Citovir-3 orange powder d / pr-ra 20g, No. 1

Inside, 30 minutes before meals.

For treatment

Children aged 1 to 3 years - 2 ml 3 times / day; children aged 3 to 6 years - 4 ml 3 times / day; children aged 6 to 10 years - 8 ml 3 times / day; children over the age of 10 years - 12 ml 3 times / day. The course of application is 4 days. If after 3 days of treatment there is no improvement or the symptoms worsen, or new symptoms appear, you should consult your doctor. For prophylaxis In direct contact with a patient with influenza and other acute respiratory viral infections: for children aged 1 to 3 years - 2 ml of solution 3 times / day; for children aged 3 to 6 years - 4 ml 3 times / day; for children aged 6 to 10 years - 8 ml 3 times / day; for children over the age of 10 years - 12 ml 3 times / day. The course of application is 4 days. Prophylactic courses, if necessary, are repeated after 3 weeks (until the epidemic situation returns to normal).Rules for the preparation of a solution for oral administration Add 40 ml of water (boiled, cooled to room temperature) into a bottle of powder, shake well. The content should completely dissolve. The volume of the solution after adding water is 50 ml. The drug should be taken only according to the method of administration and in the doses indicated in the instructions. If necessary, you should consult your doctor before taking the drug. The drug should be used only according to the indications specified in the instructions.which are indicated in the instructions. If necessary, you should consult your doctor before taking the drug. The drug should be used only according to the indications specified in the instructions.which are indicated in the instructions. If necessary, you should consult your doctor before taking the drug. The drug should be used only according to the indications specified in the instructions.

alpha-glutamyl-tryptophan sodium (in terms of alpha-glutamyl-tryptophan) 0.15 mg

ascorbic acid 12 mg

bendazole hydrochloride 1.25 mg

hypersensitivity to drug components; lactase deficiency, lactose intolerance, sucrase / isomaltase deficiency, glucose-galactose malabsorption; pregnancy; children's age up to 1 year.

If necessary, the patient should consult a doctor before taking the drug.

Carefully:

with arterial hypotension, diabetes mellitus and intolerance to certain sugars, the patient should consult a doctor before taking the drug.

pharmachologic effect

The drug is a means of etiotropic and immunostimulating therapy, has an indirect antiviral effect against influenza A and B viruses, as well as other viruses that cause acute respiratory viral diseases. Reduces the severity of the main clinical symptoms of influenza and SARS, and also reduces the duration of the manifestation of symptoms of the disease and contributes to its uncomplicated course. Increases the content of secretory immunoglobulin A (sIgA) in the nasopharyngeal mucosa - the entrance gate of infection, increasing the body's local immunoresistance to respiratory infections of viral and bacterial nature. With a prophylactic effect, the drug increases the potential metabolic activity of cells of innate immunity (neutrophilic granulocytes and monocytes), which, in the event of an infection,increases their ability to absorb and destroy bacterial and viral agents by increasing enzymatic (oxidative) activity, synthesis of cationic proteins and increasing the number of phagocytic cells. At the same time, the initial state of metabolic activity of cells of innate immunity, in the absence of infectious agents, does not change, being within normal values. Bendazol induces the production of endogenous interferon in the body, has an immunomodulatory effect (normalizes the body's immune response). Enzymes, the production of which is induced by interferon in cells of various organs, inhibit viral replication. Alpha-glutamyl-tryptophan (thymogen) is a synergist of the immunomodulatory action of bendazole, normalizing the T-cell link of immunity. Ascorbic acid activates the humoral link of immunity,normalizes capillary permeability, thereby reducing inflammation, and exhibits antioxidant properties, neutralizing oxygen radicals accompanying the inflammatory process, increases the body's resistance to infection.

Pharmacokinetics

Absorption and distribution When taken orally, the drug is completely absorbed from the gastrointestinal tract. Bioavailability of bendazole is about 80%, alpha-glutamyl-tryptophan is no more than 15%, ascorbic acid is up to 70%. Ascorbic acid is absorbed from the gastrointestinal tract (mainly in the jejunum). Plasma protein binding - 25%. Tmax after oral administration - 4 hours. It easily penetrates into leukocytes, platelets, and then into all tissues, penetrates the placental barrier. Diseases of the gastrointestinal tract (peptic ulcer and duodenal ulcer, intestinal motility disorders, helminthic invasion, giardiasis), the use of vegetable and fruit juices, alkaline drinks reduce the binding of ascorbic acid in the intestine. Metabolism and excretion Ascorbic acid is metabolized mainly in the liver with the formation of deoxyascorbic, then oxaloacetic and diketogulonic acids.It is excreted by the kidneys, through the intestines, with sweat, breast milk in unchanged form and in the form of metabolites. Biotransformation products of bendazole in the blood are two conjugates formed as a result of methylation and carboethoxylation of the imino group of the imidazole ring of bendazole: 1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole. Bendazole metabolites are excreted in the urine. Alpha-glutamyl-tryptophan is broken down by peptidases into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole. Bendazole metabolites are excreted in the urine. Alpha-glutamyl-tryptophan is broken down by peptidases into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.1-methyl-2-benzylbenzimidazole and 1-carboethoxy-2-benzylbenzimidazole. Bendazole metabolites are excreted in the urine. Alpha-glutamyl-tryptophan is broken down by peptidases into L-glutamic acid and L-tryptophan, which are used by the body in protein synthesis.

Side effect

From the side of the cardiovascular system: possibly - a short-term decrease in blood pressure. Allergic reactions: possibly urticaria (in such cases, the use of the drug is stopped and symptomatic treatment, antihistamines are prescribed). If you experience the above or any other side effects, you should consult your doctor. If these side effects worsen, you should inform your doctor.

Application during pregnancy and lactation

The drug is contraindicated for use in pregnancy due to insufficient clinical data. During breastfeeding, use is possible if the intended benefit to the mother outweighs the potential risk to the child. If you need to take the drug during breastfeeding, you should consult your doctor.

Application in children

Contraindications: children under 1 year of age.

Overdose

Overdose cases are not described.

Drug interactions

The interaction of alpha-glutamyl-tryptophan with drugs has not been identified. Bendazol prevents an increase in OPSS caused by the use of non-selective beta-blockers. Strengthens the hypotensive effect (lowering blood pressure) of antihypertensive and diuretic drugs. Phentolamine enhances the hypotensive effect of bendazole. Ascorbic acid increases the concentration of tetracycline antibiotics and benzylpenicillin in the blood. Improves intestinal absorption of iron preparations. Reduces the effectiveness of heparin and indirect anticoagulants. Acetylsalicylic acid (ASA), oral contraceptives, fresh juices, and alkaline drinks reduce absorption and absorption. With simultaneous use with ASA, urinary excretion of ascorbic acid increases and ASA excretion decreases. ASA reduces the absorption of ascorbic acid by about 30%.Ascorbic acid increases the risk of crystalluria when using drugs containing ASA and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood. With simultaneous use, it reduces the chronotropic effect of isoprenaline. Reduces the therapeutic effect of antipsychotics (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Possible simultaneous use with antiviral drugs and symptomatic therapy for influenza and acute respiratory viral infections. If the patient is taking the above drugs or other drugs,he should consult a doctor.