Azelik gel 15%, 5 g

Acne (acne vulgaris), rosacea.

Outwardly. The gel should be applied to previously thoroughly washed (with water or cleansed with a mild cosmetic cleansing agent) and dried face skin. The gel is applied in a thin layer on the affected skin 2 times / day (morning and evening) and rubbed lightly. Approximately 2.5 cm of gel is sufficient for the entire face. In patients with acne vulgaris, a marked improvement is usually observed after 4 weeks. For best results, use of the drug should be continued for several months.

100 g of gel contain:
active substance: azelaic acid in terms of 100% substance - 15 g;
excipients: benzoic acid 0.1 g, methylpyrrolidone 4 g, squalane 1 g, propylene glycol 8 g, disodium edetate 0.1 g, sodium hydroxide 0.25 g, dimethicone 1 g, macrogol cetostearate 1.4 g, carbomer interpolymer 1 , 4 g, purified water up to 100 g.

Hypersensitivity to the components of the drug.

With care
Pregnancy, lactation.

Trade name of the drug: AzelikЃ

International non-proprietary name:

azelaic acid

Dosage form:

gel for external use

Composition
100 g of gel contains:
active substance: azelaic acid in terms of 100% substance - 15 g;
excipients: benzoic acid 0.1 g, methylpyrrolidone 4 g, squalane 1 g, propylene glycol 8 g, disodium edetate 0.1 g, sodium hydroxide 0.25 g, dimethicone 1 g, macrogol cetostearate 1.4 g, carbomer interpolymer 1 , 4 g, purified water up to 100 g.

Description The
gel is white or almost white in color, the presence of a weak specific odor is allowed.

Pharmacotherapeutic group:

acne rash treatment

ATX code: D10AX03

Pharmacological properties
Pharmacodynamics
Possesses bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis , reduces the production of fatty acids that contribute to acne. Reduces the formation of comedones. Influencing the process of keratinization of epidermal cells, it inhibits the growth and activity of abnormal melanocytes that cause hyperpigmentation such as melasma. It has anti-acne, depigmenting effect.

Pharmacokinetics
After application to the skin, it penetrates the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic circulation. Part of the absorbed acid is excreted by the kidneys unchanged, part - in the form of dicarboxylic acids (C7, C5), formed as a result of beta-oxidation.

Indications for use
Acne (acne vulgaris), rosacea.

Contraindications
Hypersensitivity to the components of the drug.

With care
Pregnancy, lactation.

Application during pregnancy and during breastfeeding
During pregnancy and during breastfeeding, it is used only if the intended benefit to the mother outweighs the risk to the fetus and child.

Method of administration and dosage
Outwardly. The gel should be applied to previously thoroughly washed (with water or cleansed with a mild cosmetic cleansing agent) and dried face skin. The gel is applied in a thin layer to the affected skin 2 times / day (morning and evening) and rubbed lightly. Approximately 2.5 cm of gel is sufficient for the entire face. In patients with acne vulgaris, a marked improvement is usually observed after 4 weeks. For best results, use of the drug should be continued for several months.

Side effect
At the beginning of treatment, there may be a local irritating effect, flushing and peeling of the skin, burning, erythema, itching, which usually stop during treatment. Allergic skin reactions are possible.

Overdose
Currently, no cases of drug overdose have been described.

Interaction with other drugs
Can be used in combination with other drugs for the treatment of acne.

Special instructions
Avoid getting the drug in the eyes, as well as on the mucous membranes of the nose, lips and mouth, in case of accidental contact, rinse immediately with water.
In cases of severe skin irritation in the first weeks of treatment, the gel can be applied 1 time / day; a short-term withdrawal of the drug is also possible. After the symptoms of skin irritation disappear, regular use of the drug should be resumed at the recommended dose.
During treatment, it is necessary to protect the skin from the entire spectrum of solar radiation.

Release form
Gel for external use 15%.
5 or 30 g in an aluminum tube. Each tube, together with instructions for use, in a cardboard box.

Storage conditions
At a temperature not exceeding 25 ? —. Do not freeze.
Keep out of the reach of children.

Shelf life is
2 years.
Do not use after the expiration date.

Terms of dispensing from pharmacies
Without prescription.