Comfoderm ointment d / nar. approx. 0.1% tube 30g
Category
Psoriasis
Scope of the drug
Dermatology
Release form
Ointment
Manufacturer country
Russia
Package quantity, pcs
one
Release form
Ointment for external use 0.1% from white or to white with a grayish or yellowish tinge, a characteristic odor is allowed.
pharmachologic effect
GCS for external use.
Suppresses the function of leukocytes and tissue macrophages.
Limits the migration of leukocytes to the area of inflammation.
Violates the ability of macrophages to phagocytosis, as well as the formation of interleukin-1.
Promotes the stabilization of lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation.
Reduces capillary permeability due to the release of histamine.
Suppresses fibroblast activity and collagen formation.
Inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes.
Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.
Reduces the number of circulating lymphocytes (T and B cells), monocytes, eosinophils and basophils due to their movement from the vascular bed into the lymphoid tissue
inhibits the formation of antibodies.
Methylprednisolone aceponate inhibits the release of ACTH and β-lipotropin by the pituitary gland, but does not reduce the level of circulating β-endorphin.
Inhibits the secretion of TSH and FSH.
When applied directly to the vessels, it causes a vasoconstrictor effect.
When applied topically and locally, the therapeutic activity of methylprednisolone is due to its anti-inflammatory, antiallergic and antiexudative (due to the vasoconstrictor effect) action.
Indications
Inflammatory skin diseases sensitive to topical glucocorticosteroid therapy:
atopic dermatitis, neurodermatitis, childhood eczema
true eczema
microbial eczema
professional eczema
simple contact dermatitis
allergic (contact) dermatitis
dyshidrotic eczema.
Contraindications
Tuberculous or syphilitic processes in the area of application of the drug
viral diseases (for example, chickenpox, shingles), in the area of application of the drug
rosacea, perioral dermatitis in the area of application of the drug
children's age up to 4 months
areas of the skin with manifestations of a reaction to vaccination
hypersensitivity to the components of the drug.
Application during pregnancy and during breastfeeding
If you need to use the drug Comfoderm during pregnancy and during breastfeeding, you should carefully weigh the potential risk to the fetus and the expected benefits of treatment for the mother.
During these periods, long-term use of the drug on large skin surfaces is not recommended nursing mothers should not apply the drug to the mammary glands.
Structure
100 g
methylprednisolone aceponate (in terms of 100% substance) 100 mg
Excipients: petroleum jelly - 44.7 g, liquid paraffin - 34.1 g, castor bean seed oil - 3.2 g, white beeswax - 17.9 g.
Method of administration and dosage
Apply externally 1 time / day with a thin layer on the affected area, rubbing slightly.
Can be used with an occlusive dressing.
Typically, the course of treatment for adults is no more than 12 weeks, and for children - no more than 4 weeks.
Several courses of therapy are possible during the year.
Overdose
When studying the acute toxicity of megilprednisolone aceponate, there was no risk of acute intoxication with excessive single skin use (application of the drug over a large area under conditions favorable for absorption) or unintentional ingestion.
With excessively long and / or intensive use of glucocorticosteroids for external use, skin atrophy (thinning of the skin, telangiectasia, striae) may develop
Active substance
Methylprednisolone aceponate
Storage conditions
The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Do not use after the expiration date.
Name ENG
KOMFODERM
Clinical and pharmacological group
Anti-inflammatory drug for external use
ATX code
Methylprednisolone aceponate
Dosage
0.1% x 30g
Structure
100 g methylprednisolone aceponate (in terms of 100% substance) 100 mg Excipients: petroleum jelly - 44.7 g, liquid paraffin - 34.1 g, castor bean seed oil - 3.2 g, white beeswax - 17.9 g.
Indications
Inflammatory skin diseases sensitive to therapy with topical glucocorticosteroids: atopic dermatitis, neurodermatitis, childhood eczema true eczema microbial eczema occupational eczema simple contact dermatitis allergic (contact) dermatitis dyshidrotic eczema
INN / Active ingredient
methylprednisolone aceponate
Contraindications
Uberculous or syphilitic processes in the area of drug application
viral diseases (for example, chickenpox, shingles), in the area of application of the drug
rosacea, perioral dermatitis in the area of application of the drug
children's age up to 4 months
areas of the skin with manifestations of a reaction to vaccination
hypersensitivity to the components of the drug.
Storage conditions and periods
At a temperature not higher than 25 degrees.
Expiration date: 2 years
Specifications
Category
Psoriasis
Scope of the drug
Dermatology
Release form
Ointment
Manufacturer country
Russia
Package quantity, pcs
one
Scope of application
Dermatology
,
Allergology
Minimum age from
4 months
Way of introduction
Locally
,
Outwardly
Vacation conditions
Without recipe
Brand name
Akrikhin
The amount of the dosage form in the primary package
30 g
Primary packaging type
Tuba
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Topical glucocorticosteroid
Anatomical and therapeutic characteristics
D07AC14 Methylprednisolone aceponate
Dosage form
Ointment for external use
Packaging
Cardboard box
Expiration date in days
730
The target audience
Children
Package weight, g
thirty
Mode of application
:
Apply externally 1 time / day with a thin layer on the affected area, rubbing slightly.
Can be used with an occlusive dressing.
Typically, the course of treatment for adults is no more than 12 weeks, and for children - no more than 4 weeks.
Several courses of therapy are possible during the year.
Dosage (volume) of the substance in the preparation
:
methylprednisolone aceponate (in terms of 100% substance) 100 mg
Information on technical characteristics, delivery set, country of manufacture