Cofasma syrup, 200ml

Acute and chronic bronchopulmonary diseases, accompanied by difficulty in sputum discharge:

COPD (bronchial asthma, obstructive bronchitis, pulmonary emphysema);

tracheobronchitis;

pneumonia;

pneumoconiosis;

pulmonary tuberculosis.

Inside, adults and children over 12 years old are prescribed 10 ml (2 teaspoons) 3 times / day, children under 6 years old - 5 ml (1 teaspoon) 3 times / day, from 6 to 12 years old - 5 -10 ml (1-2 teaspoons) 3 times / day.

Syrup in the form of an orange liquid with a pineapple odor.

10 ml

salbutamol (in the form of sulfate) 2 mg

bromhexine hydrochloride 4 mg

guaifenesin 100 mg

Excipients: levomenthol - 1 mg, propylene glycol - 2050 mg, aspartame - 60 mg, sodium benzoate - 20 mg, citric acid - 40 mg, sodium citrate dihydrate - 22.8 mg, sunset yellow dye - 0.15 mg, pineapple flavor - 0.01 ml , hypromellose - 70 mg, purified water - up to 10 ml.

• Tachyarrhythmia;

• myocarditis;

• aortic stenosis;

• decompensated diabetes mellitus;

• thyrotoxicosis;

• glaucoma;

• hepatic and / or renal failure;

• peptic ulcer of the stomach and duodenum (in the acute stage);

• arterial hypertension;

• stomach bleeding;

• pregnancy;

• lactation period;

• hypersensitivity to the components of the combination.

• With caution Diabetes mellitus, arterial hypertension, gastric ulcer and duodenal ulcer (history); simultaneous use of antitussives, non-selective ?-adrenergic receptor blockers and MAO inhibitors.

pharmachologic effect

The combined drug has a bronchodilator, expectorant and mucolytic effect.

Salbutamol is a bronchodilator that stimulates ?2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces resistance in the airways, increases the vital capacity of the lungs. It causes expansion of the coronary arteries, does not lower blood pressure.

Bromhexine is a mucolytic agent that has an expectorant and antitussive effect. Increases the serous component of bronchial secretions; activates the cilia of the ciliated epithelium, reduces the viscosity of sputum, increases its volume and improves discharge.

Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the broncho-pulmonary apparatus; stimulates the secretory cells of the bronchial mucosa, producing neutral polysaccharides, depolymerizes acidic mucopolysaccharides, reduces the viscosity of sputum, activates the bronchial ciliary apparatus, facilitates the removal of sputum and promotes the transition of an unproductive cough into a productive one.

Side effect

From the nervous system: headache, dizziness, increased nervous irritability, sleep disturbances, drowsiness, tremors, convulsions.

From the digestive system: nausea, vomiting, diarrhea, exacerbation of gastric ulcer and duodenal ulcer, increased activity of hepatic transaminases (extremely rare).

From the side of the cardiovascular system: tachycardia, decreased blood pressure, collapse.

From the urinary system: urine staining pink.

Allergic reactions: skin rash, urticaria, paradoxical bronchospasm.

Application during pregnancy and lactation

Use during pregnancy and lactation (breastfeeding) is contraindicated.

Application for violations of liver function

Contraindication - liver failure.

Application for impaired renal function

Contraindication - renal failure.

Application in children

Application is possible according to the dosage regimen.

special instructions

Guaifenesin stains urine pink.

It is not recommended to be taken simultaneously with alkaline drinks.

Drug interactions

Theophylline and other xanthines, when used simultaneously, increase the likelihood of developing tachyarrhythmias.

MAO inhibitors and tricyclic antidepressants enhance the effect of salbutamol, can lead to a sharp decrease in blood pressure.

Anticholinergics given by inhalation can cause an increase in intraocular pressure.

The drug is incompatible with non-selective beta-blockers.

Diuretics and corticosteroids enhance the hypokalemic effect of salbutamol.

Simultaneous administration with drugs containing codeine and other antitussives makes it difficult for the liquefied sputum to pass.

Bromhexine, which is part of the drug, promotes the penetration of antibiotics into the lung tissue.

It is not recommended to use concomitantly with nonselective ?-adrenoreceptor blockers.