Ascorutin tablets, No. 50 Reneval

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SKU
BIDL3178248
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Expiration Date: 05/2027

Russian Pharmacy name:

Аскорутин таблетки, №50 Реневал

Ascorutin tablets, No. 50 Reneval

Hypo- and vitamin deficiency of ascorbic acid and rutoside.

As part of complex therapy for varicose veins, trophic disorders and skin ulcers, with chronic venous insufficiency; with hemorrhagic diathesis.

Inside.

1 tablet 2-3 times a day during or after meals.

The course of treatment is 2-3 weeks.

If after treatment there is no improvement or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, the route of administration and the doses indicated in the instructions.

Active ingredients:
Ascorbic acid - 50.0 mg
Rutozide trihydrate - 54.4 mg
(in terms of rutoside (rutin)) - 50.0 mg
Excipients:
sucrose - 181.3 mg
potato starch - 38.7 mg
povidone K 30 - 3.5 mg
calcium stearate - 2.1 mg

  • Increased individual sensitivity to the components of the drug;

  • congenital fructose intolerance, glucose-galactose malabsorption, sucrase / isomaltase deficiency;

  • pregnancy (1 trimester);

  • children under 18 years of age.

Carefully

Conditions accompanied by blood hypercoagulation and a tendency to thrombosis, thrombophlebitis, diabetes mellitus.
If you have one of the listed diseases, be sure to consult your doctor before taking the drug.

Trade name:

Ascorutin

International non-proprietary or group name:

ascorbic acid + rutoside

Dosage form:

pills

Composition for one tablet

Active ingredients:
Ascorbic acid - 50.0 mg
Rutozide trihydrate - 54.4 mg
(in terms of rutoside (rutin)) - 50.0 mg
Excipients:
sucrose - 181.3 mg
potato starch - 38.7 mg
povidone K 30 - 3.5 mg
calcium stearate - 2.1 mg

Description

Round flat-cylindrical tablets of light yellow or greenish-yellow color with beveled and scored. The presence of light and dark inclusions is allowed.

Pharmacotherapeutic group:

vitamin.

ATX code:

C05CA51

Pharmacological properties

Pharmacodynamics
Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, and helps to increase the body's resistance.

Rutoside (a derivative of rutin) eliminates increased capillary permeability, strengthens the vascular wall, reducing its swelling and inflammation. It has an angiaggregant effect, which improves microcirculation.

Pharmacokinetics
Ascorbic acid
Absorption
Absorbed in the gastrointestinal tract (GIT), mainly in the jejunum. With an increase in the dose to 200 mg, up to 140 mg (70%) is absorbed, with a further increase in the dose, absorption decreases (50-20%). Communication with plasma proteins - 25%. Diseases of the gastrointestinal tract (peptic ulcer and 12 duodenal ulcer, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbate in the intestine.

Distribution
Plasma concentration of ascorbic acid is normally approximately 10-20 ?g / ml, reserves in the body are about 1.5 g when taking the daily recommended doses and 2.5 g when taking 200 mg / day. TCmax (half-life) after oral administration - 4 hours.
Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; deposited in the posterior lobe of the pituitary gland, adrenal cortex, ocular epithelium, interstitial cells of the seminal glands, ovaries, liver, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland; crosses the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficient conditions, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration.

Metabolism
Metabolized mainly in the liver to deoxyascorbic acid and then to oxaloacetic acid and diketogulonic acid.

Excretion
It is excreted by the kidneys, through the intestines, with sweat, breast milk in the form of unchanged ascorbate and metabolites.
When high doses are prescribed, the rate of elimination increases dramatically. Smoking and consumption of ethanol accelerate the breakdown of ascorbic acid (conversion into inactive metabolites), dramatically reducing body stores. It is excreted during hemodialysis.

Rutozid
Time of maximum concentration in blood plasma after oral administration - 1-9 hours. It is excreted mainly in the bile and to a lesser extent by the kidneys. The half-life is 10-25 hours.

Indications for use

Hypo- and vitamin deficiency of ascorbic acid and rutoside.

As part of complex therapy for varicose veins, trophic disorders and skin ulcers, with chronic venous insufficiency; with hemorrhagic diathesis.

Contraindications

  • Increased individual sensitivity to the components of the drug;

  • congenital fructose intolerance, glucose-galactose malabsorption, sucrase / isomaltase deficiency;

  • pregnancy (1 trimester);

  • children under 18 years of age.

Carefully

Conditions accompanied by blood hypercoagulation and a tendency to thrombosis, thrombophlebitis, diabetes mellitus.
If you have one of the listed diseases, be sure to consult your doctor before taking the drug.

Application during pregnancy and during breastfeeding

Due to the rutin content in the preparation, it should not be used in the 1st trimester of pregnancy.
When using the drug during pregnancy (II-III trimesters) and during breastfeeding, the dosage and duration of the course prescribed by the doctor must be observed.

Method of administration and dosage

Inside.

1 tablet 2-3 times a day during or after meals.

The course of treatment is 2-3 weeks.

If after treatment there is no improvement or symptoms worsen, or new symptoms appear, you should consult your doctor.

Use the drug only according to the indications, the route of administration and the doses indicated in the instructions.

Side effect

Allergic reactions (skin rash), dyspeptic disorders, headache are possible.

It is important to report the development of adverse reactions in order to ensure continuous monitoring of the relationship between the benefits and risks of the drug. If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects that are not indicated in the instructions, inform your doctor. Health care providers report adverse drug reactions through national ADR systems.

Overdose

Symptoms: excessive use of the drug can cause nausea, vomiting, diarrhea, headache.
Treatment: symptomatic, forced diuresis.
In case of drug overdose, you should immediately consult a doctor.

Interaction with other medicinal products

Ascorbic acid increases the absorption of drugs of the penicillin group, iron; reduces the clinical effect of heparin and indirect anticoagulants, which requires dose adjustment when used simultaneously.
If you are using the above or other drugs (including over-the-counter), consult your doctor before using Ascorutin.

special instructions

Patients with diabetes mellitus should take into account that one tablet of the drug contains about 0.2 g of carbohydrates (0.017 XE).
When using the drug alone, it is recommended not to exceed the maximum periods and recommended doses.
If there is no decrease or worsening of the symptoms of the disease, it is recommended to consult a doctor.

Influence on the ability to drive vehicles, mechanisms

The use of the drug does not affect the ability to perform potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (driving, working with moving mechanisms).

Release form

Tablets, 50 mg + 50 mg.
On 10 tablets in a blister strip packaging from a film of polyvinyl chloride and printed aluminum foil varnished.
5 blister packs of 10 tablets with instructions for use are placed in a cardboard box for consumer packaging.

Storage conditions

At a temperature not exceeding 25 ? — in a pack.
Keep out of the reach of children.

Shelf life

3 years.
Do not use after the expiration date.

Vacation conditions

Available without a prescription.

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