Carnitine | Carnitine chloride ampoules 100 mg / ml, 5 ml, 10 pcs.

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In stock
SKU
BID471942
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Release form

Injection.
Release form

Injection.

Packing

10 ampoules.

Pharmacological action

Carnitine chloride is an anabolic non-steroidal agent. The drug stimulates metabolic processes, participating in various parts of energy metabolism, It has anabolic, antihypoxic and antithyroid effects, activates lipid metabolism, stimulates regeneration, and increases appetite. Carnitine is a natural substance related to B vitamins. It is a cofactor of metabolic processes that ensure the maintenance of CoA activity. It reduces the main metabolism, slows down the breakdown of protein and carbohydrate molecules. It promotes the penetration of mitochondria through the membranes and the splitting of long chain fatty acids (palmitic and others) with the formation of acetyl-CoA, which is necessary to ensure the activity of pyruvate carboxylase during gluconeogenesis, the formation of ketone bodies, the synthesis of choline and its esters, oxidative phosphorylation and the formation of ATP. Mobilizes fat (the presence of three labile methyl groups) from fat depots. Competitively displacing glucose, includes a fatty acid metabolic shunt, whose activity is not limited by oxygen (unlike aerobic glycolysis), and therefore the drug is effective in conditions of acute hypoxia (including brain) and other critical conditions. It has a neurotrophic effect, inhibits apoptosis, limits the affected area and restores the structure of the nervous tissue. It normalizes protein and fat metabolism, increased basic metabolism in hyperthyroidism (being a partial thyroxine antagonist). The drug restores the alkaline reserve of blood, does not affect the blood coagulation system, reduces the formation of keto acids, increases the resistance of tissues to the influence of toxic decomposition products, activates aerobic processes and inhibits anaerobic glycolysis, has antihypoxic properties, stimulates and accelerates reparative processes.

Indications

Acute cerebrovascular accident - ischemic stroke, transient ischemic attack - in the acute, subacute and recovery periods.

Dyscirculatory encephalopathy.

Traumatic and toxic brain damage. As monotherapy or as part of complex therapy.

Contraindications

Hypersensitivity to carnitine chloride.

Use during pregnancy and lactation

There have been no special studies on the possibility of use during pregnancy and during breast-feeding. The decision to use should be made by assessing the ratio of the possible risk to the child and the benefit to the mother.

Composition of

1 ml of solution contains: 100 mg of carnitine chloride and up to 1 ml of water for injection.

Dosage and administration

The drug is administered intravenously drip slowly (no more than 60 drops per minute!). Before administration, the contents of one or two ampoules are 5-10 ml of a 10% solution of carnitine chloride (0, 5-1 g) - diluted in 200 ml of 0.9% sodium chloride solution for injection. In acute disorders of cerebral circulation, 1 g is prescribed in the first three days once a day, and then 0.5 g per day for 7 days. After 10-12 days, repeated courses are recommended - 0.5 g once a day for 3-5 days.

When prescribing the drug in the subacute and recovery periods, with discirculatory encephalopathy and various brain lesions, patients are administered 0.5-1 g (1-2 ampoules) of the drug once a day for 3-5 days. If necessary, after 12-14 days, a second course is prescribed.

Side effects

Allergic reactions possible.

Muscle weakness is possible in patients with uremia.

With rapid administration (80 drops per minute or more), pain may appear along the veins, passing with a decrease in the rate of administration.

Drug interaction

Glucocorticoids, when used together with carnitine chloride, contribute to its accumulation in tissues (except for the liver).

Other anabolic agents enhance the effect.

Storage conditions

Must be stored out of the reach of children and protected from light at a temperature not exceeding 25 РC.

Expiration

4 years.

Do not use the drug after the expiry date!

Dosage form

solution for injection

Russian cardiological center, Russia

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