Ceraxon solution 1000mg / 4ml, No. 5
Expiration Date: 05/2027
Russian Pharmacy name:
Цераксон раствор 1000мг/4мл, №5
acute period of ischemic stroke (as part of complex therapy);
the recovery period of ischemic and hemorrhagic strokes;
TBI, acute (as part of complex therapy) and recovery period;
cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Solution for i / v, i / m administration.
Intravenous, in the form of a slow intravenous injection (within 3-5 minutes, depending on the prescribed dose) or drip intravenous infusion (40-60 drops per minute).
The intravenous route of administration is preferable to the intramuscular route. With intramuscular administration, repeated administration of the drug in the same place should be avoided.
Recommended dosage regimen
Acute period of ischemic stroke and TBI: 1000 mg every 12 hours from the first day after diagnosis, the duration of treatment is at least 6 weeks. 3-5 days after the start of treatment (if the swallowing function is not impaired), it is possible to switch to oral forms of the drug CeraxonЃ.
The recovery period of ischemic and hemorrhagic strokes, the recovery period of TBI, cognitive and behavioral disorders in degenerative and vascular diseases of the brain: 500-2000 mg per day. Dosage and duration of treatment - depending on the severity of the symptoms of the disease. It is possible to use oral forms of the drug CeraxonЃ.
Elderly patients
When prescribing CeraxonЃ to elderly patients, dose adjustment is not required.
Solution in ampoule is intended for single use. It must be used immediately after opening the ampoule.
The drug is compatible with all types of intravenous isotonic solutions and dextrose solutions.
Oral solution.
Before use, the drug can be diluted in a small amount of water (120 ml or 1/2 cup). It is taken with meals or between meals.
Recommended dosage regimen
Acute period of ischemic stroke and TBI: 1000 mg (10 ml or 1 pack.) Every 12 hours. Duration of treatment is at least 6 weeks.
The recovery period of ischemic and hemorrhagic strokes, the recovery period of TBI, cognitive and behavioral disorders in degenerative and vascular diseases of the brain: 500-2000 mg per day (5-10 ml or 1 pack. (1000 mg) 1-2 times a day). Dosage and duration of treatment - depending on the severity of the symptoms of the disease.
Elderly patients
When prescribing CeraxonЃ to elderly patients, dose adjustment is not required.
Instructions for using the dosing syringe (Fig. 1):
Picture 1.
1. Place the dosing syringe into the vial (the syringe plunger is fully lowered) (Fig. 1 (1).
2. Gently pull on the plunger of the dosing syringe until the solution level is level with the corresponding mark on the syringe (Fig. 1 (2).
3. Before use, the required amount of solution can be diluted in 1/2 glass of water (120 ml) (Fig. 1 (3).
After each use, it is recommended to rinse the dosing syringe with water.
Recommendations for the use of the drug CeraxonЃ in sachets:
1. Separate one bag from another along the tear-off seam. Holding the bag vertically, carefully tear off its edge at the УOpen hereФ mark (Fig. 2).
Figure 2.
2. The contents of the sachet can be drunk immediately after opening (Fig. 3) or before taking it can be diluted in 1/2 glass of water (120 ml) (Fig. 4).
Figure 3.
Figure 4.
| Solution for intravenous and intramuscular administration | 4 ml |
| active substance: | |
| citicoline sodium | 522.5 mg |
| (equivalent to 500 mg citicoline) | |
| citicoline sodium | 1045 mg |
| (equivalent to 1000 mg citicoline) | |
| auxiliary substances: 1M hydrochloric acid or 1M sodium hydroxide - up to pH 6.7-7.1; water for injection - up to 4 ml |
| Oral solution | 1 ml |
| active substance: | |
| citicoline sodium | 104.5 mg |
| (equivalent to 100 mg citicoline) | |
| excipients: sorbitol - 200 mg; glycerol - 50 mg; methyl parahydroxybenzoate - 1.45 mg; propyl parahydroxybenzoate - 0.25 mg; sodium citrate dihydrate - 6 mg; sodium saccharinate - 0.2 mg; strawberry flavor (strawberry essence 1487-S-Lucta) - 0.408 mg; potassium sorbate - 3 mg; citric acid 50% solution - up to pH 6; purified water - up to 1 ml |
| Oral solution | 1 pack. (10 ml) |
| active substance: | |
| citicoline sodium | 1045 mg |
| (equivalent to 1000 mg citicoline) | |
| excipients: sorbitol - 2000 mg; glycerol - 500 mg; methyl parahydroxybenzoate - 14.5 mg; propyl parahydroxybenzoate - 2.5 mg; sodium citrate dihydrate - 60 mg; sodium saccharinate - 2 mg; strawberry flavor (strawberry essence 1487-S-Lucta) - 4.08 mg; potassium sorbate - 30 mg; citric acid 50% solution - up to pH 6; purified water - up to 10 ml |
hypersensitivity to any component of the drug;
severe vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system);
rare hereditary diseases associated with fructose intolerance;
children under 18 years of age (due to the lack of sufficient clinical data).
Pharmacological action
Ceraxon is a nootropic drug.
Citicoline, being a precursor of key ultrastructural components of the cell membrane (mainly phospholipids), has a wide spectrum of action: it promotes the restoration of damaged cell membranes, inhibits the action of phospholipases, preventing the excessive formation of free radicals, and also prevents cell death by affecting the mechanisms of apoptosis.
In the acute period of stroke, citicoline reduces the amount of damage to the brain tissue, improves cholinergic transmission.
In traumatic brain injury, it reduces the duration of post-traumatic coma and the severity of neurological symptoms, in addition, citicoline helps to reduce the duration of the recovery period.
Indications
-Acute period of ischemic stroke (as part of complex therapy);
- the recovery period of ischemic and hemorrhagic strokes;
- TBI, acute (as part of complex therapy) and recovery period;
- cognitive and behavioral disorders in degenerative and vascular diseases of the brain.
Contraindications -
hypersensitivity to any component of the drug;
- Severe vagotonia (predominance of the tone of the parasympathetic part of the autonomic nervous system);
- rare hereditary diseases associated with fructose intolerance;
- children under 18 years of age (due to the lack of sufficient clinical data).
Method of administration and dosage
The drug is taken with meals or between meals. Before use, the drug can be diluted in a small amount of water (120 ml or 1/2 cup).
Acute period of ischemic stroke and traumatic brain injury: the recommended dose is 1000 mg (10 ml) every 12 hours. The duration of treatment is at least 6 weeks.
The dose and duration of treatment depend on the severity of the symptoms of the disease.
Side effects
Allergic reactions (rash, pruritus, anaphylactic shock), headache, dizziness, fever, tremors, nausea, vomiting, diarrhea, hallucinations, edema, shortness of breath, insomnia, agitation, decreased appetite, numbness in paralyzed limbs, changes in the activity of liver enzymes ... In some cases, CeraxonЃ can stimulate the parasympathetic system, as well as cause a short-term change in blood pressure.
Overdose
Given the low toxicity of the drug, overdose cases have not been described.