Chondroxide gel 5%, 30g

Ointment or gel should be applied 2-3 times / day to the skin over the lesion. Rub the ointment until completely absorbed for 2-3 minutes. The course of treatment with the ointment is 2-3 weeks. The gel is lightly rubbed in with patting movements for 2-3 minutes until completely absorbed. The course of gel treatment is from 2-3 weeks to 2-3 months. If necessary, repeat the course of treatment.

Gel for external use is yellowish, translucent, with a fruity odor.

1 g

chondroitin sodium sulfate 50 mg

Excipients: dimethyl sulfoxide (dimexide) - 100 mg, propylene glycol (1,2-propanediol) - 50 mg, isopropanol (isopropyl alcohol, 2-propanol) - 50 mg, ethanol (ethyl alcohol) - 200 mg, sodium disulfite (sodium metabisulfite ) - 0.5 mg, methyl parahydroxybenzoate (nipagin, methylparaben) - 1.2 mg, propyl parahydroxybenzoate (nipazole, propylparaben) - 0.3 mg, carbomer (carbopol) - 35 mg, orange flavoring (food flavoring 'Orange') - 5 mg, purified water - up to 1 g

• Damage to the skin in the area of ??application of the drug (for gel);

• hypersensitivity to the components of the drug.

  ChondroxideЃ should be used with caution in the dosage form, gel and ointment during pregnancy, lactation, in pediatric patients (efficacy and safety have not been established).

pharmachologic effect

Stimulator of tissue regeneration for external use. ChondroxideЃ has a combined effect: slows down the progression of osteoarthritis and osteochondrosis; has an analgesic effect; has anti-inflammatory effect; stimulates the restoration of articular cartilage; improves joint mobility; reduces joint swelling. Thanks to the optimal combination of the components of the gel, there is a mutual enhancement of their analgesic and anti-inflammatory effects. The use of the drug ChondroxideЃ allows you to reduce the dose of NSAIDs taken. ChondroxideЃ contains the natural component chondroitin sulfate (high molecular weight mucopolysaccharide), which is involved in the construction of cartilage tissue. Chondroitin sulfate improves calcium-phosphorus metabolism in cartilage tissue; reduces the activity of enzymes that destroy cartilage tissue;inhibits the processes of degeneration (destruction) of cartilage tissue; stimulates the synthesis of glycosaminoglycans; prevents the collapse of connective tissue. This leads to a decrease in soreness and an increase in the mobility of the affected joints.

Pharmacokinetics

ChondroxideЃ gel is well absorbed. In accordance with the data obtained in experimental studies on mice using radioactively labeled 3H-chondroitin sulfate, the absorption rate of chondroitin sulfate is 14%. Dimethyl sulfoxide promotes better penetration of chondroitin sulfate through cell membranes into tissues. Chondroitin sulfate after applying the drug Chondroxide gel to the skin quickly and selectively enters the joint with the achievement of Cmax after 30 minutes and subsequent two-phase elimination of the drug from the cartilage tissue. The completion of the rapid phase of elimination occurs 1 hour after application. The retention time of the drug in the joint is 5 hours.

Side effect

Possibly: allergic reactions. Application during pregnancy and lactation With caution and after consulting a doctor, ChondroxideЃ gel and ointment in dosage form should be used during pregnancy and lactation (breastfeeding).

Application in children

ChondroxideЃ should be used with caution in a dosage form of gel and ointment in pediatric patients (efficacy and safety have not been established).

special instructions

Avoid getting the drug on mucous membranes and open wounds. In contact with skin or clothing, the gel is easily washed off with water, leaving no residue. Use in pediatrics With caution and after consulting a doctor, the drug should be used in children (the effectiveness and safety of use in pediatrics have not been established).

Overdose

Currently, no cases of overdose of ChondroxideЃ have been reported. Drug interactions

Drug interactions

the drug ChondroxideЃ is not described.