Corvalol Phyto tablets, No. 50

Sleep disturbances, neurosis-like states, accompanied by increased irritability and excitability, states of arousal with pronounced vegetative manifestations; as an antispasmodic agent for intestinal spasms, and also as a symptomatic (sedative and vasodilator) agent for functional disorders of the cardiovascular system.

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

The drug is taken orally, before meals, after dissolving in a small amount (30-40 ml) of water.

Adults are prescribed 30 drops 3 times / day.

The course of treatment is 28 days. The duration of admission can be increased on the recommendation of a doctor.

Active ingredients:

motherwort extract (motherwort extract dry)

ethyl bromisovalerianate (alpha-bromisovaleric acid ethyl ester)

peppermint oil

Severe renal and / or liver dysfunction; erosive and ulcerative lesions of the gastrointestinal tract (exacerbation phase); pregnancy; lactation period; age up to 18 years (efficacy and safety have not been established); hypersensitivity to the components of the drug.

Precautions: abnormal liver and / or kidney function; epilepsy; alcoholism; high-risk patients, incl. with liver diseases, craniocerebral trauma, brain diseases.

Tablets are round, flat-cylindrical, light brown in color, interspersed with a lighter and darker color, beveled and scored, with a weak characteristic odor.

Composition:

Active ingredients:

motherwort extract (motherwort extract dry) - 14 mg

ethyl bromisovalerianate (ethyl ester of alpha-bromisovaleric acid) - 8.2 mg

peppermint oil - 0.58 mg

Excipients: lactose (lactose monohydrate) - 79.21 mg, betadex (betacyclodextrin) - 55.55 mg, potato starch - 35.56 mg, magnesium aluminometasilicate (Neusilin UFL 2) - 4 mg, talc - 2 mg, magnesium stearate - 0.9 mg.

Tablets are round, flat-cylindrical, light brown in color, interspersed with a lighter and darker color, beveled and scored, with a weak characteristic odor.

Active ingredients:

motherwort extract (motherwort extract dry) - 28 mg

ethyl bromisovalerianate (ethyl ester of alpha-bromisovaleric acid) - 16.4 mg

peppermint oil - 1.16 mg

Excipients : lactose (lactose monohydrate) - 158.42 mg, betadex (betacyclodextrin) - 111.1 mg, potato starch - 71.12 mg, magnesium aluminometasilicate (Neusilin UFL 2) - 8 mg, talc - 4 mg, magnesium stearate - 1.8 mg.

Pharmaco-therapeutic group: Sedative

pharmachologic effect

Combined drug, the action of which is due to the properties of its constituent substances. It has a sedative and antispasmodic effect, a moderate cardiotonic effect, and has moderate antihypertensive properties.

Ethyl alpha-bromisovalerate has a sedative and antispasmodic effect due to irritation mainly of receptors in the oral cavity and nasopharynx, a decrease in reflex excitability in the central parts of the nervous system and an increase in inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the vasomotor center and direct local spasmolytic action on smooth muscles.

Motherwort herb has a pronounced sedative, moderate cardiotonic effect, moderate hypotensive effect.

Peppermint oil has a reflex vasodilating, antispasmodic, slight choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the 'cold' receptors of the oral mucosa and reflexively expand the vessels of the heart and brain. Eliminates the phenomenon of flatulence due to irritation of the receptors of the gastrointestinal mucosa, enhancing intestinal motility.

Indications

Sleep disturbances, neurosis-like states, accompanied by increased irritability and excitability, states of arousal with pronounced vegetative manifestations; as an antispasmodic agent for intestinal spasms, and also as a symptomatic (sedative and vasodilator) agent for functional disorders of the cardiovascular system.

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.

The drug is taken orally, before meals, after dissolving in a small amount (30-40 ml) of water.

Adults are prescribed 30 drops 3 times / day.

The course of treatment is 28 days. The duration of admission can be increased on the recommendation of a doctor.

Side effect

From the immune system: allergic reactions.

From the nervous system: drowsiness, weakness, dizziness, decreased ability to concentrate.

From the side of the cardiovascular system: slowing down of the heart rate.

From the digestive system: dyspepsia.

These phenomena disappear when the dose of the drug is reduced or the drug is stopped.

With prolonged use of the drug in high doses , drug dependence may develop, as well as the accumulation of bromine in the body and the development of phenomena of bromism, the manifestations of which are depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.

Contraindications for use

Severe renal and / or liver dysfunction; erosive and ulcerative lesions of the gastrointestinal tract (exacerbation phase); pregnancy; lactation period; age up to 18 years (efficacy and safety have not been established); hypersensitivity to the components of the drug.

Precautions: abnormal liver and / or kidney function; epilepsy; alcoholism; high-risk patients, incl. with liver diseases, craniocerebral trauma, brain diseases.

Application during pregnancy and lactation

The use of the drug during pregnancy is contraindicated.

If it is necessary to use the drug during lactation, the question of stopping breastfeeding should be resolved.

Application for violations of liver function

The use of the drug is contraindicated in severe liver dysfunction.

The drug should be prescribed with caution in case of liver dysfunction.

Application for impaired renal function

The use of the drug is contraindicated in severe renal impairment.

The drug should be prescribed with caution in case of impaired renal function.

Application in children

The use of the drug under the age of 18 is contraindicated (efficacy and safety have not been established).

special instructions

Long-term use of the drug in high doses is not recommended, due to the possible toxic effect during the accumulation of bromine in the body.

You should not drink alcohol while using the drug.

The drug contains 47.5% ethanol, so when taken orally in the maximum single dose of the drug, the ethanol content is 0.308 g, in the maximum daily dose - 0.923 g.

Influence on the ability to drive vehicles and use mechanisms

In connection with the possibility of dizziness, decreased concentration and other side effects associated with taking the drug, during the period of treatment, patients are advised to refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor and motor reactions.

Drug interactions

With the simultaneous use of the drug with drugs that inhibit the activity of the central nervous system (sedatives, hypnotics, antipsychotics, tranquilizers), mutual enhancement of the effects is possible.

The drug enhances the effect of antispasmodic, analgesic agents .

Ethanol enhances the effect of the drug and its toxicity.