AnviMax pores. d / prigot. r-ra d / int. taking 5g sachet # 6 (black currant)

Special Price $13.30 Regular Price $20.00
In stock
SKU
OTC10201748

Package quantity, pcs:

3

6

12

24

Category

Pain and fever

Scope of the drug

General

Release form

Powder

Manufacturer country

Russia

Package quantity, pcs

6

Description

Powder for preparation of oral solution.

Packaging

5 g - heat-sealable sachets (3) - cardboard packs.

pharmachologic effect

The combined drug has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects.

Paracetamol has analgesic and antipyretic effects.

Ascorbic acid is involved in the regulation of redox processes, contributes to normal capillary permeability, blood clotting, tissue regeneration, plays a positive role in the development of the body's immune responses, replenishes vitamin C deficiency.

Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels, causing hemorrhagic processes in influenza and ARVI, has an anti-allergic effect (the mechanism is unclear).

Rimantadine has antiviral activity against influenza A. By blocking the M2 channels of influenza A virus, it disrupts its ability to enter cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication.

Induces the production of alpha and gamma interferons.

In influenza caused by the B virus, rimantadine has an antitoxic effect.

Rutoside is an angioprotective agent.

Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall.

It inhibits aggregation and increases the degree of erythrocyte deformation.

Loratadine - a blocker of histamine H1 receptors, prevents the development of tissue edema associated with the release of histamine.

Pharmacokinetics

Paracetamol

Absorption and distribution

Absorption is high.

According to the results of clinical studies, the following pharmacokinetic parameters of paracetamol were established: Cmax in blood plasma is achieved when the powder is applied after 0.7 ± 0.39 hours and is 4.79 ± 1.81 μg / ml.

Plasma protein binding - 15%.

Penetrates the BBB.

Metabolism and excretion

It is metabolized in the liver through three main pathways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine ​​and mercapturic acid. The main isoenzymes of cytochrome P450 for this metabolic pathway are the isoenzyme CYP2E1 (mainly), CYP1A2 and CYP3A4 (minor role). When glutathione is deficient, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates. In adults, glucuronidation predominates. Conjugated paracetamol metabolites (glucuronides,sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity.

It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

According to the results of clinical studies, T1 / 2 of paracetamol is 2.73 ± 0.76 hours.

Pharmacokinetics in special clinical situations

In elderly patients, drug clearance decreases and T1 / 2 increases.

Vitamin C

Absorption and distribution

Absorbed in the gastrointestinal tract (mainly in the jejunum).

Diseases of the gastrointestinal tract (peptic ulcer and duodenal ulcer, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbic acid in the intestine.

The concentration of ascorbic acid in plasma is normally approximately 10-20 μg / ml.

The time to reach Cmax in blood plasma after oral administration is 4 hours.

Plasma protein binding - 25%.

Easily penetrates into leukocytes, platelets, and then into all tissues

the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye

penetrates the placental ba

Dosage

etc.

x 5g

Structure

1 sachet contains active substances: paracetamol 360 mg, ascorbic acid 300 mg, calcium gluconate monohydrate 100 mg, rimantadine hydrochloride 50 mg, rutoside trihydrate (in terms of rutoside) 20 mg, loratadine 3 mg

Excipients: aspartame - 30 mg, hypromellose - 10 mg, colloidal silicon dioxide - 20 mg, lactose monohydrate - 4086 mg, food flavor (black currant) - 21 mg.

Storage conditions and periods

In a dry place, at a temperature not exceeding 25 degrees.

INN / Active ingredient

paracetamol, ascorbic acid, rimantadine, rutoside, loratadine, calcium gluconate

Specifications

Category

Pain and fever

Scope of the drug

General

Release form

Powder

Manufacturer country

Russia

Package quantity, pcs

6

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

PharmVILAR

The amount of the dosage form in the primary package

5 g

Primary packaging type

Sachet (sachet)

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

ARI and cold" symptoms remedy

The target audience

Adult

A type

Medicine

Expiration date in days

912

Package weight, g

twenty

Dosage (volume) of the substance in the preparation

:

paracetamol 360 mg, ascorbic acid 300 mg, calcium gluconate monohydrate 100 mg, rimantadine hydrochloride 50 mg, rutoside trihydrate (in terms of rutoside) 20 mg, loratadine 3 mg

Mode of application

:

Adults are prescribed 1 sachet by mouth 2-3 times / day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear. < br> If there is no improvement in the state of health, the drug should be stopped and consult a doctor. < br> The contents of 1 sachet should be dissolved in half a glass of boiled warm water and drunk immediately after dissolution.

Stir the solution before use.

Anatomical and therapeutic characteristics

:

R05X Preparations for the elimination of cold symptoms in combination with others

Dosage form

:

Powder for preparation of oral solution [black currant]

Information on technical characteristics, delivery set, country of manufacture "

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