Cefecon D suppositories 100mg, No. 10
Expiration Date: 05/2027
Russian Pharmacy name:
Цефекон Д суппозитории 100мг, №10
Used in children from 3 months to 12 years as:
antipyretic agent for acute respiratory infections, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by an increase in body temperature;
pain reliever for pain syndrome of mild and moderate intensity, incl. headache and toothache, muscle pain, neuralgia, pain in trauma and burns.
In children from 1 to 3 months, a single dose of the drug is possible to lower the temperature after vaccination.
Rectally, after a cleansing enema or spontaneous bowel movement. The dosage of the drug is calculated depending on the age and body weight, in accordance with the table. A single dose is 10-15 mg / kg 2-3 times a day after 4-6 hours. The maximum daily dose of paracetamol should not exceed 60 mg / kg.
Table
Dosage of the drug for children of different ages
| Age | Weight, kg | Single dose |
| 1-3 months | 4-6 | 1 supp. 0.05 g (50 mg) |
| 3-12 months | 7-10 | 1 supp. 0.1 g (100 mg) |
| 1-3 years | 11-16 | 1-2 supp. 0.1 g (100 mg) |
| 3-10 years | 17-30 | 1 supp. 0.25 g (250 mg) |
| 10-12 years old | 31-35 | 2 supp. 0.25 g (250 mg) |
| Rectal suppositories for children | 1 supp. |
| paracetamol | 0.05 g |
| 0.1 g | |
| 0.25 g | |
| excipients: witepsol - a sufficient amount to obtain a suppository weighing from 1.25 g |
in a contour acheikova package 5 pcs .; in a pack of cardboard 2 packages.
-Hypersensitivity to the components of the drug;
- age up to 1 month of life.
Carefully:
dysfunction of the liver and kidneys;
Gilbert's syndrome; Dubin-Johnson and Rotor;
diseases of the blood system (anemia, thrombocytopenia, leukopenia);
genetic absence of the enzyme glucose-6-phosphate dehydrogenase.
pharmachologic effect
It has an analgesic and antipyretic effect. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. In the focus of inflammation, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the absence of a significant anti-inflammatory effect. The drug has no negative effect on water-electrolyte metabolism (does not lead to sodium and water retention) and the gastrointestinal mucosa.
Pharmacokinetics
Absorption and distribution Rapidly and highly absorbed from the gastrointestinal tract. Cmax is reached after 30-60 minutes. Plasma protein binding - 15%. Penetrates the BBB. Metabolism and excretion Metabolized in the liver; 80% reacts with glucuronic acid and sulfates to form inactive metabolites; 17% undergoes hydroxylation to form active metabolites, which are then conjugated with glutathione to form inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis. T1 / 2 - 2-3 hours. Within 24 hours 85-95% of paracetamol is excreted by the kidneys in the form of glucuronides and sulfates, unchanged - 3%. Pharmacokinetics in special clinical cases Vd and bioavailability in children (including newborns) are similar to those in adults.In newborns of the first 2 days of life and in children aged 3-10 years, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years and older - conjugated glucuronide. There is no significant age-related difference in the rate of elimination of paracetamol and in the total amount of the drug excreted in the urine.
Side effect
From the digestive system: possible nausea, vomiting, abdominal pain. Allergic reactions: rash on the skin and mucous membranes, itching, urticaria, Quincke's edema. From the hematopoietic system: rarely - anemia, thrombocytopenia, leukopenia, agranulocytosis. With prolonged use in high doses, it is possible to develop hepatotoxic and nephrotoxic (interstitial nephritis and papillary necrosis) action, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.
Application for violations of liver function
The drug is used with caution in case of liver dysfunction.
Application for impaired renal function
The drug is used with caution in case of impaired renal function.
special instructions
The patient should be warned about the need to see a doctor if the fever continues for more than 3 days and the pain syndrome continues for more than 5 days. Simultaneous use with other paracetamol-containing drugs should be avoided, because it can cause paracetamol overdose. When using the drug for more than 5-7 days, the peripheral blood parameters and the functional state of the liver should be monitored. Paracetamol distorts laboratory tests in the quantitative determination of glucose and uric acid in plasma.
Overdose
Data on overdose of the drug Cefekon D are not provided.
Drug interactions
Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol, hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose. Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects. When taken simultaneously with salicylates, the likelihood of developing a nephrotoxic effect increases. When combined with paracetamol, the toxic effects of chloramphenicol are enhanced. When combined with paracetamol, the effect of indirect anticoagulants increases and the effectiveness of uricosuric drugs decreases.