Ciprofloxacin | Ciprofloxacin vials 2 mg / ml, 100 ml
Special Price
$12.61
Regular Price
$21.00
In stock
SKU
BID472282
Release form
Infusion solution.
Infusion solution.
Release form
Infusion solution.
Packing
bottle 100 ml zrdldp7777 100rd zrdrdp7777 bottle zrdrdp7777
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to ciprofloxacin: respiratory tract
ear, throat and nose
kidney and urinary tract
genital organs
digestive system (including mouth, teeth, jaws)
gall bladder and biliary tract
skin, mucous membranes and soft tissues
musculoskeletal system.
Ciprofloxacin is indicated for the treatment of sepsis and peritonitis, as well as for the prevention and treatment of infections in immunocompromised patients (with immunosuppressive therapy).
Contraindications
hypersensitivity to the drug ciprofloxacin
pseudo
glucose-6-phosphate dehydrogenase deficiency
fetal colitis
childhood up to 18 years of age (before the skeletal formation process increased srdl fluoroquinolone drugs.
With caution, the drug should be prescribed for severe cerebral arteriosclerosis, cerebrovascular accidents, mental illness, convulsive syndrome, epilepsy, severe renal and / or liver failure, elderly patients.
Use during pregnancy and lactation
Ciprofloxacin is contraindicated in pregnancy and lactation (breastfeeding).
Special instructions
If severe and prolonged diarrhea occurs during or after treatment with ciprofloxacin, the diagnosis of pseudomembranous colitis should be excluded, which requires immediate withdrawal of the drug and appropriate treatment.
During the treatment with ciprofloxacin, it is necessary to provide a sufficient amount of fluid while observing normal diuresis.
During treatment with ciprofloxacin, contact with direct sunlight should be avoided.
In patients with a history of seizures, a history of seizures, vascular diseases, and organic brain damage due to the risk of developing adverse reactions from the central nervous system, ciprofloxacin should be prescribed only for health reasons.
If severe and prolonged diarrhea occurs during or after treatment with ciprofloxacin, the diagnosis of pseudomembranous colitis should be excluded, which requires immediate withdrawal of the drug and the appointment of appropriate treatment.
If you experience pain in the tendons or when the first signs of tendovaginitis appear, treatment should be discontinued due to the fact that isolated cases of inflammation and even rupture of tendons during treatment with fluoroquinolones have been described.
Influence on the ability to drive vehicles and operate machinery
Patients taking Ciprofloxacin should be careful when driving a car and engaging in other potentially dangerous activities that require increased attention and speed of psychomotor reactions (especially while drinking alcohol).
Composition
Active ingredient: ciprofloxacin hydrochloride monohydrate (in terms of ciprofloxacin) - 2.0 mg.
Excipients: sodium chloride - 9.0 mg, disodium edetate dihydrate (disodium salt of ethylenediaminetetraacetic acid, Trilon B) - 0.10 mg, lactic acid (in terms of 100% substance) - 0.64 mg, water for injection - up to 1 ml.
Dosage and administration
The drug should be administered intravenously dropwise for 30 minutes (dose 200 mg) and 60 minutes (dose 400 mg).
The infusion solution can be combined with 0.9% sodium chloride solution, Ringer's solution, 5% and 10% dextrose (glucose) solution, 10% fructose solution, a solution containing 5% dextrose solution with 0.225% or 0.45% sodium chloride solution.
A single dose is 200 mg, with severe infections - 400 mg. The frequency of administration is 2 times / day, the duration of treatment is 1-2 weeks, if necessary, an increase in the course of treatment is possible.
In acute gonorrhea, the drug is administered intravenously once at a dose of 1000 mg.
For the prevention of postoperative infections - 30-60 minutes before surgery intravenously at a dose of 200-400 mg.
Patients with severe renal failure (CC must be prescribed half the daily dose.
Side effects
From the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with past liver diseases), hepatitis, hepatonecrosis.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, fatigue, anxiety, tremors, insomnia, nightmares, peripheral paralgesia (anomaly in the perception of pain), sweating, increased intracranial pressure, anxiety, confusion, depression, hallucinations manifestations of psychotic reactions (sometimes progressing to conditions in which the patient may harm himself), migraine, fainting, cerebral artery thrombosis.
On the part of the sensory organs: impaired taste and smell, impaired vision (diplopia, color perception), tinnitus, hearing loss.
From the cardiovascular system: tachycardia, cardiac arrhythmias, decreased blood pressure, flushing of the face.
From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
On the part of laboratory parameters: hypoprothrombinemia, increased activity of hepatic transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
From the urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, decreased kidney excretory function, interstitial nephritis.
From the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia.
Allergic reactions: skin itching, urticaria, the formation of blisters, accompanied by bleeding, scab-forming papules, drug fever, spot hemorrhages (petechiae), swelling of the face or larynx, shortness of breath, eosinophilia, increased photosensitivity, vasculitis, erythema nodosum, exudative erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis).
Other: arthralgia, arthritis, tendovaginitis, tendon ruptures, general weakness, myalgia, superinfection (candidiasis, pseudomembranous colitis), pain and burning sensation at the injection site, phlebitis.
Drug interaction
Due to the decrease in the activity of microsomal oxidation processes in hepatocytes, ciprofloxacin increases the concentration and lengthens the half-life of theophylline and other xanthines (e.g. caffeine), oral hypoglycemic drugs, indirect anticoagulants, and helps to reduce prothrombin.
Concomitant use with NSAIDs (with the exception of acetylsalicylic acid) increases the risk of seizures.
Metoclopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time to reach the maximum concentration of the latter.
Co-administration of uricosuric drugs slows down excretion (up to 50%) and increases the plasma concentration of ciprofloxacin.
When combined with other antimicrobials (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is usually observed. Therefore, ciprofloxacin can be successfully used in combination with azlocillin and ceftazidime for infections caused by Pseudomonas spp. with meslocillin, azlocillin and other beta-lactam antibiotics - for streptococcal infections with isoxazole penicillins and vancomycin - for staph infections with metronidazole and clindamycin - for anaerobic infections.
Ciprofloxacin enhances the nephrotoxic effect of cyclosporine, an increase in serum creatinine is also noted, therefore, in such patients, this indicator must be monitored 2 times a week.
With concomitant use, ciprofloxacin enhances the effect of indirect anticoagulants.
Pharmaceutical interaction
The infusion solution of the drug is pharmaceutically incompatible with all infusion solutions and preparations that are physically and chemically unstable under acidic conditions (the pH of the ciprofloxacin infusion solution is 3.5–4.6). You can not mix the solution for iv administration with solutions having a pH above 7.
Overdose
Treatment: The specific antidote is unknown. It is necessary to carefully monitor the condition of the patient, to do a gastric lavage, to carry out the usual emergency measures, to ensure sufficient fluid intake. With the help of hemo- or peritoneal dialysis, only a small (less than 10%) amount of the drug can be removed.
Storage conditions
Store in a dark place at 5 ° to 20 РC out of reach of children
active substance
Ciprofloxacin
lekarstvennaja form
Solution for infusion
Prescription
Adults prescribed by a doctor, Children prescribed by a doctor
Indications
Indications
From cystitis, From prostatitis, From intestinal infections, From urinary tract infections, From urinary tract infections , From sinusitis, From osteomyelitis, From skin infections, From bile duct infections, From pneumonia, From infectious diseases, From otitis media
Infusion solution.
Packing
bottle 100 ml zrdldp7777 100rd zrdrdp7777 bottle zrdrdp7777
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to ciprofloxacin: respiratory tract
ear, throat and nose
kidney and urinary tract
genital organs
digestive system (including mouth, teeth, jaws)
gall bladder and biliary tract
skin, mucous membranes and soft tissues
musculoskeletal system.
Ciprofloxacin is indicated for the treatment of sepsis and peritonitis, as well as for the prevention and treatment of infections in immunocompromised patients (with immunosuppressive therapy).
Contraindications
hypersensitivity to the drug ciprofloxacin
pseudo
glucose-6-phosphate dehydrogenase deficiency
fetal colitis
childhood up to 18 years of age (before the skeletal formation process increased srdl fluoroquinolone drugs.
With caution, the drug should be prescribed for severe cerebral arteriosclerosis, cerebrovascular accidents, mental illness, convulsive syndrome, epilepsy, severe renal and / or liver failure, elderly patients.
Use during pregnancy and lactation
Ciprofloxacin is contraindicated in pregnancy and lactation (breastfeeding).
Special instructions
If severe and prolonged diarrhea occurs during or after treatment with ciprofloxacin, the diagnosis of pseudomembranous colitis should be excluded, which requires immediate withdrawal of the drug and appropriate treatment.
During the treatment with ciprofloxacin, it is necessary to provide a sufficient amount of fluid while observing normal diuresis.
During treatment with ciprofloxacin, contact with direct sunlight should be avoided.
In patients with a history of seizures, a history of seizures, vascular diseases, and organic brain damage due to the risk of developing adverse reactions from the central nervous system, ciprofloxacin should be prescribed only for health reasons.
If severe and prolonged diarrhea occurs during or after treatment with ciprofloxacin, the diagnosis of pseudomembranous colitis should be excluded, which requires immediate withdrawal of the drug and the appointment of appropriate treatment.
If you experience pain in the tendons or when the first signs of tendovaginitis appear, treatment should be discontinued due to the fact that isolated cases of inflammation and even rupture of tendons during treatment with fluoroquinolones have been described.
Influence on the ability to drive vehicles and operate machinery
Patients taking Ciprofloxacin should be careful when driving a car and engaging in other potentially dangerous activities that require increased attention and speed of psychomotor reactions (especially while drinking alcohol).
Composition
Active ingredient: ciprofloxacin hydrochloride monohydrate (in terms of ciprofloxacin) - 2.0 mg.
Excipients: sodium chloride - 9.0 mg, disodium edetate dihydrate (disodium salt of ethylenediaminetetraacetic acid, Trilon B) - 0.10 mg, lactic acid (in terms of 100% substance) - 0.64 mg, water for injection - up to 1 ml.
Dosage and administration
The drug should be administered intravenously dropwise for 30 minutes (dose 200 mg) and 60 minutes (dose 400 mg).
The infusion solution can be combined with 0.9% sodium chloride solution, Ringer's solution, 5% and 10% dextrose (glucose) solution, 10% fructose solution, a solution containing 5% dextrose solution with 0.225% or 0.45% sodium chloride solution.
A single dose is 200 mg, with severe infections - 400 mg. The frequency of administration is 2 times / day, the duration of treatment is 1-2 weeks, if necessary, an increase in the course of treatment is possible.
In acute gonorrhea, the drug is administered intravenously once at a dose of 1000 mg.
For the prevention of postoperative infections - 30-60 minutes before surgery intravenously at a dose of 200-400 mg.
Patients with severe renal failure (CC must be prescribed half the daily dose.
Side effects
From the digestive system: nausea, diarrhea, vomiting, abdominal pain, flatulence, anorexia, cholestatic jaundice (especially in patients with past liver diseases), hepatitis, hepatonecrosis.
From the side of the central nervous system and peripheral nervous system: dizziness, headache, fatigue, anxiety, tremors, insomnia, nightmares, peripheral paralgesia (anomaly in the perception of pain), sweating, increased intracranial pressure, anxiety, confusion, depression, hallucinations manifestations of psychotic reactions (sometimes progressing to conditions in which the patient may harm himself), migraine, fainting, cerebral artery thrombosis.
On the part of the sensory organs: impaired taste and smell, impaired vision (diplopia, color perception), tinnitus, hearing loss.
From the cardiovascular system: tachycardia, cardiac arrhythmias, decreased blood pressure, flushing of the face.
From the hematopoietic system: leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.
On the part of laboratory parameters: hypoprothrombinemia, increased activity of hepatic transaminases and alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
From the urinary system: hematuria, crystalluria (primarily with alkaline urine and low diuresis), glomerulonephritis, dysuria, polyuria, urinary retention, albuminuria, urethral bleeding, hematuria, decreased kidney excretory function, interstitial nephritis.
From the musculoskeletal system: arthralgia, arthritis, tendovaginitis, tendon ruptures, myalgia.
Allergic reactions: skin itching, urticaria, the formation of blisters, accompanied by bleeding, scab-forming papules, drug fever, spot hemorrhages (petechiae), swelling of the face or larynx, shortness of breath, eosinophilia, increased photosensitivity, vasculitis, erythema nodosum, exudative erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis).
Other: arthralgia, arthritis, tendovaginitis, tendon ruptures, general weakness, myalgia, superinfection (candidiasis, pseudomembranous colitis), pain and burning sensation at the injection site, phlebitis.
Drug interaction
Due to the decrease in the activity of microsomal oxidation processes in hepatocytes, ciprofloxacin increases the concentration and lengthens the half-life of theophylline and other xanthines (e.g. caffeine), oral hypoglycemic drugs, indirect anticoagulants, and helps to reduce prothrombin.
Concomitant use with NSAIDs (with the exception of acetylsalicylic acid) increases the risk of seizures.
Metoclopramide accelerates the absorption of ciprofloxacin, which leads to a decrease in the time to reach the maximum concentration of the latter.
Co-administration of uricosuric drugs slows down excretion (up to 50%) and increases the plasma concentration of ciprofloxacin.
When combined with other antimicrobials (beta-lactam antibiotics, aminoglycosides, clindamycin, metronidazole), synergism is usually observed. Therefore, ciprofloxacin can be successfully used in combination with azlocillin and ceftazidime for infections caused by Pseudomonas spp. with meslocillin, azlocillin and other beta-lactam antibiotics - for streptococcal infections with isoxazole penicillins and vancomycin - for staph infections with metronidazole and clindamycin - for anaerobic infections.
Ciprofloxacin enhances the nephrotoxic effect of cyclosporine, an increase in serum creatinine is also noted, therefore, in such patients, this indicator must be monitored 2 times a week.
With concomitant use, ciprofloxacin enhances the effect of indirect anticoagulants.
Pharmaceutical interaction
The infusion solution of the drug is pharmaceutically incompatible with all infusion solutions and preparations that are physically and chemically unstable under acidic conditions (the pH of the ciprofloxacin infusion solution is 3.5–4.6). You can not mix the solution for iv administration with solutions having a pH above 7.
Overdose
Treatment: The specific antidote is unknown. It is necessary to carefully monitor the condition of the patient, to do a gastric lavage, to carry out the usual emergency measures, to ensure sufficient fluid intake. With the help of hemo- or peritoneal dialysis, only a small (less than 10%) amount of the drug can be removed.
Storage conditions
Store in a dark place at 5 ° to 20 РC out of reach of children
active substance
Ciprofloxacin
lekarstvennaja form
Solution for infusion
Prescription
Adults prescribed by a doctor, Children prescribed by a doctor
Indications
Indications
From cystitis, From prostatitis, From intestinal infections, From urinary tract infections, From urinary tract infections , From sinusitis, From osteomyelitis, From skin infections, From bile duct infections, From pneumonia, From infectious diseases, From otitis media
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