Bromhexine, Gvayfenezin, Salbutamol | Ascoril tablets, 10 pieces.

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SKU
BID467362
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Latin name

Ascoril
Latin name

Ascoril

release form

tablets



packaging 10 pcs

Pharmacological action

Ascoril - bronchodilator, mucolytic, expectorant.

Pharmacodynamics

Combined drug, has a bronchodilator, expectorant and mucolytic effect.

Salbutamol - a bronchodilator, stimulates beta2-adrenergic receptors of the bronchi, blood vessels and myometrium. Prevents or eliminates bronchospasm, reduces airway resistance, increases lung capacity. It causes the expansion of coronary arteries, does not reduce blood pressure.

Bromhexine is a mucolytic agent that has an expectorant and antitussive effect. Increases the serous component of the bronchial secretion activates the cilia of the ciliated epithelium, reduces the viscosity of sputum, increases its volume and improves discharge.

Guaifenesin is a mucolytic agent that reduces the surface tension of the structures of the bronchopulmonary apparatus, stimulates the secretory cells of the bronchial mucosa, producing neutral polysaccharides, depolymerizes acid mucopolysaccharides, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, facilitates the removal of sputum and facilitates the transition of unproductive cough.

Pharmacokinetics

Salbutamol

When administered, absorption is high. Eating reduces the rate of absorption, but does not affect bioavailability. Communication with plasma proteins - 10%. Penetrates through the placenta. It undergoes a presystemic metabolism in the liver and intestinal wall, by phenol sulfotransferase inactivates up to 4-o-sulfate ester. T1 / 2 - 3.8-6 hours. It is excreted by the kidneys (69–90%), mainly in the form of an inactive phenol sulfate metabolite (60%) for 72 hours and with bile (4%). The bioavailability of orally administered salbutamol is about 50%.

Bromhexine

When ingested, it is almost completely (99%) absorbed in the digestive tract within 30 minutes. Bioavailability is low (the effect of the primary passage through the liver). Penetrates through the placental barrier and the BBB. In the liver, it undergoes demethylation and oxidation, is metabolized to pharmacologically active ambroxol. T1 / 2 - 15 hours (due to slow back diffusion from tissues). It is excreted by the kidneys. With chronic renal failure, the excretion of metabolites is impaired. With repeated use, it can accumulate.

Guaifenesin

Absorption from the gastrointestinal tract is fast (25-30 minutes after ingestion). T1 / 2 - 1 hour. Penetrates into tissues containing acidic mucopolysaccharides. Approximately 60% of the drug administered is metabolized in the liver. It is excreted by the lungs (with sputum) and kidneys both unchanged and in the form of inactive metabolites.

Indications

bronchial asthma

tracheobronchitis

obstructive bronchitis

pneumonia

pulmonary emphysema

whooping cough

pneumoconiosis

pulmonary tuberculosis.

Contraindications

hypersensitivity to the components of the drug

tachyarrhythmia, myocarditis

heart defects

decompensated diabetes mellitus

thyrotoxicosis

glaucoma

hepatic or renal failure

gastric and duodenal ulcer in the acute stage

gastric bleeding srdlp period lactation srdlp pregnancy

Precautions: diabetes mellitus gastric and duodenal ulcer in remission.

Use during pregnancy and lactation

During pregnancy, the use of the drug is not recommended.

If treatment with the drug is necessary during lactation, breast-feeding should be discontinued.

Composition of

1 tablet contains:

Active ingredients:

salbutamol - 2 mg,

bromhexine - 8 mg,

guaifenesin - 100 mg

Excipients:

calcium hydrogen phosphate

starch corn

methyl parahydroxybenzoate (methyl paraben)

propyl parahydroxybenzoate (propyl paraben)

talc purified

silicon dioxide colloidal magnesium

magnesium stea.

Dosage and Administration

Inside. Adults and children over 12 years old - 1 tablet 3 times a day for children from 6 to 12 years old - 1/2 or 1 tablet 3 times a day.

Children under 6 years of age are recommended to use Ascoril Exectorant Syrup.

Side effects of

Rarely when used at high doses:

headache,

dizziness,

sleep disturbance,

sleep disturbance,

drowsiness,

tremor, cramps, cramps, cramps, cramps, cramps, cramps stomach and duodenum,

heart palpitations,

may stain urine pink,

allergic reactions (rash, urticaria),

collapse,

bronchospasm.

Drug Interactions

Other beta2-adrenergic agonists and theophylline enhance the effects of salbutamol and increase the likelihood of side effects.

Ascoril is not prescribed simultaneously with drugs containing codeine and other antitussive drugs, as this makes it difficult to discharge liquefied sputum.

Ascoril bromhexine, which is part of the drug, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

It is not recommended to use the drug Ascoril simultaneously with non-selective beta-adrenergic receptor blockers, such as propranolol.

Ascoril salbutamol, a part of the drug, is not recommended for patients who receive MAO inhibitors.

Diuretics and GCS drugs enhance the hypokalemic effect of salbutamol.

It is not recommended to take along with the drug Ascoril alkaline drink.

Overdose

Symptoms: increased side effects.

Treatment: symptomatic therapy.

Storage Conditions

Store in a dark place at a temperature not exceeding 25 РC.

Shelf life

2 years

Active ingredient

Bromhexin, Gufifesin, Salbutamol

Dosage PMA



Prescribing

Prescribing

For adults as prescribed by a doctor, Children over 6 years old, As prescribed by a doctor

Glenmark Pharmaceuticals Ltd., India

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