Coldact Flu plus caps. prolong. action # 10

Release form, composition and packaging

?

Sustained-release capsules 1 cap.

phenylephrine hydrochloride 25 mg

chlorphenamine (chlorpheniramine) maleate 8 mg

paracetamol 200 mg

10 pieces.

- blisters (1) - cardboard packs.

pharmachologic effect

The combined preparation of prolonged action.

Chlorphenamine has antiallergic effect, eliminates tearing, itching in the eyes and nose.

Paracetamol has an antipyretic and analgesic effect: it reduces the pain syndrome observed in colds - sore throat, headache, muscle and joint pain, reduces high temperature.

Phenylephrine has a vasoconstrictor effect - it reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses. ''

Indications for use

- symptomatic treatment of colds, flu, SARS (febrile syndrome, pain syndrome, rhinorrhea).

Contraindications for use

- hypersensitivity to any of the constituent components

- severe atherosclerosis of the coronary arteries

- arterial hypertension

- diabetes

- thyrotoxicosis

- angle-closure glaucoma

- severe diseases of the liver, kidneys, heart, bladder

- peptic ulcer of the stomach and duodenum

- diseases of the pancreas

- Difficulty urinating with prostate adenoma

- diseases of the blood system

- deficiency of glucose-6-phosphate dehydrogenase

- children under 12 years old.

With caution: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), bronchial asthma and chronic obstructive pulmonary disease.

Dosage regimen

Adults and children over 12 years old - 1 capsule every 12 hours for 3-5 days.

Duration of use as an antipyretic agent - no more than 3 days

as an anesthetic - no more than 5 days.

Overdose

Symptoms caused by paracetamol appear after taking more than 10-15 g: pallor of the skin, decreased appetite, nausea, vomiting, hepatonecrosis, increased activity of hepatic transaminases, increased prothrombin time.

Treatment: gastric lavage in the first 6 hours, administration of SH-group donors and precursors of glutathione-methionine synthesis 8-9 hours after the overdose and N-acetylcysteine ​​after 12 hours. In case of accidental overdose, you should immediately consult a doctor, regardless of which - either symptoms of an overdose or not.

Side effect

Increased blood pressure, tachycardia, drowsiness, sleep disturbance, dizziness, hyperexcitability, dry mucous membranes, mydriasis, accommodation paresis, increased intraocular pressure, impaired appetite, nausea, epigastric pain, anemia.

Very rare: urinary retention, allergic reactions (skin rash, itching, urticaria, angioedema).

Rarely: anemia, thrombocytopenia, leukemia, agranulocytosis.

With prolonged use in high doses, hepatotoxic and nephrotic effects are possible.

Drug interactions

The risk of developing the hematotoxic effect of paracetamol increases with the simultaneous administration of barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of liver microsomal enzymes.

Enhances the effects of sedatives, ethanol, MAO inhibitors.

Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic drugs increase the risk of urinary retention, dry mouth, and constipation.

GCS increase the risk of developing glaucoma.

Paracetamol reduces the effectiveness of uricosuric drugs.

Chlorphenamine simultaneously with furazolidone can lead to hypertensive crisis, agitation, hyperrexia.

Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine, the simultaneous administration of halothane increases the risk of ventricular arrhythmia.

Reduces hypotension

Dosage

200mg + 25mg + 8mg

Structure

Active ingredients: Chlorphenamine maleate 8 mg.

Paracetamol 200 mg.

Phenylephrine hydrochloride 25 mg.

Auxiliary ingredients: talc 68.25 mg, hypromellose 4.5 mg, ethyl cellulose 29 mg, diethyl phthalate 5.8 mg, microcrystalline cellulose 28.01 mg, povidone - 6.41 mg, purified water * qs, isopropanol * qs, sodium disulfite 0.16 mg, disodium edetate 0.32 mg, crimson dye (Ponso 4R) 0.35 mg, sunset yellow dye 0.01 mg, quinoline yellow dye 0.08 mg, Non Pareil Seeds18 / 22 granules (sugar grains: sucrose, starch syrup) 124.11 mg.

Capsule shell: gelatin qs up to 100%, purified water 14-15%, methyl parahydroxybenzoate 0.2%, azorubin dye 0.35%, crimson dye (Ponso 4R) 0.47%.

* lost during production

INN / Active ingredient

chlorphenamine (chlorpheniramine) maleate, phenylephrine hydrochloride, paracetamol

Storage conditions and periods

At a temperature not higher than 25 degrees.

Specifications

Category

Pain and fever

,

Runny nose

Scope of the drug

Ear, Throat, Nose

Dosage (volume) of the substance in the preparation

25 mg + 8 mg + 200 mg

Release form

Capsules

Manufacturer country

India

Package quantity, pcs

ten

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Ranbaxy

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Dosage form

Sustained release capsules

Expiration date in days

730

A type

Medicine

The target audience

Children

Package weight, g

thirty

Mode of application

:

Adults and children over 12 years old - 1 capsule every 12 hours for 3-5 days. < br> < br> Duration of taking as an antipyretic agent - no more than 3 days

as an anesthetic - no more than 5 days.

Pharmaco-therapeutic group

:

ARI and cold" symptoms remedy (analgesic non-narcotic drug + alpha-adrenergic agonist + H1-histamine receptor blocker)

Anatomical and therapeutic characteristics

:

N02BE51 Paracetamol, in combination with other drugs (excluding psychotropic drugs)

Information on technical characteristics, delivery set, country of manufacture "