Cozaar tablets 100mg, No. 28

arterial hypertension;

a decrease in the risk of associated cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy, manifested by a cumulative decrease in the incidence of cardiovascular mortality, stroke and myocardial infarction;

protection of renal function in patients with type 2 diabetes mellitus with proteinuria - slowing the progression of renal failure, manifested by a decrease in the incidence of hypercreatininemia; the incidence of end-stage chronic renal failure (CRF) requiring hemodialysis or kidney transplantation and mortality rates;

chronic heart failure with ineffective treatment with ACE inhibitors or intolerance to ACE inhibitors.

Inside, regardless of food intake.

Cozaar can be taken in combination with other antihypertensive drugs. To ensure the required dosage regimen, it is possible to take the drug Kozaar at a dose of 50 mg.

Arterial hypertension. The standard starting and maintenance dose for most patients is 50 mg of Cozaar once a day.

The maximum antihypertensive effect is achieved 3Ц6 weeks after the start of therapy. In some patients, to achieve a greater effect, the dose may be increased to a maximum daily dose of 100 mg of Cozaar once a day. In patients with reduced BCC (for example, when taking large doses of diuretics), the initial dose of losartan should be reduced to 25 mg 1 time per day (see 'Special instructions').

There is no need to adjust the initial dosage in elderly patients and patients with renal insufficiency, including patients on dialysis.

Patients with a history of liver disease are advised to prescribe lower doses of the drug (see 'Special instructions').

Reducing the risk of associated cardiovascular morbidity and mortality in patients with arterial hypertension and left ventricular hypertrophy. The standard starting dose of Kozaar is 50 mg once a day. In the future, it is recommended to add hydrochlorothiazide in low doses or increase the dose of Cozaar to a maximum daily dose of 100 mg 1 time per day, taking into account the degree of blood pressure reduction.

Kidney protection in patients with type 2 diabetes mellitus and proteinuria. The standard initial dose of Kozaar is 50 mg once a day. In the future, it is recommended to increase the dose of Kozaar to the maximum daily dose of 100 mg 1 time per day, taking into account the degree of blood pressure reduction.

The drug Kozaar can be prescribed in combination with other antihypertensive drugs (diuretics, CCBs, ?- and ?-adrenergic blockers, central antihypertensive drugs for oral administration), insulin and other hypoglycemic agents (sulfonylurea derivatives, glitazones and glucosidase inhibitors).

Chronic heart failure. The initial dose of Kozaar for patients with CHF is 12.5 mg once a day. As a rule, the dose is titrated at weekly intervals (i.e. 12.5, 25, 50, 100 mg / day, up to a maximum dose of 150 mg once a day), depending on individual tolerance.

hypersensitivity to any of the components of this drug;

simultaneous use with aliskiren in patients with diabetes mellitus (see 'Interaction');

severe liver dysfunction (no experience with use);

hereditary lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;

pregnancy and the period of breastfeeding;

age up to 18 years (efficacy and safety of use have not been established).

With care: bilateral renal artery stenosis or stenosis of an artery of a single kidney; hyperkalemia; conditions after kidney transplantation (no experience with use); aortic or mitral stenosis; obstructive hypertrophic cardiomyopathy; heart failure with concomitant severe renal failure; severe heart failure (NYHA functional class IV); heart failure with life-threatening arrhythmias; coronary heart disease; cerebrovascular diseases; primary hyperaldosteronism; a history of angioedema. Patients with reduced BCC (for example, receiving treatment with large doses of diuretics) may experience symptomatic arterial hypotension.