Carsil et al. 35mg # 80

Release form, composition and packaging

Dragee coated with a brown outer layer and a white inner layer, biconvex

at the break - from brownish-yellow to light brown.

1 tablet

dry extract of milk thistle fruit (silymarin equivalent)

35 mg

lactose monohydrate - 55.38 mg, wheat starch - 55.38 mg, povidone (colidone 25) - 1.65 mg, microcrystalline cellulose - 67 mg, magnesium stearate - 2.5 mg, talc - 7 mg, dextrose monohydrate - 20.6 mg, sorbitol - 4.13 mg, sodium bicarbonate - 1.36 mg.

Shell composition: cellacephate - 0.84 mg, diethyl phthalate - 0.6 mg, sucrose - 162.19 mg, acacia gum - 1.562 mg, gelatin - 0.86 mg, talc - 26.718 mg, titanium dioxide - 4.82 mg, macrogol (PEG 6000) - 0.13 mg, dye Brown Opalux (sucrose, red iron oxide, black iron oxide, methyl and propyl parahydroxybenzoate, purified water) - 2.25 mg, glycerol - 0.03 mg.

10 pieces.

- blisters (8) - cardboard packs.

10 pieces. - blisters (18) - packs of cardboard. Pharmacological action Plant-derived product. The main one is the hepatoprotective effect. Flavolignans, incl. silybin, dehydrosilybin, isosilybin, silymarin, dehydrosilymarin, silychristin, tasifolin (2.8-3.8%) stabilize lysosomal and cell membranes, preventing the release of enzymes from cells. They interact with free radicals and inhibit lipid peroxidation processes. Due to the antioxidant effect, they inhibit the penetration of various toxins into the liver cells (including chlorinated hydrocarbons, alpha-amanitin of the pale toadstool, nitrosoamines). Silybin, silymarin and their derivatives stimulate specific RNA polymerase A, as a result of which the synthesis of proteins and phospholipids in hepatocytes is activated, the processes of regeneration and detoxification in the liver are accelerated.

The normalization of metabolic processes is promoted by tocopherols, macro- (potassium, magnesium) and microelements (copper, selenium) contained in fruits. Fatty oil of fruits (20-34%) contains a large amount of unsaturated fatty acids (including linoleic acid - 50-62%), which have redox properties, promote cholesterol oxidation and, together with beta-sitosterol, prevent atherosclerosis. The mucus polysaccharides (5%) have an enveloping and gastroprotective effect. Betaine, a nitrogen-containing compound, improves digestion and bile formation in the liver. Milk thistle fruits have a lactogenic effect. '' Indications for use Condition after hepatitis of viral and toxic etiology, liver injury, operations on the abdominal organs chronic hepatitis, hepatocholecystitis, biliary dyskinesia,pancreatitis, liver cirrhosis toxic liver damage (including those caused by the use of aminoglycosides, tetracycline, immunosuppressants, NSAIDs, anti-tuberculosis drugs, barbiturates, tranquilizers organic solvents poisoning with mushrooms, heavy metal salts, halogenated hydrocarbons with alcohol intoxication) hyperlipidemia, prevention of atherosclerosis. Contraindications for use Hypersensitivity to milk thistle. Dosing regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used.due to the use of aminoglycosides, tetracycline, immunosuppressants, NSAIDs, anti-tuberculosis drugs, barbiturates, tranquilizers organic solvents poisoning by mushrooms, heavy metal salts, halogenated hydrocarbons with alcohol intoxication) hyperlipidemia, prevention of atherosclerosis. Contraindications for use Hypersensitivity to milk thistle. Dosing regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used. Side effect Rarely: laxative effect. Special instructions There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.due to the use of aminoglycosides, tetracycline, immunosuppressants, NSAIDs, anti-tuberculosis drugs, barbiturates, tranquilizers organic solvents poisoning by mushrooms, heavy metal salts, halogenated hydrocarbons with alcohol intoxication) hyperlipidemia, prevention of atherosclerosis. Contraindications for use Hypersensitivity to milk thistle. Dosing regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used. Side effect Rarely: a laxative effect. Special instructions There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.organic solvents poisoning by mushrooms, heavy metal salts, halogenated hydrocarbons with alcohol intoxication) hyperlipidemia, prevention of atherosclerosis. Contraindications for use Hypersensitivity to milk thistle. Dosing regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used. Side effect Rarely: laxative effect. Special instructions There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.organic solvents poisoning by mushrooms, heavy metal salts, halogenated hydrocarbons with alcohol intoxication) hyperlipidemia, prevention of atherosclerosis. Contraindications for use Hypersensitivity to milk thistle. Dosing regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used. Side effect Rarely: laxative effect. Special instructions There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.Dosage regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used. Side effect Rarely: laxative effect. Special instructions There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.Dosage regimen The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used. Side effect Rarely: a laxative effect. Special instructions There is a message about the antagonistic interaction of silymarin with yohimbine and phentolamine.

Name ENG

CARSIL

Clinical and pharmacological group

Hepatoprotector

ATX code

Silymarin

Dosage

35mg

Structure

1 tablet contains: silymarin 35 mg.

Indications

As part of complex therapy:

toxic liver damage

conditions after acute hepatitis

chronic hepatitis of non-viral etiology

liver steatosis (non-alcoholic and alcoholic)

cirrhosis of the liver

prevention of liver damage with prolonged use of drugs, alcohol, chronic intoxication (including occupational).

INN / Active ingredient

dry extract of milk thistle fruit

Storage conditions and periods

At a temperature not exceeding 25 degrees, in the original packaging.

Expiration date: 2 years

Contraindications

Hypersensitivity to the active or any of the excipients of the drug Carsil Forte

lactase deficiency, galactosemia or glucose / galactose malabsorption syndrome (presence of lactose in the preparation)

celiac disease (celiac disease) the presence of wheat starch in the preparation

children under 12 years old.

With caution: patients with hormonal disorders (endometriosis, uterine fibroids, breast, ovarian and uterine carcinoma, prostate carcinoma) may exhibit an estrogen-like effect of silymarin.

Specifications

Category

Hepatoprotectors

Scope of the drug

Gastrointestinal tract

Release form

Dragee

Manufacturer country

Bulgaria

Package quantity, pcs

80

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Sopharma

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Herbal hepatoprotective agent

Anatomical and therapeutic characteristics

A05BA03 Silymarin

Dosage form

Dragee

The target audience

Children

Dosage (volume) of the substance in the preparation

silymarin 35 mg

Expiration date in days

730

Package weight, g

60

Mode of application

:

For adults, Karsil is prescribed 1-2 pills 3 times / day.

If necessary, the daily dose can be increased to 12 tablets (420 mg).

< br> For prophylactic purposes, the drug is prescribed in a daily dose of 2-3 tablets (70-105 mg). < br> The duration of the course of treatment is at least 90 days. < br> For children over 12 years of age, the drug is prescribed in a daily dose based on 5 mg / kg body weight, divided into 2-3 doses. < br> Dragee is taken orally without chewing.

Information on technical characteristics, delivery set, country of manufacture