Decaris tablets 150mg, No. 1

• Infections with helminths Ascaris lumbricoides , Necator Americanus and Ancylostoma duodenale.

Inside, after eating, with a little water, in the evening.

Tablets 50 mg: children 3-6 years old (10-20 kg) - 25-50 mg (1 / 2-1 tab.) 6-10 years old (20-30 kg) - 50-75 mg (1-1.5 table); 10-14 years (30-40 kg) - 75-100 mg (1.5-2 tablets) once.

Tablets 150 mg: for adults - 1 tablet, 150 mg once.

There is no need for laxatives or a special diet. If necessary, taking the drug can be repeated after 7-14 days.

Active ingredient:
One tablet of Decaris contains 150 mg of levamisole (as 177 mg of levamisole hydrochloride).

Excipients for tablets 150 mg: corn starch, lactose monohydrate, sucrose, talc, povidone, magnesium stearate.

• Hypersensitivity to one of the components of the drug;

• agranulocytosis caused by drugs (history);

• children under 3 years old;

• lactation period.

For 150 mg tablets, children's age is a contraindication!

• Pregnancy For pregnant
  women, prescribe the drug only if the expected benefit outweighs the possible risk of using the drug.

• Lactation Period
  To protect the newborn, it is necessary to decide whether to stop breastfeeding or stop taking the drug, depending on how much the mother needs to take the drug.
  Take with caution in hepatic and / or renal failure, inhibition of bone marrow hematopoiesis.

Trade name: DECARIS

International non-proprietary name:

LEVAMIZOL

Dosage form:

pills

Composition

Active ingredient:
One tablet of Decaris contains 150 mg of levamisole (as 177 mg of levamisole hydrochloride).
Excipients for tablets 150 mg: corn starch, lactose monohydrate, sucrose, talc, povidone, magnesium stearate.

Description:

Tablets 150 mg - Round, flat, off-white tablets, beveled and engraved with DECARIS 150 on one side.

Pharmacotherapeutic group:

Anthelmintic agent

Pharmacological properties

Pharmacodynamics
The active substance of Decaris - levamisole is an anthelmintic agent. Acting on ganglion-like formations of nematodes, Dekaris causes depolarizing neuromuscular paralysis of the membrane of helminth muscles, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of bioenergetic processes of helminths. Thus, paralyzed nematodes are removed from the body by normal intestinal peristalsis within 24 hours after taking the drug.
Pharmacokinetics
Levamisole, when taken orally at a dose of 50 mg, is rapidly absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is determined, on average, 1.5-2 hours after taking the drug. Levamisole undergoes intensive metabolism in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide.
The half-life from the body is 3-6 hours. Unchanged excreted in urine less than 5%, with feces less than 0.2% of the administered dose.

Indications for use

• Infections with helminths Ascaris lumbricoides , Necator Americanus and Ancylostoma duodenale.

Contraindications

• Hypersensitivity to one of the components of the drug;

• agranulocytosis caused by drugs (history);

• children under 3 years old;

• lactation period.

• For 150 mg tablets, children's age is a contraindication!

• Pregnancy For pregnant
  women, prescribe the drug only if the expected benefit outweighs the possible risk of using the drug.

• Lactation Period
  To protect the newborn, it is necessary to decide whether to stop breastfeeding or stop taking the drug, depending on how much the mother needs to take the drug.
  Take with caution in hepatic and / or renal failure, inhibition of bone marrow hematopoiesis.

Method of administration and dosage

Tablets 50 mg:
Children from 3 to 6 years old (10-20 kg) - 25-50 mg (1 / 2-1 tablet); from 6 to 10 years old (20-30 kg) 50-75 mg (1-1.5 tablets); from 10 to 14 years old (30-40 kg) - 75-100 mg (1.5-2 tablets) once.
It is advisable to take the drug after meals with a little water, in the evening.
There is no need for laxatives or a special diet. If necessary, taking the drug can be repeated after 7-14 days.

Tablets 150 mg
Adults are prescribed one tablet of 150 mg once. It is advisable to take the drug after meals with a little water, in the evening. There is no need for laxatives or a special diet. If necessary, taking the drug can be repeated after 7-14 days.

Overdose

Symptoms
With the introduction of a large dose of levamisole (over 600 mg), the following signs of intoxication have been described: nausea, vomiting, drowsiness, convulsions, diarrhea, headache, dizziness and confusion.
Treatment
In case of accidental overdose - if not much time has passed after taking the drug - you can flush the stomach. It is necessary to monitor vital signs and conduct symptomatic therapy.
If there are signs of anticholinesterase action, atropine can be administered.

Side effect

Headache, insomnia, dizziness, palpitations, convulsions, dyspeptic symptoms such as nausea, vomiting, abdominal pain, diarrhea.
There are reports of the development of phenomena from the central nervous system (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), convulsions.
In most patients, this phenomenon was reversible, and early use of glucocorticosteroid therapy improved the prognosis.
The connection of these symptoms with the use of Decaris is not entirely convincing. When using large doses or with prolonged therapy, leukopenia, agranulocytosis, tremor may occur.

Interaction with other medicinal products.

With the simultaneous administration of the drug with alcoholic beverages, disulfiram-like phenomena are observed.
Caution is required when using Decaris with drugs that affect hematopoiesis.
With the simultaneous administration of the drug with coumarin-like anticoagulants, the prothrombin time may lengthen, therefore it is necessary to adjust the dose of the oral anticoagulant.
Decaris increases the level of phenytoin in the blood, therefore, with their simultaneous use, it is necessary to control the level of phenytoin in the blood. Decaris cannot be used simultaneously with lipophilic drugs such as carbon tetrachloride, tetrachlorethylene, chenopodium oil, chloroform or ether, as its toxicity may increase.

special instructions

During and after taking the drug, you should not drink alcohol for 24 hours.
It has not been proven that levamisole, used as an anthelmintic agent, inhibits the nervous system.

The effect of the drug on the ability to drive a car and other mechanisms

Due to the fact that when taking the drug, transient, mild dizziness may occur, caution should be exercised when driving a car or when working with mechanisms during the entire course of treatment.

Release form

Tablets 150 mg. 1 tablet in a blister made of PVC and aluminum foil. 1 blister with instructions for use in a cardboard box.

Storage conditions

At a temperature of 15-30 ? C.
Keep out of the reach of children.

Shelf life

5 years. Do not use the drug after the expiry date indicated on the package.

Conditions of dispensing from pharmacies

On prescription.