Dakarbazyn | Dacarbazine-RENEVEN for injection lyophil. 100 mg vials 1 pc.

Special Price $18.62 Regular Price $26.00
In stock
SKU
BID496443
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Latin name

DACARBAZIN-LANS
Latin name

DACARBAZIN-LANS

Release form

Lyophilisate for solution for iv administration.

Packing

Bottle 0.1 g of lyophilisate. In the package 1 bottle.

Pharmacological action

Pharmacodynamics

Antitumor agent alkylating action. Interacts with SH groups. It inhibits the synthesis of purine bases and DNA.

Pharmacokinetics

Low protein binding. Penetrates through the BBB in limited quantities. Intensively metabolized in the liver. T1 / 2 in the initial phase is 19 minutes, in the final - 5 hours. With impaired renal and hepatic function, T1 / 2 increases. It is excreted by the kidneys unchanged and in the form of metabolites - 40% for 6 hours.

Indications

Malignant melanoma

lymphogranulomatosis

soft tissue sarcoma.

It is possible to use it as a second-line drug in:

testicular tumors

malignant neoplasms of the gastrointestinal tract and neuroblastoma.

Contraindications

Myelodepression

pregnancy

hypersensitivity to dacarbazine.

Use during pregnancy and lactation

Dacarbazine is contraindicated in pregnancy. If necessary, use during lactation, breastfeeding should be discontinued.

Women of childbearing age should use reliable methods of contraception.

Experimental studies have revealed the toxic effects of dacarbazine on the fetus.

Composition

1 vial contains:

Active ingredient: Dacarbazine 100 mg

Excipients: citric acid 100 mg

mannitol 50 mg

Dosage and administration

Set individually, depending on the indications and stage of the disease, the state of the hematopoietic system, anti-tumor therapy regimen.

Side effects

From the hematopoietic system: leukopenia, thrombocytopenia, anemia.

From the digestive system: anorexia, nausea, vomiting, diarrhea, stomatitis in some cases - impaired liver function, hepatic vein thrombosis, toxic liver dystrophy.

From the reproductive system: amenorrhea, azoospermia.

Dermatological reactions: alopecia, skin rash.

Other: hyperemia, facial hypesthesia in isolated cases - impaired renal function.

After a single dose at a high dose: the development of a flu-like syndrome is possible, accompanied by fever and myalgia.

Drug Interaction

Taking 200 mg of ketoconazole once daily increases the plasma concentration of orally administered budesonide at a dose of 3 mg by an average of 6 times. When ketoconazole is administered 12 h after budesonide administration, the concentration of the latter

When used with phenobarbital, azathioprine or 6-mercaptopurine, the toxic effect of dacarbazine is increased.

Storage conditions

Store in a dry, dark place at 2-8 РC.

Shelf life

2 years.

Deystvuyushtee substance

Dacarbazine

Terms and conditions

prescription

Dosage form

infusion solution

Possible product names

Dakarbazin-Lance 100mg lyoph.por. d / in / in. Fl. X1 B (R)

DAKARBAZIN-LENS LIOF. POR. 100 MG FL. No. 1

Dakarbazin-LENS vials 0.1 g, 1 pc.

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