Canison plus cream 0.5 + 1 + 10mg, 15 g

• simple and allergic dermatitis (complicated by secondary infection);

• atopic dermatitis (including diffuse neurodermatitis);

• eczema;

• dermatomycosis (dermatophytosis, candidiasis, versicolor versicolor), especially when localized in the groin and large folds of the skin;

• simple chronic lichen (limited neurodermatitis).

Outwardly.

Kanizon Plus cream should be applied in a thin layer to the entire affected skin surface and surrounding tissue 2 times a day - in the morning and at night. To ensure the effectiveness of treatment, Kanizon Plus cream must be applied regularly. The duration of therapy depends on the size and location of the lesion, as well as the patient's response.

If clinical improvement does not occur after 3-4 weeks of treatment, this may be the reason for a more accurate diagnosis.

Cream for external use

1 g

betamethasone dipropionate 640 mcg

clotrimazole 10 mg

gentamicin sulfate 1 mg

• lupus;

• cutaneous manifestations of syphilis;

• chickenpox;

• herpes simplex;

• post-vaccination skin reactions;

• open wounds;

• children under 2 years of age;

• indications of a history of hypersensitivity reactions to any of its components.

With care: pregnancy (I trimester), long-term treatment, use on large areas of the skin or in violation of the integrity of the skin, the use of occlusive dressings (especially in children).

pharmachologic effect

The combined preparation has anti-inflammatory, anti-allergic, antibacterial and antifungal (fungicidal) effects.

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides, it has a bactericidal effect. Highly sensitive gram-negative microorganisms - Proteus spp. (indole positive and indole negative), Escherichia coli, Klebsiella spp .. Salmonella spp., Shigella spp., Campylobacter spp .. Staphylococcus spp. (methicillin-resistant).

Sensitive: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp.

Resistant: Neisseria meningitidis, Treponema pallidum, anaerobic microbes: Streptococcus spp. (except Streptococcus pneumoniae), Enterococcus faecalis; Providencia rettgeri.

Betamethasone is a glucocorticosteroid that has a local anti-inflammatory, vasoconstrictor, antiallergic effect.

Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It acts by disrupting the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Possesses a wide spectrum of action. Effective against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur, Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.

Side effect

Very rarely, when using Canizon Plus cream, the following are noted: burning sensation, erythema, exudation, pigmentation disorders and itching.

Adverse reactions that occur when using local glucocorticosteroids (especially when using occlusive dressings): burning sensation, itching, dry skin, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, the development of a secondary infection, skin atrophy, striae , prickly heat.

Adverse reactions due to clotrimazole: erythema, tingling sensation, blistering, peeling, local edema, itching, urticaria, skin irritation.

Adverse reactions due to gentamicin: transient skin irritation (erythema, pruritus), usually not requiring discontinuation of treatment.

Application during pregnancy and lactation

It is not recommended to use the drug in the first trimester of pregnancy. In clinical and experimental studies, it was not found that the use of clotrimazole during pregnancy has a negative effect on the health of the woman and the fetus. However, the question of the advisability of prescribing the drug in the II and III trimesters of pregnancy should be decided individually after consulting a doctor. The possibility of excretion of clotrimazole in breast milk has not been studied. Therefore, Kanizon Plus, a cream for external use, should be used with caution in nursing mothers.

Application in children

For children, the drug is prescribed only on strict indications and under medical supervision. the development of systemic side effects associated with betamethasone is possible. When using Kanizon Plus cream, like many other topical preparations based on glucocorticosteroids, on large surfaces and / or with an occlusive dressing, the function of the hypothalamic-pituitary-adrenal system may be suppressed, there may be a decrease in the excretion of growth hormone, as well as an increase in intracranial pressure.

special instructions

Kanizon Plus cream is not intended for use in ophthalmology. Avoid getting the cream in the eyes.

Prolonged local use of antibiotics can sometimes lead to the growth of resistant microflora.In this case, as well as with the development of irritation, sensitization or superinfection during treatment with Canison Plus cream, treatment should be discontinued and appropriate therapy should be prescribed. Cross-allergic reactions with aminoglycosidic antibiotics have been observed.

Any side effects that occur with the use of systemic glucocorticosteroids, including suppression of the function of the adrenal cortex, can also be observed with topical application of glucocorticosteroids, especially in children.

Systemic absorption of glucocorticosteroids or gentamicin when applied topically will be higher if the treatment is carried out on large areas of the skin or when using occlusive dressings, especially with long-term treatment or in violation of the integrity of the skin. Avoid applying gentamicin to open wounds and damaged skin. Otherwise, there may be side effects characteristic of gentamicin when used systemically. Appropriate precautions should be taken in such cases, especially when treating children. With prolonged use of the drug, it is recommended to withdraw it gradually.

Use in pediatrics

For children, the drug is prescribed only on strict indications and under medical supervision. the development of systemic side effects associated with betamethasone is possible. When using Kanizon Plus cream, like many other topical preparations based on glucocorticosteroids, on large surfaces and / or with an occlusive dressing, the function of the hypothalamic-pituitary-adrenal system may be suppressed, there may be a decrease in the excretion of growth hormone, as well as an increase in intracranial pressure.

Overdose

Symptoms: with long-term use of local glucocorticosteroids in high doses, it is possible to suppress adrenal function with the development of secondary adrenal insufficiency and symptoms of hypercortisolism, including Cushing's syndrome.

An overdose of clotrimazole when applied topically does not lead to the appearance of any symptoms.

With a single overdose of gentamicin, the appearance of any symptoms is also not expected.

Long-term treatment with gentamicin in high doses can lead to the growth of insensitive flora.

Treatment: symptomatic. Acute symptoms of hypercortisolism are usually reversible. If necessary, the electrolyte imbalance is corrected. In the case of chronic glucocorticosteroid toxicity, gradual withdrawal of glucocorticosteroids is recommended.

Drug interactions

With the simultaneous use of Kanizon Plus with antifungal drugs of other groups, the effectiveness of these drugs used externally decreases. The use of gentamicin can lead to overgrowth of resistant (highly resistant) microorganisms, including fungi. If superinfection occurs as part of a therapeutic course of treatment with gentamicin, the drug should be discontinued and a course of appropriate therapy should be prescribed.