage every 1-1.5 hours during the first day, then 2-3 drops in each nasal passage 3-4 times / day. The duration of the course of therapy is from 5 days to 1 month.

For inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times / day; the duration of the course is 7-15 days.

In case of inflammatory diseases of the oral cavity, rinse the mouth with a solution of the drug 4-6 times / day (1 bottle for 2-3 rinses). The duration of the course of therapy is 5-10 days.

For chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - intravaginal administration of tampons with the drug or irrigation of the vagina and cervix, 5 ml per procedure 1-2 times / day for 10-14 days.

For hemorrhoids, the drug is administered rectally using microclysters, 15-40 ml each. The duration of the course of treatment is 4-10 days.

In ophthalmic practice in severe inflammatory and dystrophic processes DerinatЃ is instilled into the eyes 1-2 drops 2-3 times / day for 14-45 days.

In case of obliterating diseases of the lower extremities, in order to achieve a systemic effect, the drug is instilled in 1-2 drops into each nasal passage 6 times / day, the duration of the course is up to 6 months.

With post-radiation necrosis of the skin and mucous membranes, with long-term non-healing wounds, burns, frostbite, trophic ulcers of various etiologies, gangrene on the affected areas, it is recommended to apply application dressings (gauze in 2 layers) with the application of the drug 3-4 times / day or carry out the treatment of the affected surface with a preparation from a nebulizer 10-40 ml 4-5 times / day. The course of treatment is 1-3 months.

Solution for external and local use 0.25% transparent, colorless, without foreign inclusions.

1 ml sodium deoxyribonucleate 2.5 mg

Excipients: sodium chloride, water d / i.

hypersensitivity to the components of the drug.

pharmachologic effect

Immunomodulator affecting cellular and humoral immunity. DerinatЃ stimulates reparative processes, has an anti-inflammatory effect, normalizes the state of tissues in case of degenerative changes in vascular genesis.

The drug activates antiviral, antifungal and antimicrobial immunity, has a high reparative and regenerative effect.

When applied externally, DerinatЃ promotes the healing of trophic ulcers, infected wounds and deep burns, significantly accelerating epithelialization. Under the influence of Derinat, scarless healing of ulcerative defects on the mucous membrane occurs.

Pharmacokinetics

Absorption and distribution

Sodium deoxyribonucleate is rapidly absorbed when applied topically and is distributed through the lymphatic pathways in organs and tissues.

Metabolism and excretion

Sodium deoxyribonucleate is metabolized in the body. It is excreted mainly by the kidneys and partially with feces.

Side effect

With external and local application of the drug, side effects were not identified.

Application during pregnancy and lactation

The patient should be warned that a doctor's consultation is required before using the drug during pregnancy and lactation. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be assessed.

special instructions

In the course of numerous experimental and clinical laboratory studies, the absence of mutagenic, teratogenic, embryotoxic, carcinogenic, allergenic properties, cytogenetic effects has been proven; revealed its moderate antimutagenic action.

With gangrenous processes under the action of the drug, spontaneous rejection of necrotic masses in the foci of rejection with restoration of the skin is noted. With open wounds and burns, an analgesic effect is noted.

Overdose

To date, no cases of overdose of DerinatЃ have been reported.

Drug interactions

When applied topically, it is incompatible with fat-based ointments and hydrogen peroxide.