Azitronite 100ml

DESCRIPTION

Azitronit (Azithronit) - the first highly effective safe antibiotic based on azithromycin for the treatment and metaphylaxis of respiratory, gastrointestinal and other animal infections. In appearance, Azitronite is a clear liquid from colorless to yellow.

COMPOSITION

Azitronite in 1 ml contains azithromycin (in the form of a dihydrate) -100 mg as an active ingredient, as well as auxiliary substances: propylene glycol, sodium citrate, benzyl alcohol; citric acid and water for injection up to 1 ml.

PHARMACOLOGICAL PROPERTIES

Azitronite is a macrolide antibacterial drug.

Azithromycin, which is part of Azitronite, is an antibiotic of the macrolide group, a subgroup of azalides, with a broad spectrum of action, which has a bactericidal / bacteriostatic effect on gram-negative (Actinobacillus lignieresi, Haemophilus spp, Moraxella spp, Bordetella spp, Campylobacter spp, Legionella neumophila) and gram-positive bacteria ((Listeria spp, Staphylococcus aureus, Staphylococcus spp, Streptococcus spp, Streptococcus pneumoniae, Streptococcus pyogenes, Enterococcus faecalis, Erysipelothrix insidiosa, and non-anaerobic Fridaemia spp. multocida, Haemophilus parasuis, mycoplasma (Mycoplasma pneumoniae), Chlamydia pneumoniae, spirochetes (Borrelia spp.).

The mechanism of action of azithromycin is associated with inhibition of protein biosynthesis by the ribosomes of bacteria (the formation of peptide bonds between amino acids and the peptide chain is disrupted).

Azithromycin exhibits a postantibiotic effect - persistent inhibition of the vital activity of bacteria after their short-term contact with an antibacterial drug. The effect is based on irreversible changes in the ribosomes of the microorganism, resulting in a persistent block of translocation. Due to this, the general antibacterial effect of the drug is enhanced and prolonged, remaining for the period necessary for the resynthesis of new functional proteins of the microbial cell.

Azithromycin is well absorbed and rapidly distributed in body tissues, reaching high concentrations, many times higher than the concentration in blood plasma. High antimicrobial activity is also provided due to the ability of azithromycin to penetrate and accumulate intracellularly in leukocytes (rranulocytes and monocytes / macrophages), with which it is transported to the foci of inflammation, as a result of which the concentration of the antibiotic is 6 times higher in the focus of inflammation compared to intact tissues.

Azitronite, according to the degree of impact on the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).

DOSAGE AND APPLICATION

Azitronite is used in cattle, sheep and pigs for the treatment of bacterial infections of the respiratory, digestive and genitourinary systems, as well as infections of the skin and soft tissues caused by microorganisms sensitive to azithromycin, for the treatment of necrobacteriosis, swine erysipelas, spirochetosis and mycoplasma infections.

Azitronite is administered intramuscularly to cattle, sheep and pigs at a dose of 1 ml per 20 kg of animal weight (5 mg of azithromycin per 1 kg of animal weight) once a day for 2 days. Repeat the injection if necessary.

SPECIAL INSTRUCTIONS

Overdose symptoms: anxiety, sleep disturbances, disorientation, temporary hearing loss, increased liver enzymes. In this case, it is necessary to stop the drug administration. There are no specific detoxification agents, general measures are used to remove the drug from the body and symptomatic therapy.

The peculiarities of the action during the first use and upon discontinuation of the drug were not revealed.

Slaughter for meat of cattle is carried out no earlier than 40 days, pigs - after 40 days, sheep - 3-5 days after the last injection of the drug. The meat of animals that were forcedly killed before the expiration of the specified period can be used for feeding fur-bearing animals.

CONTRAINDICATIONS

The use of the drug in animals with renal and hepatic insufficiency, as well as hypersensitivity to macrolide antibiotics, is prohibited.

The use of the drug by lactating animals is prohibited, the use of pregnant animals and young animals is allowed with caution, under the supervision of a veterinarian.

SIDE EFFECTS

When using the drug according to the instructions for use, side effects and complications were not established. There may be swelling at the injection site, which quickly passes and does not require treatment. If a persistent allergic reaction occurs, the drug is canceled, antihistamine and symptomatic therapy is recommended.

SHELF LIFE AND STORAGE

The shelf life of the drug, subject to storage conditions, is 2 years from the date of production. After the first opening of the packaging, the medicinal product must be used within 30 days. The medicinal product is stored in the manufacturer's closed packaging, separately from food and feed, in a dry, dark place, at a temperature of 5 В° C to 25 В° C.

PACKAGING

The medicinal product is produced packaged in 100 ml in glass bottles, sealed with rubber stoppers with aluminum caps and clips for first opening control. Vials with the drug in a volume of 100 ml are packed in individual cardboard boxes. Each consumer packaging is supplied with instructions for use.

Specifications

Bonus points

0

KolVUP

50

Manufacturer

Nita-Farm

Temperature regime

from +5 to +25

Teaser

for the treatment of bacterial infections in cattle, sheep and pigs