Cetirizine | Cetrin tablets coated film 10 mg 20 pcs.
Special Price
$16.49
Regular Price
$24.00
In stock
SKU
BID494240
Description
Round biconvex tablets coated with a film membrane of white or almost white color, with a risk on one side.
On a cross-section, the core is white to almost white.
Round biconvex tablets coated with a film membrane of white or almost white color, with a risk on one side.
On a cross-section, the core is white to almost white.
Description
Round biconvex tablets coated with a film membrane of white or almost white color, with a risk on one side.
On a cross-section, the core is white to almost white.
Release form
film-coated tablets.
packaging 20 pcs
Pharmacological action
Pharmacodynamics
A competitive histamine antagonist, a metabolite of hydroxyzine, blocks H1-histamine receptors. It prevents the development and facilitates the course of allergic reactions, has an antipruritic and antiexudative effect. It affects the early stage of allergic reactions, limits the release of inflammatory mediators in the "late" stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles.
Eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction in mild asthma.
Virtually no anticholinergic and antiserotonin effects.
In therapeutic doses, it practically does not cause a sedative effect. The onset of the effect after a single dose of 10 mg of cetirizine is 20 minutes, lasts more than 24 hours. Against the background of the course of treatment, tolerance to the antihistamine action of cetirizine does not develop. After discontinuation of treatment, the effect lasts up to 3 days.
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract, the time to reach maximum concentration (TCmax) after ingestion is about 1 hour. Food does not affect absorption (AUC), but prolongs TCmax by 1 hour and reduces the maximum concentration (Cmax) by 23%. When taken at a dose of 10 mg once a day for 10 days, the equilibrium concentration of the drug (Css) in plasma is 310 ng / ml and is observed 0.5-1.5 hours after administration. Communication with plasma proteins is 93% and does not change at a concentration of cetirizine in the range of 25–1000 ng / ml. The pharmacokinetic parameters of cetirizine change linearly when administered at a dose of 5-60 mg. Distribution volume - 0.5 l / kg.
Metabolized in small amounts in the liver by O-dealkylation to form a pharmacologically inactive metabolite (unlike other blockers of H1-histamine receptors metabolized in the liver by the cytochrome P450 system). Cetirizine is not cumulated. About 2/3 of the drug is excreted unchanged by the kidneys and about 10% - with feces.
Systemic clearance - 53 ml / min. The half-life (T1 / 2) in adults is 10 hours, in children 6-12 years old - 6 hours, 2-6 years - 5 hours, 0.5-2 years - 3.1 hours. In elderly patients, T1 / 2 increases by 50%, systemic clearance is reduced by 40% (decreased renal function).
In patients with impaired renal function (creatinine clearance below 40 ml / min), the clearance of the drug decreases, and T1 / 2 lengthens (for example, in patients on hemodialysis, the total clearance decreases by 70% and is 0, 3 ml / min / kg, and T1 / 2 lengthens 3 times), which requires a corresponding change in the dosage regimen. Almost not removed during hemodialysis.
In patients with chronic liver diseases (hepatocellular, cholestatic, or biliary cirrhosis), a T1 / 2 elongation of 50% and a decrease in overall clearance by 40% are observed (correction of the dosage regimen is required only with a concomitant decrease in glomerular filtration rate). Penetrates into breast milk.
Indications
Seasonal and perennial allergic rhinitis
allergic conjunctivitis
pollinosis (hay fever)
urticaria, including chronic idiopathic urticaria
pruritic neurodermatitis dermatitis dermatitis dermatitis dermatitis
Contraindications
Hypersensitivity (including to hydroxyzine)
breastfeeding period for children under 6 years of age (for this dosage form).
Precautions:
Chronic renal failure (moderate and severe - requires dosage adjustment), old age (possibly reduced glomerular filtration).
Use during pregnancy and lactation
Pregnancy
When analyzing prospective data on pregnancy outcomes, there were no cases of the formation of malformations, fetal and neonatal toxicity with a clear causal relationship.
Animal studies have not revealed any direct or indirect adverse effects of cetirizine on the developing fetus (including in the postnatal period), during pregnancy and childbirth.
There have been no controlled clinical trials on the safety of the drug during pregnancy, so cetirizine should not be used during pregnancy.
Breastfeeding
Cetirizine is excreted in breast milk in a concentration representing 25% to 90% of the plasma concentration of the drug, depending on the time of administration. During breastfeeding, the drug is used after consulting a doctor if the expected benefit to the mother outweighs the potential risk to the baby.
Fertility
Available data on the effects on human fertility are limited, however, no adverse effects on fertility have been identified.
Special instructions
If you exceed a dose of 10 mg / day, your ability to react quickly may worsen.
At recommended doses, it does not enhance the action of ethanol (at a concentration of not more than 0.8 g / l), however, it is recommended to refrain from using it during treatment.
For children (from 2 years old) Cetrin® is used in the form of a syrup.
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Composition
Each tablet, film coating comprises:
Active substance:
cetirizine dihydrochloride 10 mg
Excipients:
Lactose
Starch Corn
Povidone (K-30)
Magnesium stearate
film coated:
Hypromellose
Macrogol 6000
Titanium Dioxide
Talc
Sorbic acid
Polysorbate 80
Dimethicone
Dosage and administration
Inside, regardless of the meal, without chewing, the tablets are washed down with 200 ml of water.
Adults - 10 mg (1 tab.) 1 time per day or 5 mg (1/2 tab.) 2 times a day.
Children over 6 years of age - 5 mg (1/2 tab.) 2 times a day or 10 mg (1 tab.) 1 time per day.
In patients with reduced renal function (creatinine clearance 30–49 ml / min), 5 mg / day (1/2 tab.) is prescribed, in severe chronic renal failure (creatinine clearance 10–30 ml / min) - 5 mg / day (1/2 tab.) Every other day.
Side effects
Usually Cetrin® is well tolerated.
In some cases, it is possible: drowsiness, dry mouth rarely - headache, dizziness, migraine, discomfort in the gastrointestinal tract (dyspepsia, abdominal pain, flatulence), allergic reactions (angioneurotic edema, rash, hives).
Drug Interaction
There is no data on the interaction of cetirizine with other medicines so far, however, caution should be exercised when administering the drug with sedatives.
Overdose of
Symptoms:
drowsiness with a significant overdose of the drug (30-40 times the therapeutic dose in adults and children) - drowsiness, anxiety, itching, rash, urinary retention, fatigue, tremor, tachycardia.
In all cases, a complete normalization of the state was observed.
Treatment:
gastric lavage if necessary - symptomatic therapy.
There is no specific antidote.
Hemodialysis is ineffective.
Storage Conditions
At a temperature not exceeding 25 РC.
Keep out of the reach and sight of children!
Expiration
2 years.
active substance
Cetirizine
Pharmacy terms
Pharmacy terms
Non prescription
Round biconvex tablets coated with a film membrane of white or almost white color, with a risk on one side.
On a cross-section, the core is white to almost white.
Release form
film-coated tablets.
packaging 20 pcs
Pharmacological action
Pharmacodynamics
A competitive histamine antagonist, a metabolite of hydroxyzine, blocks H1-histamine receptors. It prevents the development and facilitates the course of allergic reactions, has an antipruritic and antiexudative effect. It affects the early stage of allergic reactions, limits the release of inflammatory mediators in the "late" stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils. Reduces capillary permeability, prevents the development of tissue edema, relieves spasm of smooth muscles.
Eliminates the skin reaction to the introduction of histamine, specific allergens, as well as cooling (with cold urticaria). Reduces histamine-induced bronchoconstriction in mild asthma.
Virtually no anticholinergic and antiserotonin effects.
In therapeutic doses, it practically does not cause a sedative effect. The onset of the effect after a single dose of 10 mg of cetirizine is 20 minutes, lasts more than 24 hours. Against the background of the course of treatment, tolerance to the antihistamine action of cetirizine does not develop. After discontinuation of treatment, the effect lasts up to 3 days.
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract, the time to reach maximum concentration (TCmax) after ingestion is about 1 hour. Food does not affect absorption (AUC), but prolongs TCmax by 1 hour and reduces the maximum concentration (Cmax) by 23%. When taken at a dose of 10 mg once a day for 10 days, the equilibrium concentration of the drug (Css) in plasma is 310 ng / ml and is observed 0.5-1.5 hours after administration. Communication with plasma proteins is 93% and does not change at a concentration of cetirizine in the range of 25–1000 ng / ml. The pharmacokinetic parameters of cetirizine change linearly when administered at a dose of 5-60 mg. Distribution volume - 0.5 l / kg.
Metabolized in small amounts in the liver by O-dealkylation to form a pharmacologically inactive metabolite (unlike other blockers of H1-histamine receptors metabolized in the liver by the cytochrome P450 system). Cetirizine is not cumulated. About 2/3 of the drug is excreted unchanged by the kidneys and about 10% - with feces.
Systemic clearance - 53 ml / min. The half-life (T1 / 2) in adults is 10 hours, in children 6-12 years old - 6 hours, 2-6 years - 5 hours, 0.5-2 years - 3.1 hours. In elderly patients, T1 / 2 increases by 50%, systemic clearance is reduced by 40% (decreased renal function).
In patients with impaired renal function (creatinine clearance below 40 ml / min), the clearance of the drug decreases, and T1 / 2 lengthens (for example, in patients on hemodialysis, the total clearance decreases by 70% and is 0, 3 ml / min / kg, and T1 / 2 lengthens 3 times), which requires a corresponding change in the dosage regimen. Almost not removed during hemodialysis.
In patients with chronic liver diseases (hepatocellular, cholestatic, or biliary cirrhosis), a T1 / 2 elongation of 50% and a decrease in overall clearance by 40% are observed (correction of the dosage regimen is required only with a concomitant decrease in glomerular filtration rate). Penetrates into breast milk.
Indications
Seasonal and perennial allergic rhinitis
allergic conjunctivitis
pollinosis (hay fever)
urticaria, including chronic idiopathic urticaria
pruritic neurodermatitis dermatitis dermatitis dermatitis dermatitis
Contraindications
Hypersensitivity (including to hydroxyzine)
breastfeeding period for children under 6 years of age (for this dosage form).
Precautions:
Chronic renal failure (moderate and severe - requires dosage adjustment), old age (possibly reduced glomerular filtration).
Use during pregnancy and lactation
Pregnancy
When analyzing prospective data on pregnancy outcomes, there were no cases of the formation of malformations, fetal and neonatal toxicity with a clear causal relationship.
Animal studies have not revealed any direct or indirect adverse effects of cetirizine on the developing fetus (including in the postnatal period), during pregnancy and childbirth.
There have been no controlled clinical trials on the safety of the drug during pregnancy, so cetirizine should not be used during pregnancy.
Breastfeeding
Cetirizine is excreted in breast milk in a concentration representing 25% to 90% of the plasma concentration of the drug, depending on the time of administration. During breastfeeding, the drug is used after consulting a doctor if the expected benefit to the mother outweighs the potential risk to the baby.
Fertility
Available data on the effects on human fertility are limited, however, no adverse effects on fertility have been identified.
Special instructions
If you exceed a dose of 10 mg / day, your ability to react quickly may worsen.
At recommended doses, it does not enhance the action of ethanol (at a concentration of not more than 0.8 g / l), however, it is recommended to refrain from using it during treatment.
For children (from 2 years old) Cetrin® is used in the form of a syrup.
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Composition
Each tablet, film coating comprises:
Active substance:
cetirizine dihydrochloride 10 mg
Excipients:
Lactose
Starch Corn
Povidone (K-30)
Magnesium stearate
film coated:
Hypromellose
Macrogol 6000
Titanium Dioxide
Talc
Sorbic acid
Polysorbate 80
Dimethicone
Dosage and administration
Inside, regardless of the meal, without chewing, the tablets are washed down with 200 ml of water.
Adults - 10 mg (1 tab.) 1 time per day or 5 mg (1/2 tab.) 2 times a day.
Children over 6 years of age - 5 mg (1/2 tab.) 2 times a day or 10 mg (1 tab.) 1 time per day.
In patients with reduced renal function (creatinine clearance 30–49 ml / min), 5 mg / day (1/2 tab.) is prescribed, in severe chronic renal failure (creatinine clearance 10–30 ml / min) - 5 mg / day (1/2 tab.) Every other day.
Side effects
Usually Cetrin® is well tolerated.
In some cases, it is possible: drowsiness, dry mouth rarely - headache, dizziness, migraine, discomfort in the gastrointestinal tract (dyspepsia, abdominal pain, flatulence), allergic reactions (angioneurotic edema, rash, hives).
Drug Interaction
There is no data on the interaction of cetirizine with other medicines so far, however, caution should be exercised when administering the drug with sedatives.
Overdose of
Symptoms:
drowsiness with a significant overdose of the drug (30-40 times the therapeutic dose in adults and children) - drowsiness, anxiety, itching, rash, urinary retention, fatigue, tremor, tachycardia.
In all cases, a complete normalization of the state was observed.
Treatment:
gastric lavage if necessary - symptomatic therapy.
There is no specific antidote.
Hemodialysis is ineffective.
Storage Conditions
At a temperature not exceeding 25 РC.
Keep out of the reach and sight of children!
Expiration
2 years.
active substance
Cetirizine
Pharmacy terms
Pharmacy terms
Non prescription
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