Ceftiosan 100ml

DESCRIPTION

Ceftiosan is an antibiotic from the cephalosporin group for the treatment of bacterial infections in cattle and pigs. In appearance, the drug is a sterile suspension from white to light yellow for injection, during storage of which a precipitate may form, which disappears upon shaking.

COMPOSITION

As an active ingredient in 1 ml contains 50 mg of ceftiofur hydrochloride, and as auxiliary components: aluminum monostearate, sorbitan monoleate and medium chain triglycerides (MCTs).

PHARMACOLOGICAL PROPERTIES

The active ingredient of the drug is ceftiofur hydrochloride, a third-generation cephalosporin antibiotic with a wide spectrum of bactericidal action against gram-negative and gram-positive bacteria, including strains producing ОІ-lactamase and some anaerobic bacteria, namely: Streptococcus spp., Actynomyces pycogenes, sappp. Salmonella choleraesuis, Escherichia coli, Pasteurella haemolytica, Pasteurella multocida, Haemophilus spp., Actinobacillus pleuropneumoniae, Klebsiella spp., Citrobacter spp., Enterobacter spp., Bacillus spp., Proteobacter spp., Bacillus spp., Proteobacter spp., Fus melinus melophinus. The mechanism of action of ceftiofur hydrochloride is to inhibit the synthesis of the bacterial cell wall. After parenteral administration, ceftiofur hydrochloride is rapidly metabolized to form desfuroylceftiofur, which has an activity equivalent to ceftiofur hydrochloride against bacteria. The active metabolite binds reversibly to plasma proteins and concentrates in the tissues affected by the pathogen. After intramuscular administration of Ceftiosan to pigs, the maximum concentration of ceftiofur hydrochloride and its metabolites in the blood serum is reached after 0.5 - 2 hours and is maintained at a therapeutic level for up to 24 hours from the moment of drug administration. Intramuscular bioavailability is close to 100%. After subcutaneous administration of Ceftiosan to cattle, the maximum concentration of the antibiotic in the plasma is recorded after 2 hours, in the endometrium after 4 to 6 hours. The drug and its metabolites are excreted from the body of animals mainly with urine (over 70%) and feces (about 30%). According to the degree of impact on the body of warm-blooded animals, Ceftiosan is classified as a low-hazard substance.

INDICATIONS

Assign to cattle and pigs with a therapeutic purpose for respiratory diseases, interdigital necrobacteriosis, acute postpartum metritis and other primary and secondary infections of bacterial etiology, the causative agents of which are sensitive to ceftiofur hydrochloride.

DOSAGE AND APPLICATION

Ceftiosan is administered to animals once a day in doses: large horned 1 ml per 50 kg of body weight subcutaneously (or 1 mg of ceftiofur hydrochloride per 1 kg of body weight according to the active ingredient) for 3 to 5 days for respiratory diseases, for 3 days with necrobacteriosis and 5 days with endometritis; pigs, 1 ml per 16 kg of body weight intramuscularly (or 3 mg of ceftiofur per 1 kg of body weight according to the active ingredient) for respiratory diseases within 3 days. If you miss one injection, you must enter it as soon as possible, then the interval between drug injections does not change. Shake the vial with the drug thoroughly before each use.

SPECIAL INSTRUCTIONS

Slaughter of cattle for meat is allowed no earlier than 8 days, pigs - no earlier than 6 days after the last administration of Ceftiosan. The meat of animals that were forcedly killed before the expiration of the specified time limits can be used as feed for fur animals. Milk of dairy cows during the period of application of the drug is used for food purposes without restrictions. During the manipulation of the medicinal product, it is not allowed to smoke, drink and eat. After finishing work, wash your hands with warm water and soap. In case of accidental contact of the drug on the skin or mucous membranes of the eyes, they must be rinsed with plenty of running water. People with allergies should avoid direct contact with the drug.

CONTRAINDICATIONS

Increased individual sensitivity of the animal to ОІ-lactam antibiotics. Ceftiosan should not be administered in conjunction with tetracyclines, chloramphenicol, macrolides and lincosamides, as well as mixed with other drugs in the same syringe.

SIDE EFFECTS

With increased individual sensitivity to the drug in animals, allergic reactions are possible. In these cases, the drug is discontinued and antihistamines and symptomatic treatment are prescribed. The animal may experience a decrease in appetite and an inflammatory reaction at the injection site in the form of edema, which spontaneously disappears within 1 to 2 days and does not require treatment.

SHELF LIFE AND STORAGE

Store in a dry, dark place and out of reach of children and animals, separately from food and feed in closed manufacturer's packaging at temperatures from 5 to 25 В° C. Shelf life is 2 years. Opened vials with the drug can be stored for no more than 28 days.

PACKAGING

Ceftiosan is produced packaged in 100 ml glass bottles packed in cardboard boxes.

Specifications

KolVUP

ten

Manufacturer

APICENNA

Temperature regime

from +5 to +25

Teaser

for the treatment of respiratory diseases, interdigital necrobacteriosis, acute postpartum metritis and other primary and secondary infections of bacterial etiology, the causative agents of which are sensitive to ceftiofur hydrochloride