Chloropyramine tablets 25mg, No. 20
Expiration Date: 05/2027
Russian Pharmacy name:
Хлоропирамин таблетки 25мг, №20
Allergic diseases, incl. urticaria, serum sickness, angioedema, hay fever (hay fever), allergic rhinopathies, allergic conjunctivitis.
Skin diseases, incl. contact dermatitis, acute and chronic eczema, drug rashes, itchy dermatoses.
Itching with insect bites.
The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
When taken orally for adults - 25 mg 3-4 times / day, for children, depending on age - 6.25-12.5 mg 2-3 times / day. The maximum dose for adults is 150 mg / day.
When administered intramuscularly or intravenously to adults, a single dose is 20-40 mg.
chloropyramine hydrochloride - 25 mg
Excipients : lactose monohydrate (milk sugar) - 130 mg, microcrystalline cellulose (type 12) - 32 mg, sodium carboxymethyl starch - 5 mg, povidone K30 - 6 mg, magnesium stearate - 2 mg.
Glaucoma (for parenteral administration),
benign prostatic hyperplasia,
urinary retention (for parenteral administration),
simultaneous administration of MAO inhibitors (for parenteral administration), gastric ulcer in the acute phase (for parenteral administration),
acute attack of bronchial asthma,
pregnancy,
lactation period,
early childhood up to 1 month,
hypersensitivity to chloropyramine or other ethylenediamine derivatives.
Clinical and pharmacological group: Histamine H1 receptor blocker. Antiallergic drug
Pharmaco-therapeutic group: H1-histamine receptor blocker
pharmachologic effect
A blocker of histamine H1 receptors, a derivative of ethylenediamine. It has anti-allergic and antipruritic effects. Causes sedation. Possesses peripheral anticholinergic activity, moderate antispasmodic properties.
Pharmacokinetics
After oral administration, chloropyramine hydrochloride is rapidly and completely absorbed from the gastrointestinal tract. Cmax in blood plasma is reached within the first 1-2 hours, the therapeutic level of concentration is maintained for 3-6 hours.
Regardless of the route of administration, it is well distributed in the body, including the central nervous system.
Plasma protein binding of chloropyramine is 7.9%. The binding peak is noted at pH 7.4.
It is metabolized in the liver.
It is introduced mainly by the kidneys in the form of metabolites. In children, elimination is faster than in adults.
Indications
Allergic diseases, incl. urticaria, serum sickness, angioedema, hay fever (hay fever), allergic rhinopathies, allergic conjunctivitis.
Skin diseases, incl. contact dermatitis, acute and chronic eczema, drug rashes, itchy dermatoses.
Itching with insect bites.
Dosage regimen
The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen.
When taken orally for adults - 25 mg 3-4 times / day, for children, depending on age - 6.25-12.5 mg 2-3 times / day. The maximum dose for adults is 150 mg / day.
When administered intramuscularly or intravenously to adults, a single dose is 20-40 mg.
Side effect
From the side of the central nervous system: lethargy, drowsiness, weakness, slight tremors, dizziness are possible. In children, some stimulating effect on the central nervous system is possible, manifested by anxiety, increased irritability, and insomnia.
From the digestive system: possible dry mouth, nausea, vomiting, diarrhea or constipation.
From the side of the cardiovascular system: rarely - lowering blood pressure (more often in elderly patients), tachycardia, arrhythmia.
Allergic reactions: possible skin rash, itching.
Others: rarely - difficulty urinating.
Contraindications for use
Glaucoma (for parenteral administration),
benign prostatic hyperplasia,
urinary retention (for parenteral administration),
simultaneous administration of MAO inhibitors (for parenteral administration), gastric ulcer in the acute phase (for parenteral administration),
acute attack of bronchial asthma,
pregnancy,
lactation period,
early childhood up to 1 month,
hypersensitivity to chloropyramine or other ethylenediamine derivatives.
Application during pregnancy and lactation
Contraindicated during pregnancy and lactation.
Application for violations of liver function
It should be used with caution in case of liver failure.
Application in children
Contraindicated in early childhood up to 1 month.
Use with caution in children due to the increased sensitivity of this category of patients to antihistamines.
Use in elderly patients
It should be used with caution in elderly patients.
special instructions
It should be used with caution in elderly patients, with liver failure and / or heart disease.
Use with caution in children due to the increased sensitivity of this category of patients to antihistamines.
With extreme caution, it should be used orally in patients with angle-closure glaucoma, urinary retention and prostatic hypertrophy.
When taken at night, chloropyramine may exacerbate the symptoms of reflux esophagitis.
During treatment, alcohol should be avoided.
Influence on the ability to drive vehicles and use mechanisms
In the initial, individually determined period of chloropyramine use, driving of vehicles and engaging in other potentially hazardous activities that require the speed of psychomotor reactions are not allowed. In the course of further treatment, the degree of restrictions is determined depending on the tolerance of the treatment.
Drug interactions
With the simultaneous use of chloropyramine potentiates the effects of anesthetics, hypnotics, tranquilizers, analgesics, MAO inhibitors, tricyclic antidepressants, atropine and sympatholytics (this combination requires caution).
With the simultaneous use of chloropyramine and caffeine or phenamine, there is a decrease or elimination of the inhibitory effect of chloropyramine on the central nervous system.