Bromhexine tablets 8mg, No. 50

Diseases of the respiratory tract, accompanied by the formation of a viscous secretion that is difficult to separate:

tracheobronchitis,

chronic bronchitis with a broncho-obstructive component,

bronchial asthma,

cystic fibrosis,

chronic pneumonia.

Inside for adults and children over 10 years old - 8 mg 3-4 times / day. Children under the age of 2 years - 2 mg 3 times / day; at the age of 2 to 6 years - 4 mg 3 times / day; at the age of 6 to 10 years - 6-8 mg 3 times / day. If necessary, the dose can be increased for adults up to 16 mg 4 times / day, for children - up to 16 mg 2 times / day.

bromhexine hydrochloride

Hypersensitivity to bromhexine.

pharmachologic effect

Mucolytic agent with expectorant action. Reduces the viscosity of bronchial secretions by depolarizing the acidic polysaccharides contained in it and stimulating the secretory cells of the bronchial mucosa, which produce secretions containing neutral polysaccharides. It is believed that bromhexine promotes the formation of a surfactant.

Pharmacokinetics

Bromhexine is rapidly absorbed from the gastrointestinal tract and is extensively metabolized during the 'first pass' through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 hour. It is widely distributed in the tissues of the body. About 85-90% is excreted in the urine mainly in the form of metabolites. The metabolite of bromhexine is ambroxol. Plasma protein binding of bromhexine is high. T1 / 2 in the terminal phase is about 12 hours. Bromhexine penetrates the BBB. In small quantities, it crosses the placental barrier. Only small amounts are excreted in the urine with T1 / 2 6.5 hours. The clearance of bromhexine or its metabolites may decrease in patients with severely impaired liver and kidney function.

Side effect

On the part of the digestive system: dyspeptic symptoms, a transient increase in the activity of hepatic transaminases in the blood serum. From the side of the central nervous system: headache, dizziness. Dermatological reactions: increased sweating, skin rash. From the respiratory system: cough, bronchospasm.

Application during pregnancy and lactation

During pregnancy and lactation, bromhexine is used in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

special instructions

With gastric ulcer, as well as with indications of gastric bleeding in the anamnesis, bromhexine should be used under the supervision of a physician. Use with caution in patients with bronchial asthma. Bromhexine is not used simultaneously with drugs containing codeine, because this makes it difficult to cough up the liquefied sputum. It is used as part of combined herbal preparations with essential oils (including with eucalyptus oil, anise oil, peppermint oil, menthol).

Drug interactions

Bromhexine is incompatible with alkaline solutions.