Benzylpenicillin sodium salt for injection 1 million units

DESCRIPTION

Benzylpenicillin sodium salt is a drug for the treatment of diseases of bacterial etiology in farm animals, dogs and fur animals. Dosage form: powder for solution for injection. In appearance, the drug is a fine crystalline powder of white or slightly yellowish color.

COMPOSITION

The drug contains benzylpenicillin sodium salt as an active ingredient - not less than 1650 U / mg (in terms of dry matter).

PHARMACOLOGICAL PROPERTIES

Benzylpenicillin sodium salt for injection belongs to the antibacterial drugs of the penicillin group.

Benzylpenicillin sodium salt is a salt of benzylpenicillinic acid produced by Penicillium notatum, it is active against gram-positive microorganisms (streptococci, staphylococci, pneumococci, enterococci, most anaerobes, actinomycetes, clostridium cochlea, some Siberian cocci) ...

The antimicrobial action of benzylpenicillin sodium salt is based on the suppression of the biosynthesis of the cell wall of the microorganism, which is based on a complex peptidoglycan. Penicillins inhibit the activity of enzymes involved in the synthesis of peptidoglycan, which stops the growth of microorganisms. At the same time, enzymes that hydrolyze peptidoglycan are activated, and the covalent bonds of the cell wall are disrupted. Growing cells stop dividing, swell and disintegrate.

After intramuscular injection of benzylpenicillin, sodium salt is rapidly absorbed into the bloodstream, distributed in the extracellular fluid, and penetrates into organs and tissues. The maximum concentration of the antibiotic in the blood is reached 30 minutes after administration and is maintained at a therapeutic level for 4-6 hours. It is excreted from the body, mainly in the urine; the rest - with bile, milk.

Benzylpenicillin sodium salt for injection, according to the degree of exposure to the body, belongs to hazard class 2 according to GOST 12.1.007 (highly hazardous substances).

The use of benzylpenicillin sodium salt for injection in the early stages of pregnancy can increase the contractile activity of the uterus and increase the number of spontaneous abortions. Penicillins cross the placenta. With the introduction of penicillins in doses of 2-25 (for different penicillins) exceeding therapeutic ones, fertility disorders and effects on reproductive function were not found. No teratogenic, mutagenic, or embryotoxic properties have been identified when penicillins were administered to animals.

INDICATIONS

Benzylpenicillin sodium salt for injection is used to treat anthrax, necrobacteriosis, pasteurellosis, pneumonia, mastitis, endometritis, wound infection, emphysematous carbuncle and streptococcal septicemia in cattle and small ruminants; myta and catarrhal pneumonia of horses; streptococcosis and staphylococcosis of fur animals and dogs; erysipelas of pigs and other diseases, pathogens of which are sensitive to benzylpenicillin.

APPLICATION

Before use, the drug is dissolved in 5-10 ml of water for injection or sterile isotonic sodium chloride solution by piercing the bottle cap with a needle.

The prepared solution is injected intramuscularly with an interval of 4-6 hours for 5-7 days in the following doses (according to the active substance):

Kind of animal Single dose (thousand units / kg of animal weight)

Adults Young growth

Cattle 3 five

Horses 2 3

Small cattle 4 1

Pigs 6 8

Furry animals, dogs ten 20

* Note young cattle and pigs - animals up to 6 months of age, small cattle - up to 4 months of age, horses, dogs and fur animals - up to 1 year.

If you accidentally skip the introduction of the next dose of the drug, it should be administered as soon as possible in the prescribed dosages and regimen.

SPECIAL INSTRUCTIONS

Slaughter of animals for meat is allowed no earlier than 3 days after the last use of the drug. Meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding carnivores.

Milk obtained from animals during the treatment period and within 24 hours after the last injection of Benzylpenicillin sodium salt for injection must not be used for food purposes. Such milk can be used after heat treatment for feeding animals.

CONTRAINDICATIONS

A contraindication for the use of benzylpenicillin sodium salt for injection is the individual hypersensitivity of the animal to antibiotics of the penicillin group.

The simultaneous use of benzylpenicillin sodium salt for injection with other antibiotics (aminoglycosides, tetracyclines, chloramphenicol), adrenaline, euphilin, ascorbic acid, B vitamins and non-steroidal anti-inflammatory drugs is prohibited.

OVERDOSE

In case of an overdose of the drug, the animal may experience neurotoxic symptoms (nausea, vomiting, increased reflex excitability). In these cases, the drug is canceled and the animal is prescribed specific and symptomatic therapy.

SIDE EFFECTS

When using Benzylpenicillin sodium salt for injection in accordance with this instruction, side effects and complications are usually not observed. With increased individual sensitivity of the animal to benzylpenicillin sodium salt and the appearance of allergic reactions (urticaria, diarrhea, angioedema, anaphylactic shock), the use of the drug is discontinued and desensitizing therapy is carried out.

PRECAUTIONS

When working with Benzylpenicillin sodium salt for injection, you should follow the general rules of personal hygiene and safety precautions provided when working with medicinal products. People with hypersensitivity to the components of the drug should avoid direct contact with Benzylpenicillin sodium salt for injection.

FIRST AID MEASURES

In case of accidental contact of the drug with the skin or mucous membranes of the eye, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (you should have instructions for use of the drug and a label with you).

SHELF LIFE AND STORAGE

Benzylpenicillin sodium salt for injection is stored in the manufacturer's sealed packaging, separately from food and feed, in a place protected from direct sunlight at a temperature of 5 В° C to 25 В° C. The shelf life of the medicinal product, subject to storage conditions, is 3 years from the date of production.

PACKAGING

The drug is produced packaged in 1,000,000 units. active substance in glass bottles with a capacity of 10 ml.

Specifications

KolVUP

50

Manufacturer

BioFarmGarant

Temperature regime

from +5 to +25

Teaser

a drug for the treatment of diseases of bacterial etiology in farm animals, dogs and fur animals