Corilip suppositories, No. 10

As monotherapy or as an addition to basic therapy for various pathological conditions in children, including:

• chronic tissue hypoxia;

• decreased immunity;

• bacterial and viral infections;

• chronic somatic diseases;

• chronic intoxication;

• conditions after suffering serious illnesses;

• malnutrition (malnutrition).

Periods of intensive growth and the formation of new functions in a child, with intense physical and mental stress, in stressful situations.

As a fortifying agent for prophylaxis during an epidemic of infectious diseases.

The drug is used rectally. Having freed from the packaging, the suppository should be inserted into the anus (after preliminary emptying of the intestines).

Newborns and infants are prescribed 1/2 suppository / day; children aged 1 to 6 years) - 1 suppository / day; children aged 6 to 14 years old - 1-2 suppositories / day.

The duration of the course of treatment is 10 days. The total duration of treatment is 3-4 courses with an interval of 20 days (3-4 months).

Rectal suppositories are yellow with possible splashes of orange-yellow, torpedo-shaped.

1 supp.

cocarboxylase hydrochloride 25 mg

riboflavin 2 mg

thioctic (?-lipoic) acid 12 mg

Excipients: cocoa butter or solid fat.

• proctitis;

• rectal bleeding;

• hypersensitivity to the components of the drug.

pharmachologic effect

A drug with a general strengthening effect. A combined preparation, the action of which is determined by the effects of the vitamins and coenzymes included in its composition, as well as by the synergism of the action.

Cocarboxylase hydrochloride (coenzyme) catalyzes the carboxylation and decarboxylation of ?-keto acids, participates in the processes of carbohydrate metabolism, through participation in the pentose cycle, indirectly promotes the synthesis of nucleic acids, proteins, lipids. Activates tissue exchange. The drug is used for correction in metabolic acidosis, cellular hypoxia, other metabolic disorders, in case of insufficiency of liver, kidney, cardiovascular system, chronic intoxication.

Riboflavin (vitamin B2) as a coenzyme of flavin proteins is involved in the regulation of redox reactions, as well as in the processes of carbohydrate, protein and fat metabolism; plays an important role in the synthesis of hemoglobin and the maintenance of normal visual function of the eye, the state of the mucous membranes and skin.

Lipoic acid is involved in the oxidative decarboxylation of pyruvic acid and ?-keto acids, in the regulation of lipid and carbohydrate metabolism, and plays an important role in the formation of energy in the body. Lipoic acid has a hepatoprotective effect, improves the detoxification function of the liver, protects against the effects of exo- and endotoxins.

Corilip improves tissue metabolism in various physiological and pathological conditions that require correction with cofactors and substrates.

Side effect

Allergic reactions: rarely - urticaria, itching, bronchospasm, dyspepsia.

If adverse reactions occur, the patient should stop taking the drug and consult a doctor.

Application in children

The drug is intended for use in children.

special instructions

The criteria for the duration of treatment, along with the clinical state, are the cytochemical indicators of the activity of enzymes of peripheral blood leukocytes (succinate dehydrogenase and glycerophosphate dehydrogenase).

Overdose

Data on overdose of the drug Corilip are not provided.

Drug interactions

No negative interaction was noted.

The drug can be used in combination therapy.