Cyanocobalamin solution for injection 0.5mg / ml, 1ml No. 10

Anemia due to B12-deficiency conditions; as part of complex therapy for iron deficiency and posthemorrhagic anemia; aplastic anemia caused by toxic substances and drugs; liver diseases (hepatitis, cirrhosis); funicular myelosis; polyneuritis; radiculitis; neuralgia; amyotrophic lateral sclerosis; cerebral palsy; Down's disease; peripheral nerve injury; skin diseases (psoriasis, photodermatosis, dermatitis herpetiformis, neurodermatitis); for the prevention and treatment of symptoms of vitamin B12 deficiency (including when using biguanides, PASK, vitamin C in high doses); radiation sickness.

Enter s / c, i / m, i / v and intralumbar, as well as inside. For anemia associated with vitamin B12 deficiency, 100-200 mcg is administered every other day. For anemia with symptoms of funicular myelosis and for macrocytic anemias with diseases of the nervous system - 400-500 mcg in the first 7 days daily, then once every 5-7 days. During remission, in the absence of funicular myelosis, the maintenance dose is 100 mcg 2 times a month, in the presence of neurological symptoms - 200-400 mcg 2-4 times a month.

In acute post-hemorrhagic and iron deficiency anemia - 30-100 mcg 2-3 times a week. With aplastic anemias (especially in children) - 100 mcg before the onset of clinical improvement. With alimentary anemia in young children and in premature infants - 30 ?g / day for 15 days.

In diseases of the central and peripheral nervous system, neurological diseases with pain syndrome, it is administered in increasing doses - 200-500 ?g, with improvement of the condition - 100 ?g / day. The course of treatment is 2 weeks. With traumatic lesions of the peripheral nervous system - 200-400 mcg every other day for 40-45 days.

With hepatitis and cirrhosis of the liver - 30-60 mcg / day or 100 mcg every other day for 25-40 days.

With dystrophies in young children, Down's disease and cerebral palsy - 15-30 mcg every other day.

With funicular myelosis, amyotrophic lateral sclerosis, 15-30 ?g can be administered into the spinal canal, gradually increasing the dose to 200-250 ?g.

With radiation sickness, diabetic neuropathy, sprue - 60-100 mcg daily for 20-30 days.

With a deficiency of vitamin B12 for prophylaxis - i / m or i / v 1 mg once a month; for treatment - 1 mg intramuscularly or intravenously, 1 mg daily for 1-2 weeks, a maintenance dose of 1-2 mg intramuscularly or intravenously - from 1 time per week to 1 time per month. The duration of treatment is set individually.

cyanocobalamin 0.5 mg

Excipients : sodium chloride 9 mg, water d / i - up to 1 ml.

Thromboembolism, erythremia, erythrocytosis, hypersensitivity to cyanocobalamin.

pharmachologic effect

Vitamin B12 belongs to the group of water-soluble vitamins. Possesses high biological activity. It is necessary for normal hematopoiesis (promotes the maturation of red blood cells). Participates in the processes of transmethylation, hydrogen transfer, the formation of methionine, nucleic acids, choline, creatine. Promotes the accumulation of compounds containing sulfhydryl groups in erythrocytes. Has a beneficial effect on the function of the liver and nervous system. Participates in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with damage to the peripheral nervous system, stimulates nucleic acid metabolism through the activation of folic acid. It activates the blood coagulation system, in high doses causes an increase in the activity of thromboplastin and prothrombin.

Pharmacokinetics

After oral administration, it is absorbed from the gastrointestinal tract. It is metabolized in tissues, turning into a coenzyme form - adenosylcobalamin, which is the active form of cyanocobalamin. It is excreted in the bile and in the urine.

Indications of the active substances of the drug Cyanocobalamin

Anemia due to B12-deficiency conditions; as part of complex therapy for iron deficiency and posthemorrhagic anemia; aplastic anemia caused by toxic substances and drugs; liver diseases (hepatitis, cirrhosis); funicular myelosis; polyneuritis; radiculitis; neuralgia; amyotrophic lateral sclerosis; cerebral palsy; Down's disease; peripheral nerve injury; skin diseases (psoriasis, photodermatosis, dermatitis herpetiformis, neurodermatitis); for the prevention and treatment of symptoms of vitamin B12 deficiency (including when using biguanides, PASK, vitamin C in high doses); radiation sickness.

Dosage regimen

Enter s / c, i / m, i / v and intralumbar, as well as inside. For anemia associated with vitamin B12 deficiency, 100-200 mcg is administered every other day. For anemia with symptoms of funicular myelosis and for macrocytic anemias with diseases of the nervous system - 400-500 mcg in the first 7 days daily, then once every 5-7 days. During remission, in the absence of funicular myelosis, the maintenance dose is 100 mcg 2 times a month, in the presence of neurological symptoms - 200-400 mcg 2-4 times a month.

In acute post-hemorrhagic and iron deficiency anemia - 30-100 mcg 2-3 times a week. With aplastic anemias (especially in children) - 100 mcg before the onset of clinical improvement. With alimentary anemia in young children and in premature infants - 30 ?g / day for 15 days.

In diseases of the central and peripheral nervous system, neurological diseases with pain syndrome, it is administered in increasing doses - 200-500 ?g, with improvement of the condition - 100 ?g / day. The course of treatment is 2 weeks. With traumatic lesions of the peripheral nervous system - 200-400 mcg every other day for 40-45 days.

With hepatitis and cirrhosis of the liver - 30-60 mcg / day or 100 mcg every other day for 25-40 days.

With dystrophies in young children, Down's disease and cerebral palsy - 15-30 mcg every other day.

With funicular myelosis, amyotrophic lateral sclerosis, 15-30 ?g can be administered into the spinal canal, gradually increasing the dose to 200-250 ?g.

With radiation sickness, diabetic neuropathy, sprue - 60-100 mcg daily for 20-30 days.

With a deficiency of vitamin B12 for prophylaxis - i / m or i / v 1 mg once a month; for treatment - 1 mg intramuscularly or intravenously, 1 mg daily for 1-2 weeks, a maintenance dose of 1-2 mg intramuscularly or intravenously - from 1 time per week to 1 time per month. The duration of treatment is set individually.

Side effect

From the side of the central nervous system: rarely - a state of excitement.

From the side of the cardiovascular system: rarely - pain in the region of the heart, tachycardia.

Allergic reactions: rarely - urticaria.

Contraindications for use

Thromboembolism, erythremia, erythrocytosis, hypersensitivity to cyanocobalamin.

Application during pregnancy and lactation

Cyanocobalamin can be used during pregnancy as indicated.

Application in children

Application is possible according to the dosage regimen.

special instructions

For angina pectoris, it should be used with caution in a single dose of no more than 100 mcg. During treatment, you should regularly monitor the blood picture and clotting.

Drug interactions

With simultaneous use with hormonal contraceptives for oral administration, it is possible to reduce the concentration of cyanocobalamin in the blood plasma.

With simultaneous use with anticonvulsants, the absorption of cyanocobalamin from the intestine decreases.

With simultaneous use with neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, potassium preparations, the absorption of cyanocobalamin from the intestine decreases.

With parenteral administration, chloramphenicol can reduce the hematopoietic effect of cyanocobalamin in anemia.