Berotek N aerosol 100mkg / dose, 200 dose

Prevention and relief of broncho-obstructive syndrome: with bronchial asthma, chronic bronchitis (including complicated by emphysema), spastic bronchitis in children; bronchopulmonary diseases (silicosis, bronchiectasis, tuberculosis). Preparation before administration of medicinal products in aerosols (including antibiotics, mucolytic agents, GCS). Conducting bronchodilation tests in the study of the function of external respiration.

For use in obstetrics: the threat of premature birth, the threat of spontaneous miscarriage after 16 weeks of pregnancy.

For inhalation use to relieve bronchospasm, a single dose for adults and children over 6 years of age is 200 mcg. The frequency of use depends on the clinical situation, the interval between inhalations is at least 3 hours.

For the prevention of asthma attacks, a single dose is 200 mcg for adults - 3 times / day, for children over 6 years old - 2 times / day. Children aged 4 to 6 years - 100 mg 4 times / day. The frequency of use in patients of all ages is no more than 4 times / day.

When used as a tocolytic agent, the dosage regimen is established taking into account the clinical situation. For oral administration - 5 mg every 3-6 hours. With intravenous drip, the initial dose is 50 mcg / min.

Maximum doses: when used as a tocolytic agent inside - 40 mg / day, intravenous drip - 300 mcg / min.

Dosed colorless aerosol for inhalation

Active substance:

fenoterol hydrobromide

Hypertrophic obstructive cardiomyopathy, tachyarrhythmias, thyrotoxicosis, hypersensitivity to fenoterol.

For use in obstetrics: heart disease, multiple pregnancies, preeclampsia, eclampsia, spotting with placenta previa, premature detachment of a normal or low placenta, fetal heart rhythm disturbances, fetal abnormalities, intrauterine fetal death, intrauterine infections.

pharmachologic effect

Beta agonist. Acts primarily on? 2-adrenergic receptors. The mechanism of action is associated with the activation of adenylate cyclase coupled with the receptor, which leads to an increase in the formation of c-AMP, which stimulates the work of the calcium pump, as a result of which the concentration of calcium in the myofibrils decreases.

When used as a bronchodilator, it expands the bronchi, increases the frequency and volume of respiration, and improves the function of the ciliated epithelium of the bronchi. It has a vasodilating effect, reduces the contractile activity and tone of the myometrium.

As a tocolytic agent, it is used orally and intravenously. Along with a decrease in the tone and contractile activity of the myometrium, it improves the uteroplacental blood flow, which leads to an increase in the oxygen concentration in the fetal blood.

Indications of the active substances of the drug

Prevention and relief of broncho-obstructive syndrome: with bronchial asthma, chronic bronchitis (including complicated by emphysema), spastic bronchitis in children; bronchopulmonary diseases (silicosis, bronchiectasis, tuberculosis). Preparation before administration of medicinal products in aerosols (including antibiotics, mucolytic agents, GCS). Conducting bronchodilation tests in the study of the function of external respiration.

For use in obstetrics: the threat of premature birth, the threat of spontaneous miscarriage after 16 weeks of pregnancy.

Dosage regimen

For inhalation use to relieve bronchospasm, a single dose for adults and children over 6 years of age is 200 mcg. The frequency of use depends on the clinical situation, the interval between inhalations is at least 3 hours.

For the prevention of asthma attacks, a single dose is 200 mcg for adults - 3 times / day, for children over 6 years old - 2 times / day. Children aged 4 to 6 years - 100 mg 4 times / day. The frequency of use in patients of all ages is no more than 4 times / day.

When used as a tocolytic agent, the dosage regimen is established taking into account the clinical situation. For oral administration - 5 mg every 3-6 hours. With intravenous drip, the initial dose is 50 mcg / min.

Maximum doses: when used as a tocolytic agent inside - 40 mg / day, intravenous drip - 300 mcg / min.

Side effect

From the side of the cardiovascular system: possible palpitations, tachycardia, anginal pain, rarely - a drop in diastolic blood pressure.

From the side of the central nervous system: anxiety, minor tremor, nervousness, anxiety, dizziness, headache are possible.

From the digestive system: nausea, belching, vomiting, deterioration of intestinal motility are possible.

From the side of metabolism: an increase in the concentration of glucose in the blood is possible.

From the respiratory system: cough; rarely - paradoxical bronchospasm.

Others: increased sweating, weakness, muscle pain and spasms, hypokalemia, hyperglycemia, decreased motility of the upper urinary tract, tolerance are possible; rarely - allergic reactions.

Contraindications for use

Hypertrophic obstructive cardiomyopathy, tachyarrhythmias, thyrotoxicosis, hypersensitivity to fenoterol.

For use in obstetrics: heart disease, multiple pregnancies, preeclampsia, eclampsia, spotting with placenta previa, premature detachment of a normal or low placenta, fetal heart rhythm disturbances, fetal abnormalities, intrauterine fetal death, intrauterine infections.

Application during pregnancy and lactation

During pregnancy, it is used intravenously or internally according to indications and taking into account contraindications.

In the form of inhalation, it is used with caution in the first trimester of pregnancy.

Fenoterol is excreted in breast milk. The safety of use during lactation has not been established, therefore, if therapy is necessary, the issue of stopping breastfeeding should be resolved.

Application in children

Application is possible in children over 6 years of age according to the dosage regimen.

Use in elderly patients

The drug is contraindicated for use in elderly patients.

special instructions

It is used with caution in diabetes mellitus, recent myocardial infarction, severe diseases of the cardiovascular system, hyperthyroidism, pheochromocytoma. It should be borne in mind that with an overdose of fenoterol, the development of irreversible bronchial obstruction is possible.

When used in obstetrics in patients with impaired water metabolism, impaired functions of the cardiovascular system and the respiratory system, one should bear in mind the possibility of developing pulmonary edema.

During the period of use of fenoterol, it is recommended to control the level of potassium in the blood; when taken orally or intravenously, it is necessary to control blood pressure, heart rate of the patient and fetal heart rate.

Fenoterol should be used with caution at the same time as GCS.

It is not recommended to use fenoterol simultaneously with calcium preparations, vitamin D preparations, mineralocorticoids.

Drug interactions

Beta-adrenergic, anticholinergics, xanthine derivatives, corticosteroids and diuretics can increase the action and side effects of fenoterol (especially in hypokalemia).

A significant decrease in the effectiveness of fenoterol is possible with the simultaneous use of beta-blockers.

With simultaneous use with MAO inhibitors and tricyclic antidepressants, an increase in the effect of fenoterol is noted.

Inhalation of halogenated hydrocarbon anesthetics (halothane, trichlorethylene, enflurane) can enhance the effect of fenoterol on the cardiovascular system.

The simultaneous appointment of bronchodilators with a similar mechanism of action leads to an additive effect and overdose phenomena.

Ftorotan sensitizes the myocardium to the action of fenoterol, promotes the development of arrhythmias.