Beclomethasone-Aeronativ aerosol 250 ?g / dose, 200 dose

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen. Beclomethasone is used regularly (even in the absence of symptoms).

The dose and treatment regimen depends on the age, the severity of the course of bronchial asthma, the clinical effect in each case.

For inhalation administration of beclomentazone dipropionate, special inhalation devices can be used (in accordance with the dosage form used).

Adults and children aged 12 years and older: The daily dose is 200-2000 mcg.

Children aged 4 to 12 years: The daily dose is 100-400 mcg.

Aerosol for inhalation, dosed in the form of a colorless or almost colorless solution, under pressure in an aluminum cylinder with a dosing valve, equipped with a spray nozzle with a protective cap; the drug at the outlet from the cylinder is sprayed in the form of an aerosol jet.

Active substance:

beclomethasone

Tuberculosis (active and inactive); children under 4 years of age; children and adolescents up to 18 years of age (for dosage forms containing 250 mcg of beclomethasone in 1 dose); hypersensitivity to beclomethasone.

pharmachologic effect

GCS for inhalation use. Beclomethasone dipropionate is a prodrug and has a weak affinity for glucocorticoid receptors. Under the action of esterases, it turns into an active metabolite - beclomethasone-17-monopropionate, which has a pronounced local anti-inflammatory effect by reducing the formation of chemotaxis substance (effect on delayed-type allergic reactions). By suppressing the production of metabolites of arachidonic acid and reducing the release of inflammatory mediators from mast cells, it inhibits the development of an immediate allergic reaction.

It improves mucociliary transport, reduces the number of mast cells in the bronchial mucosa, reduces epithelial edema, mucus secretion by the bronchial glands, bronchial hyperreactivity, marginal accumulation of neutrophils, inflammatory exudate and lymphokine production, inhibits the migration of macrophages, reduces the intensity of infiltration and granulation processes.

After inhalation, it has practically no resorptive effect. Does not relieve bronchospasm. The therapeutic effect develops gradually, usually after 5-7 days of course use.

Increases the number of active ?-adrenergic receptors, neutralizes their desensitization, restores the patient's response to bronchodilators, allowing to reduce the frequency of their use.

Indications of the active substances of the drug Beclomethasone

Basic therapy of various forms of bronchial asthma in adults and children over 4 years old.

Dosage regimen

The method of application and dosage regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. It is necessary to strictly observe the compliance of the used dosage form of a particular drug with the indications for use and the dosage regimen. Beclomethasone is used regularly (even in the absence of symptoms).

The dose and treatment regimen depends on the age, the severity of the course of bronchial asthma, the clinical effect in each case.

For inhalation administration of beclomentazone dipropionate, special inhalation devices can be used (in accordance with the dosage form used).

Adults and children aged 12 years and older: The daily dose is 200-2000 mcg.

Children aged 4 to 12 years: The daily dose is 100-400 mcg.

Side effect

Infections: very often - candidiasis of the mouth and pharynx. Using a spacer and rinsing your mouth and throat with water after inhalation reduces the likelihood of these side effects.

From the immune system: infrequently - skin reactions of hypersensitivity, including rash, urticaria, itching, redness and swelling of the eyes, face, lips and mucous membrane of the mouth and pharynx; very rarely - angioedema, anaphylactic reactions.

From the endocrine system: very rarely - systemic effects (suppression of the function of the adrenal cortex, delayed osta in children and adolescents, cataract glaucoma)

From the respiratory system: often - dysphonia (hoarseness) or irritation of the pharyngeal mucosa; very rarely - paradoxical bronchospasm, which must be stopped immediately with the help of an inhaled beta2-adrenostimulator of short action. In the event of paradoxical bronchospasm, it is necessary to immediately stop inhalation use, assess the patient's condition, conduct the necessary examination and prescribe the necessary treatment.

On the part of the skin and subcutaneous fat: often - bruising, thinning of the skin.

Contraindications for use

Tuberculosis (active and inactive); children under 4 years of age; children and adolescents up to 18 years of age (for dosage forms containing 250 mcg of beclomethasone in 1 dose); hypersensitivity to beclomethasone.

Carefully

Glaucoma; systemic infections (bacterial, viral, fungal, parasitic); osteoporosis; cirrhosis of the liver; hypothyroidism; pregnancy; lactation period (breastfeeding).

Application during pregnancy and lactation

Contraindicated in the first trimester of pregnancy.

Application in the II and III trimesters of pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus. Newborns whose mothers received beclomethasone during pregnancy should be carefully evaluated for adrenal insufficiency.

If necessary, use during lactation should decide on the termination of breastfeeding.

Application in children

Preparations for inhalation use containing 250 mcg of beclomethasone in 1 dose are not intended for children under 12 years of age. When administered by inhalation for children, a single dose is 50-100 mcg, the frequency of application is 2-4 times / day. Special instructions Beclomethasone is not intended for the relief of acute asthmatic attacks. It should also not be used for severe attacks of bronchial asthma requiring intensive care. The recommended route of administration for the dosage form used should be strictly observed.

Beclomethasone should be used with extreme caution and under close medical supervision in patients with adrenal insufficiency.

Transfer of patients who are constantly taking GCS inside to inhalation forms can only be done in a stable state.

If paradoxical bronchospasm is likely to develop, bronchodilators (for example, salbutamol) are inhaled 10-15 minutes before the administration of beclomethasone.

With the development of candidiasis of the oral cavity and upper respiratory tract, local antifungal therapy is indicated without stopping treatment with beclomethasone. Infectious and inflammatory diseases of the nasal cavity and paranasal sinuses, with the appointment of appropriate therapy, are not a contraindication for treatment with beclomethasone.

Preparations for inhalation use containing 250 mcg of beclomethasone in 1 dose are not intended for children under 12 years of age.

Drug interactions

Beta-agonists - beclomethasone enhances the effect of beta-agonists. Beclomethasone restores the patient's response to beta-adrenergic agonists, making it possible to reduce the frequency of their use.

Microsomal oxidation inducers (including phenobarbital, phenytoin, rifampicin) - a decrease in the effectiveness of beclomethasone is possible.

Methandienone, estrogens, beta2-adrenergic agonists, theophylline, systemic corticosteroids - strengthening the effects of beclomethasone.