Azithromycin tablets 500mg, No. 3

Infectious and inflammatory diseases caused by microorganisms sensitive to azithromycin:

Х Infections of the upper respiratory tract and ENT organs (pharyngitis, tonsillitis, sinusitis, otitis media);

Х Lower respiratory tract infections (acute bronchitis, exacerbation of chronic bronchitis, pneumonia, including those caused by atypical pathogens);

Х Infections of the skin and soft tissues (acne vulgaris of moderate severity, erysipelas, impetigo, secondarily infected dermatoses);

Х The initial stage of Lyme disease (borreliosis) - erythema migrans (erythema migrans);

Х Uncomplicated urinary tract infections caused by

Inside, without chewing, 1 time per day, at least 1 hour before or 2 hours after meals.

Adults and children over 12 years of age weighing over 45 kg.

For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues: 500 mg once a day for 3 days (course dose 1.5 g).

The initial stage of Lyme disease: 1 time per day for 5 days: 1st day -1000 mg, then from 2nd to 5th day - 500 mg each (course dose 3.0 g).

For urinary tract infections caused by Chlamydia trachomatis (urethritis, cervicitis): uncomplicated urethritis / cervicitis -1000 mg once.

Acne vulgaris of moderate severity: the course dose is 6 g: 500 mg once a day for 3 days, then 500 mg once a week for 9 weeks.

The first weekly tablet should be taken 7 days after taking the first daily tablet (8th day from the start of treatment), the next 8 weekly tablets should be taken at intervals of 7 days.

Children aged 3 to 12 years with a body weight of less than 45 kg.

For infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues: at the rate of 10 mg / kg body weight 1 time per day for 3 days (course dose 30 mg / kg).

1 tablet contains active ingredient:

1 tablet of 500 mg contains the active substance: azithromycin dihydrate - 531.00 mg, in terms of azithromycin 500.00 mg.

• Hypersensitivity to azithromycin, other macrolides or ketolides, or other components of the drug;

• severe liver dysfunction (Child-Pugh class C);

• severe renal dysfunction (CC less than 40 ml / min);

• children under 12 years of age with a body weight of less than 45 kg (for tablets of 500 mg);

• children under 3 years of age (for tablets 125 mg);

• breastfeeding period;

• simultaneous reception with ergotamine and dihydroergotamine.

pharmachologic effect

Azithromycin is a broad-spectrum bacteriostatic antibiotic from the group of macrolides-azalides. Possesses a wide spectrum of antimicrobial action. The mechanism of action of azithromycin is associated with the suppression of protein synthesis of the microbial cell. By binding to the 50S-subunit of ribosomes of bacterial cells, it inhibits peptide translocase at the translation stage and suppresses protein synthesis, slowing down the growth and reproduction of bacteria. In high concentrations, it has a bactericidal effect. Has activity against a number of gram-positive, gram-negative anaerobic, intracellular and other microorganisms. Microorganisms may initially be resistant to antibiotic action or may acquire resistance to it. Sensitive: aerobic gram-positive microorganisms - Staphylococcus aureus (methicillin-sensitive), Steptococcus pneumophila,Moraxella catarrhalis, Pasteurella multocida, Neisseria gonorrhoeae; anaerobic microorganisms - Clostridium perfringens, Fusobacterium spp., Porphyromonas spp .; others - Chlamidia psittaci, Mycoplasma pneumoniae, Mycoplasma hominis, Borrelia burgodorferi. Microorganisms capable of developing resistance to azithromycin: gram-positive aerobes - Steptococcus pneumoniae (penicillin-resistant strains). Microorganisms with natural resistance: gram-positive aerobes - Enterococcus faecalis, Staphylococcus spp. (methicillin-resistant strains); anaerobes - Bacteroides fragilis. Cases of cross-resistance of Steptococcus pneumoniae, Steptococcus pyogenes (beta-hemolytic group A streptococcus), Enterococcus faecalis and Staphylococcus aureus, including Staphylococcus aureus (methicillin-resistant strains) to erythromycin, azithromycin,other macrolides and lincosamides.

Application during pregnancy and lactation

Azithromycin crosses the placental barrier.

Use during pregnancy is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. If it is necessary to use azithromycin during lactation, the question of stopping breastfeeding should be resolved.

Application for violations of liver function

Not recommended for use in patients with impaired liver function.

Application for impaired renal function

Use with caution in case of impaired renal function.

Application in children

Application is possible according to the dosage regimen.