clindamycin | Zerkalin bottle 10 mg / ml, 30 ml

Special Price $19.40 Regular Price $28.00
In stock
SKU
BID468378
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Release form

Solution for external use alcohol
Release form

Solution for external use alcohol

Packaging

30 ml in a dark glass bottle with a dropper and a screw cap. Each dropper bottle, together with instructions for medical use, is placed in a cardboard box.

Pharmacological action

Pharmacotherapeutic group

Antibiotic-lincosamide.

ATX code: D10AF01

Pharmacological properties of

Pharmacodynamics

Clindamycin is an antibiotic of the lincosamide group, active against all strains of Propionibacteriumacnes, the minimum inhibitory concentration (MIC) is 0.4 μg / ml. It inhibits the synthesis of proteins in a microbial cell due to interaction with the 50S subunits of ribosomes. After application to the skin, the amount of free fatty acids on the surface of the skin decreases from about 14 to 2%.

Pharmacokinetics

Clindamycin rapidly accumulates in comedones, where it exhibits antibacterial activity. The average concentration of antibiotic in the comedone content after application of the solution is significantly higher than the minimum inhibitory concentration for all strains of Propionibacteriumacnes, the causative agent of acne. After applying a solution of clindamycin hydrochloride in the blood plasma and urine to the skin, very low concentrations of clindamycin are determined.

Indications

The drug is used to treat acne (acnevulgaris).



contraindications hypersensitivity to clindamycin or lincomycin in the history of

in patients with antibiotic antibiotic iirovannym colitis in history

age of 12 years.

Precautions

Caution should be used in patients with a predisposition to allergic reactions.

Use during pregnancy and lactation

Clinical data on the use of the drug in pregnant and lactating women are limited. In animal studies, teratogenic effects of clindamycin were not established, and embryotoxic and fetotoxic effects were observed only after oral administration of clindamycin in high doses. Since studies of reproductive toxicity in animals do not always allow predicting a response in humans, the drug can be used during pregnancy, if the potential benefit to the mother outweighs the potential risk to the fetus.

Despite the fact that after external use of the drug Zerkalin® in breast-feeding women, its blood level is much lower than after taking clindamycin inside, the decision to stop breastfeeding or to stop using the drug should be made taking into account the assessment of the importance of the drug for the mother and risk to the child.

Special instructions

Avoid contact with the drug on the mucous membrane of the eyes and oral cavity. After applying the drug, wash your hands thoroughly. In case of accidental contact with sensitive surfaces (eyes, abrasions on the skin, mucous membranes) rinse this area with plenty of cool water.

The use of clindamycin (as well as other antibiotics) orally or parenterally in some cases is associated with the development of severe diarrhea and pseudomembranous colitis. With topical use of clindamycin, cases of diarrhea and colitis are rare, however, caution should be exercised, and if severe or prolonged diarrhea develops, the drug should be discontinued and appropriate diagnostic and therapeutic measures should be carried out if necessary.

If necessary, please consult your doctor before using the medicine.

Effect on ability to drive vehicles,

mechanisms ZerkalinВ® does not affect the ability to drive vehicles or engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Dosage and Administration

Externally. The solution is applied to the affected area of ​​previously cleaned and dried skin 2 times a day, morning and evening.

Course of treatment: to obtain satisfactory results, treatment should be continued for 6-8 weeks, and if necessary, can be continued for up to 6 months.

If there is no improvement after treatment or if new symptoms appear, consult a doctor.

Use the drug only according to the method of use and at the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Side effects

Classification of side reactions by organs and organ systems with an indication of their frequency of occurrence: very often (? 1/10), often (? 1/100,

Disorders of the skin and subcutaneous tissues

Very often: dry skin, skin irritation, urticaria

Often: seborrhea

Frequency unknown: contact dermatitis.

Disorders of gastrointestinal tract

Infrequent: digestive disturbance

Frequency unknown: pseudomembranous colitis, abdominal pain

Infectious and parasitic diseases

Frequency unknown: folliculitis

Visual disturbances

Frequency unknown: any of the pain in the eyes. inst side effects are aggravated or other side effects are noted that are not listed in the instructions, you should immediately inform your doctor immediately

Drug Interactions

The simultaneous use of clindamycin with other drugs for the treatment of acne containing exfoliating emollients and abrasives (e.g. benzoyl peroxide, tretinoin, resorcinol, salicylic acid, sulfur) due to possible irritating effects on the skin.

There is cross-resistance of microorganisms to clindamycin and lincomycin. Antagonism between clindamycin and erythromycin has been observed. It has been established that clindamycin during systemic use disrupts neuromuscular transmission and, therefore, can enhance the effect of other peripheral muscle relaxants, therefore, despite the external use of Zerkalin®, its blood level is significantly lower than after oral administration of clindamycin, the drug should use with caution in patients receiving drugs of this group.

overdose

When used externally, clindamycin can be absorbed in amounts that cause systemic effects. Possible systemic side effects include diarrhea, hemorrhagic diarrhea, including pseudomembranous colitis. In case of overdose, symptomatic and supportive therapy is indicated.

Storage conditions

Do not store above 25 РC out of the reach of children.

Shelf life

3 years.

Deystvuyushtee substance

Clindamycin

Terms and conditions

without prescription

Appointment

Children older than 12 years, children prescribed by a doctor for adults prescribed by a doctor,rdlkp Children over 12 years old, For adults

Indications

Indications

Acne, Skin infections

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