Candide-B6 vaginal tablets with an applicator 100mg, No. 6

Genital infections

caused by yeast-like fungi of the genus Candida (vulvovaginal candidiasis);

sanitation of the birth canal before childbirth.

Candide-B6 is used topically, exclusively intravaginally (oral administration is prohibited).

Vaginal tablets should be inserted as deep as possible into the vagina, once a day (in the evening) for 6 days.

A single dose is 100 mg (one tablet).

Repeated courses are possible after consulting a doctor.

For more convenient administration of the drug, the procedure should be carried out with the woman lying on her back, legs slightly bent.

Before childbirth, in order to sanitize the birth canal, Candide-B6 is administered once, one tablet at a time.

Instructions for using the supplied applicator:

Extend the plunger of the applicator to the stop and place one tablet in the applicator.

Slowly and carefully insert the applicator into the vagina (as deep as possible).

By pressing the piston of the applicator, insert the pill into the vagina (the piston must be pressed in until it stops).

Remove the applicator carefully.

After the procedure and before using the applicator again, remove the plunger completely, rinse the applicator and plunger with warm soapy water and wipe dry

active substance:

clotrimazole - 100 mg;

auxiliary components:

colloidal silicon dioxide,

methyl parahydroxybenzoate,

povidone K-30,

adipic acid,

lactose monohydrate,

sodium bicarbonate,

propyl parahydroxybenzoate,

corn starch,

magnesium stearate,

sodium carboxymethyl starch,

talc.

Hypersensitivity to clotrimazole; I trimester of pregnancy, period of menstruation.

Candide-B6 is an antifungal drug for local use in gynecological practice.

Release form:

The drug is produced in the form of vaginal tablets: oval, biconvex, truncated on one side, white, without a shell, on one side with a 'V6' sign, on the other - with a 'G' monogram (6 pcs. In strips of aluminum foil, in a cardboard box one strip complete with an applicator and instructions for use of Candida-B6).

Composition for one tablet:

active substance:

clotrimazole - 100 mg;

auxiliary components:

colloidal silicon dioxide,

methyl parahydroxybenzoate,

povidone K-30,

adipic acid,

lactose monohydrate,

sodium bicarbonate,

propyl parahydroxybenzoate,

corn starch,

magnesium stearate,

sodium carboxymethyl starch,

talc.

pharmachologic effect

Broad-spectrum antifungal agent for vaginal use. The action of clotrimazole is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which changes the permeability of the cytoplasmic membrane and causes subsequent cell lysis. In small concentrations, it acts fungistatically, in large concentrations it is fungicidal, and not only on proliferating cells. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Clotrimazole exhibits fungicidal and fungistatic activity against dermatomycetes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast-like and mold fungi (Candida spp., Including Candida spp., Including Candida Rusta albicans; Torulopsis albicans; Torulopsis genus, Torulopsis albicans; Active against the causative agent of varicoloured lichen - Pityrosporum orbiculare (Malasseziafurfur). Effective against gram-positive bacteria - the causative agent of erythrasma Corynebacterium minutissimum, as well as Staphylococcus spp., Streptococcus spp., Gram-negative bacteria - Bacteroides, Gardnerella vaginalis. In high concentrations, it is active against Trichomonas vaginalis.

Does not affect lactobacilli. Primarily resistant variants of sensitive fungi are very rare; the development of secondary resistance in sensitive fungi is also observed in exceptional cases under therapeutic conditions.

Pharmacokinetics

When using clotrimazole intravaginally, absorption is 3-10% of the administered dose. High concentrations in vaginal secretions and low concentrations in blood persist for 48-72 hours. In the liver, it is metabolized to inactive metabolites excreted from the body by the kidneys and through the intestines.

Indications

Genital infections

caused by yeast-like fungi of the genus Candida (vulvovaginal candidiasis);

sanitation of the birth canal before childbirth.

Contraindications

Hypersensitivity to clotrimazole; I trimester of pregnancy, period of menstruation.

Method of administration and dosage:

Candide-B6 is used topically, exclusively intravaginally (oral administration is prohibited).

Vaginal tablets should be inserted as deep as possible into the vagina, once a day (in the evening) for 6 days.

A single dose is 100 mg (one tablet).

Repeated courses are possible after consulting a doctor.

For more convenient administration of the drug, the procedure should be carried out with the woman lying on her back, legs slightly bent.

Before childbirth, in order to sanitize the birth canal, Candide-B6 is administered once, one tablet at a time.

Instructions for using the supplied applicator:

Extend the plunger of the applicator to the stop and place one tablet in the applicator.

Slowly and carefully insert the applicator into the vagina (as deep as possible).

By pressing the piston of the applicator, insert the pill into the vagina (the piston must be pressed in until it stops).

Remove the applicator carefully.

After the procedure and before using the applicator again, remove the plunger completely, rinse the applicator and plunger with warm soapy water and wipe dry

Side effects

From the immune system: allergic reactions, incl. urticaria, shortness of breath, arterial hypotension, fainting.

From the digestive system: frequency unknown - abdominal pain.

From the urinary system: the frequency is unknown - frequent urination, intercurrent cystitis.

From the reproductive system: the frequency is unknown - itching, burning, hyperemia and edema of the vaginal mucosa, ulceration of the vaginal mucosa, rash, pain in the pelvic region, burning sensation in the penis in a sexual partner, pain during intercourse.

Others: frequency unknown - headache.

Drug interactions

With simultaneous use with amphotericin B, nystatin, the activity of clotrimazole decreases.

The simultaneous use of intravaginal clotrimazole and oral tacrolimus, sirolimus can lead to an increase in the concentration of the latter in the blood plasma, therefore, patients should be monitored for the development of symptoms of overdose, if necessary, with the measurement of plasma concentrations.

special instructions

If allergic reactions or irritation occurs at the site of application of the product, treatment is stopped.

Hygiene rules should be followed to prevent reinfection.

Application of clotrimazole to the skin around the eyes is not recommended.

If clinical signs of infection persist after completion of treatment, a second microbiological study should be performed to confirm the diagnosis.

To prevent infection / reinfection with genital infections, simultaneous treatment of sexual partners is necessary. During the period of treatment, it is recommended to refrain from sexual intercourse.

When using dosage forms intended for local intravaginal use, it is recommended to use reliable contraception. The risk of rupture of the condom or diaphragm increases when used concomitantly with clotrimazole.

Pregnancy and lactation

Use is contraindicated in the first trimester of pregnancy.

Application in the II-III trimesters of pregnancy is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.

If necessary, use during lactation should decide on the termination of breastfeeding.

Terms and conditions of storage

Store in a place protected from light and moisture at a temperature of + 2 ... +25 ? —.

Keep out of the reach of children.

Shelf life is 4 years.

Conditions of dispensing from pharmacies

Available without a prescription.