Chondrolone lyophilisate for preparation of injection solution 100mg, No. 10

Degenerative diseases of the joints and spine:

• primary arthrosis,

• intervertebral osteochondrosis

In / m, after dissolving the lyophilisate in 1 ml of water for injection. 100 mg (1 ampoule) every other day; from the fourth injection, a single dose can be increased to 200 mg (2 ampoules). Course - 25-30 injections; repeated - after 6 months.

Lyophilisate for the preparation of a solution for intramuscular administration in the form of a white porous mass, compacted into a tablet, odorless.

1 amp.

chondroitin sulfate 100 mg

• Hypersensitivity

• bleeding tendency

• thrombophlebitis.

pharmachologic effect

Chondroitin sulfate is the main component of proteoglycans, which together with collagen fibers make up the cartilage matrix. Has chondroprotective properties; inhibits the activity of enzymes that cause degradation of articular cartilage; stimulates the production of proteoglycans by chondrocytes; enhances metabolic processes in cartilage and subchondral bone; participates in the construction of the basic substance of bone and cartilage tissue. It has an anti-inflammatory and analgesic effect, helps to reduce the release of inflammatory mediators and pain factors into the synovial fluid through synoviocytes and macrophages of the synovial membrane, suppresses the secretion of leukotriene B4 and prostaglandin E2.

The drug helps to restore the cartilaginous surfaces of the joints, prevents the collapse of the connective tissue; normalizes the production of articular fluid, which leads to an improvement in joint mobility, a decrease in the intensity of pain.

Pharmacokinetics

Chondrolone is easily absorbed by intramuscular injection. The maximum concentration is reached 1 hour after administration.

The drug accumulates in the synovial fluid. It is excreted from the body mainly by the kidneys within 24 hours.

Side effects

Allergic reactions, hemorrhages (at the injection site).

Application during pregnancy and lactation

Contraindicated in case of pregnancy and lactation.

Application in children

There is no experience of using the drug in children.

Drug interactions

Chondrolone can enhance the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics, which requires more frequent monitoring of blood coagulation indicators with the combined use of drugs.