Arbidol Maximum capsule 200mg, No. 10

• Prevention and treatment in adults and children from 12 years of age: influenza A and B, ARVI (including those complicated by bronchitis, pneumonia), severe acute respiratory syndrome (SARS);

• complex therapy of acute intestinal infections of rotavirus etiology in children over 12 years old;

• complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection;

• prevention of postoperative infectious complications.

Inside, before meals. Single dose for adults and children over 12 years old - 200 mg (1 capsule).

For non-specific prevention and treatment of influenza and other acute respiratory viral infections

Non-specific prevention of influenza and other acute respiratory viral infections

- during an epidemic of influenza and other acute respiratory viral infections - 200 mg (1 capsule) 2 times a week for 3 weeks;

- in direct contact with patients with influenza and other acute respiratory viral infections - 200 mg (1 capsule) 1 time per day for 10-14 days.

Treatment of influenza and other acute respiratory viral infections

- with uncomplicated course - 200 mg (1 capsule) 4 times a day (every 6 hours) for 5 days;

- with the development of complications (bronchitis, pneumonia, etc.) - 200 mg (1 capsule) 4 times a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks.

Complex therapy of acute intestinal infections of rotavirus etiology in children over 12 years old - 200 mg (1 capsule) 4 times a day (every 6 hours) for 5 days.

For non-specific prophylaxis and treatment of severe acute respiratory syndrome (SARS)

- nonspecific prophylaxis of SARS (in contact with a patient) - 200 mg (1 capsule) 1 time per day for 12-14 days;

- SARS treatment - 200 mg (1 caps.) 2 times a day for 8-10 days.

In the complex therapy of chronic bronchitis, pneumonia and herpes infection - 200 mg (1 capsule) 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks.

Prevention of postoperative complications - 200 mg (1 capsule) for 2 days. before the operation, then on the 2nd and 5th days after the operation.

Hard gelatin capsules, size No. 0, white; contents of capsules - a mixture containing granules and powder from white or white with a greenish-yellow or cream shade of color to light yellow or light yellow with a greenish shade.

1 caps.

umifenovir hydrochloride (as umifenovir hydrochloride monohydrate) 200 mg

Excipients: potato starch - 52.67 mg, microcrystalline cellulose - 11.2 mg, colloidal silicon dioxide (aerosil) - 2.8 mg, povidone (Kollidon 25) - 7.73 mg, calcium stearate - 2.8 mg, croscarmellose sodium - 2.8 mg; the mass of the contents of the capsule is 280 mg.

• Hypersensitivity to the drug;

• children under 12 years of age.

pharmachologic effect

ѕротивовирусный препарат. —пецифически подавл¤ет in vitro вирусы гриппа ј и ¬ (Influenza virus ј, ¬), включа¤ высокопатогенные подтипы A(H1N1)pdm09 и A(H5N1), а также другие вирусы - возбудители ќ–¬» (коронавирус (Coronavirus), ассоциированный с т¤желым острым респираторным синдромом (“ќ–—), риновирус (Rhinovirus), аденовирус (Adenovirus), респираторно-синцитиальный вирус (Pneumovirus) и вирус парагриппа (Paramyxovirus)). ѕо механизму противовирусного действи¤ относитс¤ к ингибиторам сли¤ни¤ (фузии), взаимодействует с гемагглютинином вируса и преп¤тствует сли¤нию липидной оболочки вируса и клеточных мембран. ќказывает умеренное иммуномодулирующее действие, повышает устойчивость организма к вирусным инфекци¤м. ќбладает интерферон-индуцирующей активностью - в исследовании на мышах индукци¤ интерферонов отмечалась уже через 16 ч, а высокие титры интерферонов сохран¤лись в крови до 48 ч после введени¤. —тимулирует клеточные и гуморальные реакции иммунитета: повышает число лимфоцитов в крови, в особенности “-клеток (CD3), повышает число “-хелперов (CD4), не вл褤 на уровень “-супрессоров (CD8), нормализует иммунорегул¤торный индекс, стимулирует фагоцитарную функцию макрофагов и повышает число естественных киллеров (NK-клеток).

Therapeutic efficacy in viral infections is manifested in a decrease in the duration and severity of the course of the disease and its main symptoms, as well as in a decrease in the incidence of complications associated with a viral infection and exacerbations of chronic bacterial diseases.

Refers to low-toxic drugs (LD50> 4 g / kg). Does not have any negative effect on the human body when taken orally in recommended doses.

Pharmacokinetics

Absorption and distribution

It is rapidly absorbed and distributed to organs and tissues. Cmax in blood plasma when taken at a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours.

Metabolism and excretion

It is metabolized in the liver.

T1 / 2 is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in a small amount by the kidneys (0.12%). During the first day, 90% of the administered dose is excreted.

Side effect

Rarely: allergic reactions.

Application during pregnancy and lactation

In animal studies, no harmful effects on the course of pregnancy, embryo and fetal development, labor and postnatal development have been identified.

The use of the drug ArbidolЃ Maximum in the first trimester of pregnancy is contraindicated.

In the II and III trimesters of pregnancy, ArbidolЃ Maximum can be used only for the treatment and prevention of influenza and if the intended benefit to the mother outweighs the potential risk to the fetus. The benefit / risk ratio is determined by the attending physician.

It is not known whether ArbidolЃ Maximum is excreted in breast milk in women during lactation. If you need to use the drug ArbidolЃ Maximum, you should stop breastfeeding.

Application in children

The drug is contraindicated for use in children under 12 years of age.

special instructions

Influence on the ability to drive vehicles and mechanisms

It does not show central neurotropic activity and can be used in medical practice in people of various professions requiring increased attention and coordination of movements (including transport drivers, operators).

Overdose

There were no cases of drug overdose.

Drug interactions

When administered with other drugs, no negative effects were noted.