Atsetylsalytsylovaya acid, caffeine, paracetamol | Excedrine tablets, 20 pcs.
Special Price
$20.37
Regular Price
$29.00
In stock
SKU
BID494980
Product Overview
Excedrine is a non-prescription drug in the form of tablets that is intended to relieve migraines.
Excedrine has a threefold effect: acetylsalicylic acid and paracetamol relieve headache, and caffeine enhances the effect of the combination. *, ** in addition, Excedrine helps relieve concomitant migraine symptoms such as nausea and hypersensitivity to light and sound. *
Excedrine helps relieve pain and other migraine symptoms within 30 minutes! *
* Richard B. Lipton, MD Walter F. Stewart, PhD, MPH Robert E. Ryan, Jr, MD Joel Saper, MD Stephen Silberstein, MD Fred Sheftell, MD. ARCH NEUROL / VOL 55, FEB 1998
** Instructions for medical use, RU Рџ N009980
Excedrine is a non-prescription drug in the form of tablets that is intended to relieve migraines.
Excedrine has a threefold effect: acetylsalicylic acid and paracetamol relieve headache, and caffeine enhances the effect of the combination. *, ** in addition, Excedrine helps relieve concomitant migraine symptoms such as nausea and hypersensitivity to light and sound. *
Excedrine helps relieve pain and other migraine symptoms within 30 minutes! *
* Richard B. Lipton, MD Walter F. Stewart, PhD, MPH Robert E. Ryan, Jr, MD Joel Saper, MD Stephen Silberstein, MD Fred Sheftell, MD. ARCH NEUROL / VOL 55, FEB 1998
** Instructions for medical use, RU Рџ N009980
Product Overview
Excedrine is a non-prescription drug in the form of tablets that is intended to relieve migraines.
Excedrine has a threefold effect: acetylsalicylic acid and paracetamol relieve headache, and caffeine enhances the effect of the combination. *, ** in addition, Excedrine helps relieve concomitant migraine symptoms such as nausea and hypersensitivity to light and sound. *
Excedrine helps relieve pain and other migraine symptoms within 30 minutes! *
* Richard B. Lipton, MD Walter F. Stewart, PhD, MPH Robert E. Ryan, Jr, MD Joel Saper, MD Stephen Silberstein, MD Fred Sheftell, MD. ARCH NEUROL / VOL 55, FEB 1998
** Instructions for medical use, RU Рџ N009980
Description
White film-coated tablets, oblong, with E engraving on one side, a cross-sectional view is the core of white or almost white.
Latin name
Coldrexff49f796frefffffrin6fref4f496freffrffrfffrffrffrffrf4 f Latin name
Exedrin
Release form
Film-coated tablets
Pharmacological action
ExcedrineВ® is a combined preparation containing paracetamol, acetylsalicylic acid and caffeine.
Paracetamol has pain medication, antipyretic and extremely weak anti-inflammatory effect, which is associated with its effect on the center of thermoregulation in the hypothalamus and mild ability to inhibit the synthesis of prostaglandins in peripheral tissues.
Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. It quickly relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and slows the process of thrombosis, improving microcirculation in the focus of inflammation.
Caffeine increases the reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates the blood vessels of the skeletal muscles, brain, heart, kidneys, and reduces platelet aggregation. Reduces drowsiness, fatigue, increases mental and physical performance.
Indications
Medium and light intensity pain syndrome of various origins: headache migraine toothache neuralgia arthralgia and myalgia (pain in muscles and joints) algodismenorrhea (pain during menstruation).
Contraindications
Hypersensitivity to any of the components of the preparation erosive-ulcerative lesions of the gastrointestinal tract in the acute phase of gastrointestinal bleeding, complete or incomplete combination of bronchial asthma, recurrent polypnosis of the nose and paranasal sinuses and non-acetyl salicylic salivary drugs. including history) surgical interventions accompanied by bleeding hemophilia hemorrhagic diathesis hypoprothrombinemia severe artery lax hypertension portal hypertension severe course of coronary heart disease glaucoma vitamin deficiency K renal failure simultaneous use of other drugs containing paracetamol, acetylsalicylic acid or another non-steroidal anti-inflammatory drug glucose-6-phosphate dehydrogenase deficiency pregnancy lactation increased irritability sleep disturbances children under 15 years of age (risk of developing Reye's syndrome in children with hyperthermia due to viral diseases).
Use caution with gout, liver disease, headaches associated with head trauma, taking anticoagulants, hypoglycemic agents, gout or arthritis, as well as taking medications containing acetylsalicylic acid or other painkillers and antipyretic drugs.
Use during pregnancy and lactation
Despite the fact that acetylsalicylic acid can be used in the second trimester of pregnancy, the safety of this combination in pregnant and lactating women has not been studied, therefore, the drug is contraindicated in pregnant women (in all trimesters) and breast-feeding.
Special instructions
If symptoms persist, worsen, or new symptoms occur after taking the drug, you should immediately consult a doctor.
upon reception deterioration is observed or new symptoms occur, you should immediately consult a doctor.
upon reception deterioration is observed or new symptoms occur, you should immediately consult a doctor.
upon receptionIn the recommended dose, the same amount of caffeine enters the body as is contained in one cup of coffee, so you should reduce the consumption of caffeinated products during treatment with this drug in order to avoid the development of nervous excitement, irritability, insomnia and heart palpitations against the background of an overdose of caffeine.
If you suspect an overdose, you should immediately seek medical help, even if there are no symptoms. You should refrain from drinking alcohol while taking the drug due to the increased risk of liver damage and gastrointestinal bleeding.
Since acetylsalicylic acid slows down blood coagulation, the patient who is to undergo surgery should warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid, and therefore, in patients with a predisposition, the drug can provoke an attack of gout. With prolonged use of the drug, control of peripheral blood and the functional state of the liver is necessary.
Impact on the ability to drive vehicles and work with mechanisms
No information was reported on the effect of the drug on the ability to drive a car and work with mechanisms.
Composition
1 tablet contains 250 mg paracetamol,
acetylsalicylic acid 250 mg,
caffeine 65 mg
Dosage and administration of
The drug is taken orally during or after a meal.
Adults and teenagers from 15 years of age: 1 tablet every 4-6 hours.
At the first sign of migraine, take 2 tablets.
The average daily dose is 3-4 tablets per day, the maximum daily dose is 6 tablets per day.
After taking 2 tablets, relief of headache and other types of pain usually occurs quickly - after 15 minutes, with migraines, relief usually occurs after 30 minutes.
In case of pain, the drug should not be taken for more than 5 days without consulting a doctor. In case of migraine, the drug should not be taken for more than 3 days without consulting a doctor.
Side effects
Gastralgia, nausea, vomiting, hepatotoxicity, nephrotoxicity, erosive ulcerative lesions of the gastrointestinal tract, allergic reactions, tachycardia, increased blood pressure, bronchospasm.
With prolonged use - dizziness, headache, visual impairment, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nasal bleeding, bleeding gums, purpura, etc.), kidney damage with papillary necrosis, deafness, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), Reye's syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system, psoriasis, psoriasis) .
Drug Interaction
Drug may enhance the action of heparin, indirect coagulants, reserpine, steroid hormones and hypoglycemic drugs.
Co-administered with other NSAIDs, methotrexate increases the risk of side effects. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-gout drugs that promote uric acid.
Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other inducers of microsomal liver enzymes contribute to the formation of toxic metabolites of paracetamol affecting liver function. Metoclopramide accelerates the absorption of paracetamol.
Under the influence of paracetamol, the elimination half-life of chloramphenicol is increased 5-fold. Re-administration of paracetamol may enhance the action of anticoagulants (coumarin derivatives).
Concurrent administration of paracetamol, acetylsalicylic acid and alcoholic beverages increase the risk of hepatotoxic effects. Caffeine accelerates the absorption of ergotamine.
Overdose
Symptoms due to the presence of paracetamol (when taken in doses of more than 10-15 g / days): during the first 24 hours, pallor of the skin, nausea, vomiting, anorexia, abdominal pain, impaired glucose metabolism, metabolic acidosis. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In severe overdose, hepatic failure with progressive encephalopathy, coma, death, acute renal failure with tubular necrosis (including in the absence of severe liver damage), arrhythmia, pancreatitis. Hepatotoxic effect in adults manifests itself when taking 10 g or more.
Symptoms due to the presence of acetylsalicylic acid (when taken in doses of more than 150 mg / kg): for mild intoxications - nausea, vomiting, tinnitus, blurred vision, dizziness, severe headache. In severe poisoning - hyperventilation of the lungs of central origin (shortness of breath, suffocation, cyanosis, cold clammy sweat, respiratory paralysis), respiratory acidosis. The greatest risk of chronic intoxication is observed in children and the elderly when taken for several days more than 100 mg / kg / day. With moderate and severe poisoning, hospitalization is necessary.
Symptoms due to the presence of caffeine (when taken in doses of more than 300 mg / day): gastralgia, agitation, anxiety, agitation, motor anxiety, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, increased tactile or pain sensitivity, tremors or muscle twitches nausea and vomiting, sometimes with blood ringing in the ears, epileptic seizures (in acute overdose - tonic-clonic).
Treatment: control of the acid-base state and electrolyte balance. Depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate. Increasing alkalinity enhances the elimination of acetylsalicylic acid by alkalizing urine. Gastric lavage in the first 4 hours, vomiting, taking activated charcoal, laxatives, administration of SH group donors and precursors of glutathione methionine synthesis for 8-9 hours after an overdose and acetylcysteine - for 8 hours
Storage conditions
At a temperature not exceeding 25 РC.
Keep out of the reach and sight of children.
Expiration
3 years. Do not use after the expiry date stated on the packaging.
Effective substance
Acetylsalicylic acid, Caffeine, Paracetamol
Excedrine is a non-prescription drug in the form of tablets that is intended to relieve migraines.
Excedrine has a threefold effect: acetylsalicylic acid and paracetamol relieve headache, and caffeine enhances the effect of the combination. *, ** in addition, Excedrine helps relieve concomitant migraine symptoms such as nausea and hypersensitivity to light and sound. *
Excedrine helps relieve pain and other migraine symptoms within 30 minutes! *
* Richard B. Lipton, MD Walter F. Stewart, PhD, MPH Robert E. Ryan, Jr, MD Joel Saper, MD Stephen Silberstein, MD Fred Sheftell, MD. ARCH NEUROL / VOL 55, FEB 1998
** Instructions for medical use, RU Рџ N009980
Description
White film-coated tablets, oblong, with E engraving on one side, a cross-sectional view is the core of white or almost white.
Latin name
Coldrexff49f796frefffffrin6fref4f496freffrffrfffrffrffrffrf4 f Latin name
Exedrin
Release form
Film-coated tablets
Pharmacological action
ExcedrineВ® is a combined preparation containing paracetamol, acetylsalicylic acid and caffeine.
Paracetamol has pain medication, antipyretic and extremely weak anti-inflammatory effect, which is associated with its effect on the center of thermoregulation in the hypothalamus and mild ability to inhibit the synthesis of prostaglandins in peripheral tissues.
Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. It quickly relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and slows the process of thrombosis, improving microcirculation in the focus of inflammation.
Caffeine increases the reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates the blood vessels of the skeletal muscles, brain, heart, kidneys, and reduces platelet aggregation. Reduces drowsiness, fatigue, increases mental and physical performance.
Indications
Medium and light intensity pain syndrome of various origins: headache migraine toothache neuralgia arthralgia and myalgia (pain in muscles and joints) algodismenorrhea (pain during menstruation).
Contraindications
Hypersensitivity to any of the components of the preparation erosive-ulcerative lesions of the gastrointestinal tract in the acute phase of gastrointestinal bleeding, complete or incomplete combination of bronchial asthma, recurrent polypnosis of the nose and paranasal sinuses and non-acetyl salicylic salivary drugs. including history) surgical interventions accompanied by bleeding hemophilia hemorrhagic diathesis hypoprothrombinemia severe artery lax hypertension portal hypertension severe course of coronary heart disease glaucoma vitamin deficiency K renal failure simultaneous use of other drugs containing paracetamol, acetylsalicylic acid or another non-steroidal anti-inflammatory drug glucose-6-phosphate dehydrogenase deficiency pregnancy lactation increased irritability sleep disturbances children under 15 years of age (risk of developing Reye's syndrome in children with hyperthermia due to viral diseases).
Use caution with gout, liver disease, headaches associated with head trauma, taking anticoagulants, hypoglycemic agents, gout or arthritis, as well as taking medications containing acetylsalicylic acid or other painkillers and antipyretic drugs.
Use during pregnancy and lactation
Despite the fact that acetylsalicylic acid can be used in the second trimester of pregnancy, the safety of this combination in pregnant and lactating women has not been studied, therefore, the drug is contraindicated in pregnant women (in all trimesters) and breast-feeding.
Special instructions
If symptoms persist, worsen, or new symptoms occur after taking the drug, you should immediately consult a doctor.
upon reception deterioration is observed or new symptoms occur, you should immediately consult a doctor.
upon reception deterioration is observed or new symptoms occur, you should immediately consult a doctor.
upon receptionIn the recommended dose, the same amount of caffeine enters the body as is contained in one cup of coffee, so you should reduce the consumption of caffeinated products during treatment with this drug in order to avoid the development of nervous excitement, irritability, insomnia and heart palpitations against the background of an overdose of caffeine.
If you suspect an overdose, you should immediately seek medical help, even if there are no symptoms. You should refrain from drinking alcohol while taking the drug due to the increased risk of liver damage and gastrointestinal bleeding.
Since acetylsalicylic acid slows down blood coagulation, the patient who is to undergo surgery should warn the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid, and therefore, in patients with a predisposition, the drug can provoke an attack of gout. With prolonged use of the drug, control of peripheral blood and the functional state of the liver is necessary.
Impact on the ability to drive vehicles and work with mechanisms
No information was reported on the effect of the drug on the ability to drive a car and work with mechanisms.
Composition
1 tablet contains 250 mg paracetamol,
acetylsalicylic acid 250 mg,
caffeine 65 mg
Dosage and administration of
The drug is taken orally during or after a meal.
Adults and teenagers from 15 years of age: 1 tablet every 4-6 hours.
At the first sign of migraine, take 2 tablets.
The average daily dose is 3-4 tablets per day, the maximum daily dose is 6 tablets per day.
After taking 2 tablets, relief of headache and other types of pain usually occurs quickly - after 15 minutes, with migraines, relief usually occurs after 30 minutes.
In case of pain, the drug should not be taken for more than 5 days without consulting a doctor. In case of migraine, the drug should not be taken for more than 3 days without consulting a doctor.
Side effects
Gastralgia, nausea, vomiting, hepatotoxicity, nephrotoxicity, erosive ulcerative lesions of the gastrointestinal tract, allergic reactions, tachycardia, increased blood pressure, bronchospasm.
With prolonged use - dizziness, headache, visual impairment, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nasal bleeding, bleeding gums, purpura, etc.), kidney damage with papillary necrosis, deafness, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), Reye's syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system, psoriasis, psoriasis) .
Drug Interaction
Drug may enhance the action of heparin, indirect coagulants, reserpine, steroid hormones and hypoglycemic drugs.
Co-administered with other NSAIDs, methotrexate increases the risk of side effects. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-gout drugs that promote uric acid.
Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other inducers of microsomal liver enzymes contribute to the formation of toxic metabolites of paracetamol affecting liver function. Metoclopramide accelerates the absorption of paracetamol.
Under the influence of paracetamol, the elimination half-life of chloramphenicol is increased 5-fold. Re-administration of paracetamol may enhance the action of anticoagulants (coumarin derivatives).
Concurrent administration of paracetamol, acetylsalicylic acid and alcoholic beverages increase the risk of hepatotoxic effects. Caffeine accelerates the absorption of ergotamine.
Overdose
Symptoms due to the presence of paracetamol (when taken in doses of more than 10-15 g / days): during the first 24 hours, pallor of the skin, nausea, vomiting, anorexia, abdominal pain, impaired glucose metabolism, metabolic acidosis. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In severe overdose, hepatic failure with progressive encephalopathy, coma, death, acute renal failure with tubular necrosis (including in the absence of severe liver damage), arrhythmia, pancreatitis. Hepatotoxic effect in adults manifests itself when taking 10 g or more.
Symptoms due to the presence of acetylsalicylic acid (when taken in doses of more than 150 mg / kg): for mild intoxications - nausea, vomiting, tinnitus, blurred vision, dizziness, severe headache. In severe poisoning - hyperventilation of the lungs of central origin (shortness of breath, suffocation, cyanosis, cold clammy sweat, respiratory paralysis), respiratory acidosis. The greatest risk of chronic intoxication is observed in children and the elderly when taken for several days more than 100 mg / kg / day. With moderate and severe poisoning, hospitalization is necessary.
Symptoms due to the presence of caffeine (when taken in doses of more than 300 mg / day): gastralgia, agitation, anxiety, agitation, motor anxiety, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, increased tactile or pain sensitivity, tremors or muscle twitches nausea and vomiting, sometimes with blood ringing in the ears, epileptic seizures (in acute overdose - tonic-clonic).
Treatment: control of the acid-base state and electrolyte balance. Depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate. Increasing alkalinity enhances the elimination of acetylsalicylic acid by alkalizing urine. Gastric lavage in the first 4 hours, vomiting, taking activated charcoal, laxatives, administration of SH group donors and precursors of glutathione methionine synthesis for 8-9 hours after an overdose and acetylcysteine - for 8 hours
Storage conditions
At a temperature not exceeding 25 РC.
Keep out of the reach and sight of children.
Expiration
3 years. Do not use after the expiry date stated on the packaging.
Effective substance
Acetylsalicylic acid, Caffeine, Paracetamol
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