Arbidol capsules 100mg, No. 20

Prevention and treatment in adults and children:
- influenza A and B, ARVI, severe acute respiratory syndrome (SARS) (including those complicated by bronchitis, pneumonia);
- secondary immunodeficiency states;
- complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection.
Prevention of postoperative infectious complications and normalization of the immune status.
Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years old.

Inside, before meals. Single dose: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg).

For non-specific prophylaxis:
In direct contact with patients with influenza and other acute respiratory viral infections:
- children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg once a day for 10- 14 days.
During an epidemic of influenza and other acute respiratory viral infections, to prevent exacerbations of chronic bronchitis, recurrence of herpes infection:
- children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg twice a week within 3 weeks.
For the prevention of SARS (in contact with a patient):
- adults and children over 12 years of age are prescribed 200 mg once a day. Children from 6 to 12 years old, 100 mg once a day (before meals) for 12-14 days.
Prevention of postoperative complications:
- children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 2 days before surgery, then 2 and 5 days after surgery.

For treatment:
Influenza, other acute respiratory viral infections without complications:
- children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days.
Influenza, other acute respiratory viral infections with the development of complications (bronchitis, pneumonia, etc.):
- children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose once a week for 4 weeks.
Severe acute respiratory syndrome (SARS):
- children over 12 years old and adults - 200 mg 2 times a day for 8-10 days.
In the complex treatment of chronic bronchitis, herpes infection:
- children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks.
Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years old:
- from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old - 200 mg 4 times a day (every 6 hours) for 5 days.

Active ingredient:
umifenovir (umifenovir hydrochloride monohydrate (arbidol) in terms of umifenovir hydrochloride) - 100 mg
Excipients:
potato starch - 30.14 mg, microcrystalline cellulose - 55.76 mg, colloidal silicon dioxide (aerosil) - 2.0 mg , povidone (kollidone 25) - 10.1 mg, calcium stearate - 2.0 mg.
Hard gelatin capsules:
titanium dioxide (E 171), quinoline yellow (E 104), sunset yellow dye (E110), methyl parahydroxybenzoate, propyl parahydroxybenzoate, acetic acid, gelatin.
Or hard gelatin capsules:
titanium dioxide (E 171), quinoline yellow (E 104), sunset yellow dye (E 110), gelatin.

• Hypersensitivity to the drug,

• age up to 6 years (for a dosage of 100 mg)

• pregnancy

• lactation period.

Pharmacological properties:

Pharmacodynamics .

Antiviral agent. Specifically inhibits influenza A and B viruses, coronavirus associated with severe acute respiratory syndrome (SARS). According to the mechanism of antiviral action, it belongs to fusion inhibitors (fusion), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid membrane of the virus and cell membranes. Has a moderate immunomodulatory effect. It has interferon-inducing activity, stimulates humoral and cellular immune responses, phagocytic function of macrophages, increases the body's resistance to viral infections. Reduces the incidence of complications associated with a viral infection, as well as exacerbations of chronic bacterial diseases.
Therapeutic efficacy in viral infections is manifested in a decrease in the severity of general intoxication and clinical phenomena, and a reduction in the duration of the disease.
Refers to low-toxic drugs (LD50> 4 g / kg). Does not have any negative effects on the human body when taken orally in recommended doses.

Pharmacokinetics .

It is rapidly absorbed and distributed to organs and tissues. The maximum concentration in blood plasma when taken at a dose of 50 mg is achieved after 1.2 hours, at a dose of 100 mg - after 1.5 hours. It is metabolized in the liver. The half-life is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in a small amount by the kidneys (0.12%). During the first day, 90% of the administered dose is excreted.

Side effects:

Rarely - allergic reactions.

Overdose:

Not checked.

Interaction with other medicinal products:

When administered with other drugs, no negative effects were noted.

Special instructions:

It does not show central neurotropic activity and can be used in medical practice for prophylactic purposes in practically healthy individuals of various professions, incl. requiring increased attention and coordination of movements (transport drivers, operators, etc.).