Caffeine-sodium benzoate tablets 100mg, No. 10

• Decreased mental and physical performance

• drowsiness

• headache of vascular origin (including migraine)

• moderate arterial hypotension.

Assign inside regardless of the meal. Do not take at bedtime.

With a decrease in the mental and physical performance of drowsiness - for adults and children over 12 years old - 50 - 100 mg 2-3 times a day. The course of treatment is from several weeks to several months, depending on the patient's condition.

For headaches of vascular origin (including migraine) - for adults and children over 12 years old - 50-100 mg 2-3 times a day for several days.

With moderate arterial hypotension - adults and children over 12 years old - 50 - 100 mg 2-3 times a day. The course of treatment is several weeks.

The highest single dose for adults is 300 mg; the highest daily dose for adults is 1000 mg;

The highest single dose for children from 12 years old is 150 mg; the highest daily dose for children is 500 mg.

For 1 tablet:

Active ingredient : caffeine-sodium benzoate-100 mg;

Excipients : potato starch - 15.77 mg, calcium stearate - 0.23 mg;

• Hypersensitivity to drug components (including other xanthines)

• anxiety disorders (agoraphobia panic disorder)

• organic diseases of the cardiovascular system (including acute myocardial infarction atherosclerosis)

• paroxysmal tachycardia

• ventricular premature beats

• arterial hypertension

• sleep disturbances

• children under 12 years of age.

Carefully:

Glaucoma, hyperexcitability, advanced age, epilepsy, and a tendency to seizures.

Trade name of the drug

Caffeine-sodium benzoate

International non-proprietary name

Caffeine

Dosage form

pills

Composition

For 1 tablet:

Active ingredient : caffeine-sodium benzoate-100 mg;

Excipients : potato starch - 15.77 mg, calcium stearate - 0.23 mg;

Description

Tablets of white color of a flat-cylindrical shape with a beveled and scored.

Pharmacotherapeutic group

Psychostimulant

ATX code

N06BC01

Pharmacodynamics:

Caffeine is a methylxanthine that has a psychostimulating and analeptic effect.

Competitively blocks central and peripheral AT and A2 adenosine receptors. Inhibits the activity of phosphodiesterase in the central nervous system of the heart of smooth and striated muscle tissue of adipose tissue contributes to the accumulation of adenosine monophosphate and cyclic guanosine monophosphate in them (this effect is observed when only high doses of caffeine are used). It stimulates the centers of the medulla oblongata (respiratory and vasomotor) and also the center of the vagus nerve has a direct stimulating effect on the cerebral cortex. In high doses' relieves. Interneuronal conduction in the spinal cord enhancing reflexes.

Increases mental and physical performance; stimulates mental activity; physical activity; shortens the reaction time; temporarily reduces fatigue and drowsiness. In low doses, the effect of stimulation predominates, and in large doses, the effect of depression of the nervous system.

Speeds up and deepens breathing usually has a positive ino-chrono-batmo- and dromotropic effect (since the effect on the cardiovascular system consists of a direct stimulating effect on the myocardium and a simultaneous stimulating effect on the center of the vagus nerve, the resulting effect depends on the predominance of one or another action ).

It stimulates the vasomotor center and has a direct relaxing effect on the vascular wall, which leads to the expansion of the vessels of the heart of the skeletal muscles and kidneys, while the tone of the cerebral arteries increases (causes a narrowing of the vessels of the brain, which is accompanied by a decrease in cerebral blood flow). Blood pressure changes under the action of the vascular and cardiac mechanisms of caffeine influence: at normal initial blood pressure, caffeine does not change or slightly increases it with arterial hypotension, increases it.

It has an antispasmodic effect on smooth muscles (including bronchodilating effect) on striated muscles - stimulating. Increases the secretory activity of the stomach and diuresis (a decrease in the reabsorption of sodium and water in the proximal and distal renal tubules as well as vasodilation of the kidneys and an increase in filtration in the renal glomeruli).

Reduces platelet aggregation and the release of histamine from mast cells. Increases basal metabolism: increases glycogenolysis and increases lipolysis.

Pharmacokinetics:

When taken orally, absorption is good; occurs throughout the intestine. It is quickly distributed in all organs and tissues of the body and penetrates the blood-brain barrier and the placenta. The maximum concentration in blood plasma is reached after 50-75 minutes; the half-life is 39-53 hours (sometimes up to 10 hours). Connection with blood proteins (albumin) - 15%. More than 90% of children in the first years of life undergo metabolism in the liver, up to 10-15%. Caffeine is metabolized in the liver (the main part is dimethylated and oxidized) to form 5 metabolites. The excretion of caffeine and its metabolites is carried out by the kidneys (10% unchanged).

Indications:

• Decreased mental and physical performance

• drowsiness

• headache of vascular origin (including migraine)

• moderate arterial hypotension.

Contraindications:

• Hypersensitivity to drug components (including other xanthines)

• anxiety disorders (agoraphobia panic disorder)

• organic diseases of the cardiovascular system (including acute myocardial infarction atherosclerosis)

• paroxysmal tachycardia

• ventricular premature beats

• arterial hypertension

• sleep disturbances

• children under 12 years of age.

Carefully:

Glaucoma, hyperexcitability, advanced age, epilepsy, and a tendency to seizures.

Pregnancy and lactation:

Use is possible only after consulting a doctor if the expected benefit to the mother outweighs the potential risk to the fetus.

Method of administration and dosage:

Assign inside regardless of the meal. Do not take at bedtime.

With a decrease in the mental and physical performance of drowsiness - for adults and children over 12 years old - 50 - 100 mg 2-3 times a day. The course of treatment is from several weeks to several months, depending on the patient's condition.

For headaches of vascular origin (including migraine) - for adults and children over 12 years old - 50-100 mg 2-3 times a day for several days.

With moderate arterial hypotension - adults and children over 12 years old - 50 - 100 mg 2-3 times a day. The course of treatment is several weeks.

The highest single dose for adults is 300 mg; the highest daily dose for adults is 1000 mg;

The highest single dose for children from 12 years old is 150 mg; the highest daily dose for children is 500 mg.

Side effects:

From the side of the central nervous system : psychomotor agitation anxiety tremors anxiety headache dizziness epileptic seizures increased reflexes tachypnea insomnia; with sudden cancellation - increased inhibition of the central nervous system; increased fatigue; drowsiness; muscle tension.

From the side of the cardiovascular system : palpitations, tachycardia, increased blood pressure.

From the digestive system : nausea, vomiting, exacerbation of peptic ulcer disease.

Others : nasal congestion with prolonged use - addictive drug dependence.

Overdose:

Symptoms : gastralgia agitation anxiety agitation motor restlessness confusion delirium dehydration tachycardia arrhythmia hyperthermia frequent urination headache increased tactile or pain sensitivity tremors or muscle twitching; nausea and vomiting, sometimes with blood; tinnitus convulsions (in acute overdose - tonic-clonic).

Caffeine in doses of more than 300 mg / day (including against the background of coffee abuse - more than 4 cups of natural coffee, 150 ml each) can cause anxiety, tremors, headaches, confusion, extrasystole.

Treatment : gastric lavage; - if caffeine was taken in the last 4 hours at a dose of more than 15 mg / kg and there was no vomiting caused by caffeine; taking activated charcoal laxative drugs; with hemorrhagic gastritis - the introduction of antacid drugs and gastric lavage with ice-cold 09% sodium chloride solution; maintenance of ventilation and oxygenation; for convulsions - IV diazepam phenobarbital or phenytoin; maintaining water and electrolyte balance.

Interaction:

Caffeine is an adenosine antagonist (large doses of adenosine may be required).

With the combined use of caffeine and primidone barbiturates, anticonvulsant drugs (hydantoin derivatives, especially phenytoin), it is possible to increase metabolism and increase the clearance of caffeine; cimetidine oral contraceptive disulfiram ciprofloxacin norfloxacin - decrease in the metabolism of caffeine in the liver .. (slowing down its excretion and increasing concentration in the blood).

Caffeinated drinks and other drugs that stimulate the central nervous system - the central nervous system may be overstimulated.

Mexiletin - reduces the excretion of caffeine by 50%; nicotine - increases the rate of caffeine elimination.

Monoamine oxidase inhibitors furazolidone procarbazine and selegiline - large doses of caffeine (more than 300 mg / day) can cause the development of life-threatening cardiac arrhythmias or - a pronounced increase in blood pressure.

Caffeine reduces the absorption of calcium supplements in the gastrointestinal tract.

Reduces the effectiveness of narcotic and sleeping pills.

Increases the excretion of lithium preparations in the urine;

Accelerates absorption and enhances the action of cardiac glycosides and increases their toxicity. Combined use with beta-blockers can lead to mutual suppression of therapeutic effects; with? -adrenomimetics - to additional stimulation of the central nervous system and other additive toxic effects.

Caffeine can reduce clearance; theophylline and possibly other xanthines increasing the possibility of additive pharmacodynamic and toxic effects.

Special instructions:

It should be borne in mind that a sudden cessation of admission can lead to increased inhibition of the central nervous system (drowsiness, depression).

The effect on the central nervous system depends on the type of the nervous system and can be manifested both by excitation and inhibition of higher nervous activity.

Due to the fact that the effect of caffeine on blood pressure consists of the vascular and cardiac components, as a result, both the effect of stimulating the heart and oppression (weak) of its activity can develop.

Do not take at bedtime.

Impact on the ability to drive vehicles. Wed and fur .:

During the period of treatment, care must be taken when driving vehicles and engaging in potentially hazardous activities requiring concentration of attention and speed of psychomotor reactions.

Release form / dosage:

Tablets 100 mg.

Packaging:

There are 6 or 10 tablets in a contour cell-free package or 10 tablets in a contour cell package. 1 or 2 blister packs together with instructions for use are placed in a cardboard box. Contour cell packaging and contour non-cell packaging with an equal number of instructions for use are placed directly in the group packaging.

Storage conditions:

In a dry, dark place at a temperature not exceeding 25 ? C.

Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date indicated on the package.

Vacation conditions

On prescription.